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Coprox Coproporphyrinogen oxidase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44701, updated on 2-Nov-2024

Summary

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Official Symbol
Coproxprovided by FlyBase
Official Full Name
Coproporphyrinogen oxidaseprovided by FlyBase
Primary source
FLYBASE:FBgn0021944
Locus tag
Dmel_CG3433
See related
AllianceGenome:FB:FBgn0021944
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GM14838; CG3433; Dmel\CG3433; l(2)k10617; l(2)k11018
Summary
Predicted to enable coproporphyrinogen oxidase activity and protein homodimerization activity. Predicted to be involved in protoporphyrinogen IX biosynthetic process. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Is expressed in adult head; anterior midgut primordium; embryonic/larval midgut; organism; and posterior midgut primordium. Human ortholog(s) of this gene implicated in hereditary coproporphyria and liver disease. Orthologous to human CPOX (coproporphyrinogen oxidase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Coprox in Genome Data Viewer
Location:
27C7-27C7; 2-23 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (6964421..6965887)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (6964421..6965887)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ada2a-containing complex component 1 Neighboring gene 3-Hydroxymethyl-3-methylglutaryl-CoA lyase Neighboring gene septin interacting protein 2 Neighboring gene Small ubiquitin like modifier Neighboring gene small ribonucleoprotein particle U1 subunit 70K

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Spatial and temporal control of gene manipulation in Drosophila via drug-activated Cas9 nucleases. Huynh N, et al. Insect Biochem Mol Biol, 2020 May. PMID 32105778
  2. A Drosophila CRISPR/Cas9 Toolkit for Conditionally Manipulating Gene Expression in the Prothoracic Gland as a Test Case for Polytene Tissues. Huynh N, et al. G3 (Bethesda), 2018 Nov 6. PMID 30213867, Free PMC Article
  3. Identification and characterization of a heme exporter from the MRP family in Drosophila melanogaster. Wang Z, et al. BMC Biol, 2022 Jun 2. PMID 35655259, Free PMC Article
  4. Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS. Wang ZA, et al. Nat Commun, 2012 Apr 3. PMID 22473013, Free PMC Article
  5. Identification of transcriptional responsive genes to acetic acid, ethanol, and 2-phenylethanol exposure in Drosophila melanogaster. Seong KM, et al. Pestic Biochem Physiol, 2020 May. PMID 32359537

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables coproporphyrinogen oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables coproporphyrinogen oxidase activity IEA
Inferred from Electronic Annotation
more info
  
enables coproporphyrinogen oxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in heme biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in porphyrin-containing compound biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protoporphyrinogen IX biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
coproporphyrinogen oxidase
Names
CG3433-PA
CG3433-PB
Coprox-PA
Coprox-PB
corpoporphyrinogen III oxidase
NP_001285697.1
NP_524777.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    6964421..6965887
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298768.1 → NP_001285697.1  coproporphyrinogen oxidase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285697.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3D2
    UniProtKB/TrEMBL
    X2J9R2
    Conserved Domains (1) summary
    pfam01218
    Location:88 → 390
    Coprogen_oxidas; Coproporphyrinogen III oxidase

  2. NM_080038.4 → NP_524777.1  coproporphyrinogen oxidase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524777.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9V3D2
    UniProtKB/TrEMBL
    X2J9R2
    Related
    FBpp0078980
    Conserved Domains (1) summary
    pfam01218
    Location:88 → 390
    Coprogen_oxidas; Coproporphyrinogen III oxidase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V3D2.1 Q9V3D2
X2J9R2 X2J9R2

Gene LinkOut

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