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    Tdpoz8 TD and POZ domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 229571, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tdpoz8provided by MGI
    Official Full Name
    TD and POZ domain containing 8provided by MGI
    Primary source
    MGI:MGI:3645677
    See related
    Ensembl:ENSMUSG00000096879 AllianceGenome:MGI:3645677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm4858; EG229571
    Summary
    Predicted to enable ubiquitin protein ligase binding activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process and regulation of proteolysis. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See Tdpoz8 in Genome Data Viewer
    Location:
    3 F1; 3 40.14 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (92976130..92982812)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (93068823..93075505)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene cysteine-rich C-terminal 1 Neighboring gene late cornified envelope 1M Neighboring gene predicted gene, 35785 Neighboring gene thymosin beta-10 pseudogene Neighboring gene cornulin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    2. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636
    3. RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer. Shibata K, et al. Genome Res, 2000 Nov. PMID 11076861, Free PMC Article
    4. Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes. Carninci P, et al. Genome Res, 2000 Oct. PMID 11042159, Free PMC Article
    5. Functional annotation of a full-length mouse cDNA collection. Kawai J, et al. Nature, 2001 Feb 8. PMID 11217851

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    TD and POZ domain containing-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034860.2 → NP_001030032.1  TD and POZ domain containing-like isoform 2

      See identical proteins and their annotated locations for NP_001030032.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice pattern and begins translation at a downstream start codon. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AK139723
      Consensus CDS
      CCDS38523.1
      UniProtKB/TrEMBL
      Q3UT66
      Related
      ENSMUSP00000141574.2, ENSMUST00000194595.2
      Conserved Domains (4) summary
      smart00225
      Location:63 → 161
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14734
      Location:161 → 222
      SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00651
      Location:54 → 158
      BTB; BTB/POZ domain
      cl02446
      Location:8 → 28
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

    2. NM_001177694.1 → NP_001171165.1  TD and POZ domain containing-like isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform. The structure of the 5' UTR has not been determined.
      Source sequence(s)
      AC135289, BC172161
      UniProtKB/TrEMBL
      B7ZWN5
      Related
      ENSMUSP00000141677.2, ENSMUST00000195847.2
      Conserved Domains (4) summary
      smart00225
      Location:189 → 287
      BTB; Broad-Complex, Tramtrack and Bric a brac
      cd14734
      Location:287 → 348
      SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins
      pfam00651
      Location:180 → 284
      BTB; BTB/POZ domain
      cl02446
      Location:16 → 154
      MATH; MATH (meprin and TRAF-C homology) domain; an independent folding unit with an eight-stranded beta-sandwich structure found in meprins, TRAFs and other proteins. Meprins comprise a class of extracellular metalloproteases which are anchored to the membrane ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      92976130..92982812
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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