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    LOC280930 ribonuclease, RNase A family, 1 (pancreatic) [ Bos taurus (domestic cattle) ]

    Gene ID: 280930, updated on 4-Oct-2024

    Summary

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    Gene symbol
    LOC280930
    Gene description
    ribonuclease, RNase A family, 1 (pancreatic)
    See related
    BGD:BT10837; Ensembl:ENSBTAG00000025663
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    SRN; RAC1; RNASE1
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    Genomic context

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    See LOC280930 in Genome Data Viewer
    Location:
    chromosome: 10
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 10 NC_037337.1 (26223844..26225388)

    Chromosome 10 - NC_037337.1Genomic Context describing neighboring genes Neighboring gene eosinophil cationic protein Neighboring gene ribonuclease pancreatic Neighboring gene brain ribonuclease Neighboring gene epididymal secretory protein E3-beta-like

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037337.1 Chromosome 10 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Heterogeneity of bovine seminal ribonuclease. Di Donato A, et al. Biochemistry, 1981 Dec 8. PMID 7317378
    2. Bovine seminal ribonuclease: structure at 1.9 A resolution. Mazzarella L, et al. Acta Crystallogr D Biol Crystallogr, 1993 Jul 1. PMID 15299514
    3. Role of the hinge peptide and the intersubunit interface in the swapping of N-termini in dimeric bovine seminal RNase. Ercole C, et al. Eur J Biochem, 2003 Dec. PMID 14622261
    4. Crystal structure of the dimeric unswapped form of bovine seminal ribonuclease. Berisio R, et al. FEBS Lett, 2003 Nov 6. PMID 14596923
    5. The unswapped chain of bovine seminal ribonuclease: Crystal structure of the free and liganded monomeric derivative. Sica F, et al. Proteins, 2003 Aug 1. PMID 12833549

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In the regions involved in 3D swapping, the study observed an accumulation of weaknesses in the monomer, which disappear in the dimer and especially in the swapped dimer.
      Title: Stability strengths and weaknesses in protein structures detected by statistical potentials: Application to bovine seminal ribonuclease.
    2. Data suggest that dimerization of seminal ribonuclease (SRN) facilitates three-dimensional domain swapping; both swapped and un-swapped dimers of SRN exhibit increased flexibility as compared to monomeric subunit SRN.
      Title: Mechanism of 3D domain swapping in bovine seminal ribonuclease.
    3. A report of the first clear experimental evidence on the formation of a C-terminal swapped dimer of the monomeric BS-RNase derivatives.
      Title: The multiple forms of bovine seminal ribonuclease: structure and stability of a C-terminal swapped dimer.
    4. Data indicate that BS-RNase oligomers are more enzymatically active than the native dimer.
      Title: Double domain swapping in bovine seminal RNase: formation of distinct N- and C-swapped tetramers and multimers with increasing biological activities.
    5. The domain swapping in BS-RNase must be influenced by the distinct features of the dimers, suggesting a prominent role for the interchain disulfide bridges.
      Title: NMR studies on structure and dynamics of the monomeric derivative of BS-RNase: new insights for 3D domain swapping.
    6. the replacement of of Arg80 by Ser significantly decreases the cytotoxic activity of BS-RNase and the stability of the NCD form with respect to the parent protein, but does not affect the ribonucleolytic activity or the dissociation mechanism
      Title: Structure-cytotoxicity relationships in bovine seminal ribonuclease: new insights from heat and chemical denaturation studies on variants.
    7. Data suggest that, in addition to Pro19 and Leu28, the presence of a glycine at the N-terminal end of the hinge peptide is also important to push the swapped form of RNase A dimer into the compact quaternary organization observed for NCD-BS.
      Title: Toward an antitumor form of bovine pancreatic ribonuclease: the crystal structure of three noncovalent dimeric mutants.
    8. Data show that all the proteins have a very poor cytotoxic activity, independently on the swapping propensity, that can even reach the same value of native BS-RNase.
      Title: Comparison of the structural and functional properties of RNase A and BS-RNase: a stepwise mutagenesis approach.
    9. The structural data enable existing kinetic data on the binding of these compounds to a variety of ribonucleases to be rationalized.
      Title: Influence of naturally-occurring 5'-pyrophosphate-linked substituents on the binding of adenylic inhibitors to ribonuclease a: an X-ray crystallographic study.
    10. Studies show the two isoforms of dimeric RNase, with interchange of the N-terminal helical segments, and without interchange.
      Title: It takes two to flirt with a dimeric RNase.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables RNA nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    seminal ribonuclease
    Names
    S-RNase
    ribonuclease A C1
    ribonuclease BS-1
    seminal RNase
    NP_861526.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_181810.1 → NP_861526.1  seminal ribonuclease precursor

      See identical proteins and their annotated locations for NP_861526.1

      Status: PROVISIONAL

      Source sequence(s)
      AJ000518
      UniProtKB/Swiss-Prot
      P00669
      UniProtKB/TrEMBL
      W0UV03
      Related
      ENSBTAP00000036091.3, ENSBTAT00000036229.4
      Conserved Domains (1) summary
      smart00092
      Location:27 → 150
      RNAse_Pc; Pancreatic ribonuclease

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037337.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      26223844..26225388
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P00669.2 GenPept UniProtKB/Swiss-Prot:P00669

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.