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    Tbc1d16 TBC1 domain family, member 16 [ Mus musculus (house mouse) ]

    Gene ID: 207592, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Tbc1d16provided by MGI
    Official Full Name
    TBC1 domain family, member 16provided by MGI
    Primary source
    MGI:MGI:2652878
    See related
    Ensembl:ENSMUSG00000039976 AllianceGenome:MGI:2652878
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tcd1d16; B930087K01
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in regulation of receptor recycling. Predicted to be located in cytosol. Predicted to be active in early endosome. Orthologous to human TBC1D16 (TBC1 domain family member 16). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in CNS E18 (RPKM 26.7), whole brain E14.5 (RPKM 24.4) and 25 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tbc1d16 in Genome Data Viewer
    Location:
    11 E2; 11 83.34 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (119033869..119119354, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (119143043..119228503, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7107 Neighboring gene STARR-positive B cell enhancer ABC_E7108 Neighboring gene predicted gene 11754 Neighboring gene predicted gene, 35878 Neighboring gene STARR-positive B cell enhancer ABC_E7109 Neighboring gene predicted gene 11755 Neighboring gene STARR-positive B cell enhancer ABC_E1853 Neighboring gene STARR-positive B cell enhancer ABC_E7110 Neighboring gene microRNA 6934 Neighboring gene STARR-seq mESC enhancer starr_31313 Neighboring gene predicted gene 11753 Neighboring gene predicted gene, 36111 Neighboring gene STARR-seq mESC enhancer starr_31314 Neighboring gene coiled-coil domain containing 40 Neighboring gene predicted gene, 35932 Neighboring gene predicted gene, 46303

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables GTPase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of receptor recycling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in early endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in early endosome ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 16

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347625.1 → NP_001334554.1  TBC1 domain family member 16 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL662835, AL672140, BE996705
      Consensus CDS
      CCDS83940.1
      UniProtKB/TrEMBL
      Q6PFC0, Q8BXD8
      Related
      ENSMUSP00000147182.2, ENSMUST00000207655.2

    2. NM_172443.3 → NP_766031.2  TBC1 domain family member 16 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AK047555, AL662835, BQ831250, CJ111152
      Consensus CDS
      CCDS25711.1
      UniProtKB/TrEMBL
      A2ABG4, Q8BXD8
      Related
      ENSMUSP00000048516.4, ENSMUST00000036113.4
      Conserved Domains (1) summary
      smart00164
      Location:423 → 651
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      119033869..119119354 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245739.2 → XP_030101599.1  TBC1 domain family member 16 isoform X4

      UniProtKB/TrEMBL
      Q8BXD8
      Conserved Domains (1) summary
      smart00164
      Location:437 → 665
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    2. XM_006532694.3 → XP_006532757.1  TBC1 domain family member 16 isoform X2

      UniProtKB/TrEMBL
      Q8BXD8
      Conserved Domains (1) summary
      smart00164
      Location:438 → 666
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    3. XM_006532695.3 → XP_006532758.1  TBC1 domain family member 16 isoform X3

      UniProtKB/TrEMBL
      Q8BXD8
      Conserved Domains (1) summary
      smart00164
      Location:438 → 666
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    4. XM_006532693.3 → XP_006532756.1  TBC1 domain family member 16 isoform X1

      UniProtKB/TrEMBL
      Q8BXD8
      Conserved Domains (1) summary
      smart00164
      Location:439 → 667
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    5. XM_030245742.2 → XP_030101602.1  TBC1 domain family member 16 isoform X7

      UniProtKB/TrEMBL
      Q8BXD8
      Conserved Domains (1) summary
      smart00164
      Location:358 → 586
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    6. XM_030245743.2 → XP_030101603.1  TBC1 domain family member 16 isoform X8

      UniProtKB/TrEMBL
      Q8BXD8
      Conserved Domains (1) summary
      smart00164
      Location:357 → 585
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    7. XM_030245741.2 → XP_030101601.1  TBC1 domain family member 16 isoform X6

      UniProtKB/TrEMBL
      Q8BXD8
      Conserved Domains (1) summary
      smart00164
      Location:373 → 601
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    8. XM_030245740.2 → XP_030101600.1  TBC1 domain family member 16 isoform X5

      UniProtKB/TrEMBL
      Q8BXD8
      Conserved Domains (1) summary
      smart00164
      Location:374 → 602
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
    Nucleotide Protein Strain
    Heading Accession and Version

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