nhx-5 Sodium/hydrogen exchanger [Caenorhabditis elegans] - Gene

Summary

Official Symbol: nhx-5
Official Full Name: Sodium/hydrogen exchanger
Primary source: WormBase:WBGene00003733
Locus tag: CELE_F57C7.2
See related: AllianceGenome:WB:WBGene00003733
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in endosome membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane and recycling endosome. Is expressed in several structures, including HSN; excretory cell; ganglia; ventral nerve cord; and vulC. Human ortholog(s) of this gene implicated in Christianson syndrome; X-linked intellectual developmental disorder 108; and autistic disorder. Orthologous to several human genes including SLC9A9 (solute carrier family 9 member A9). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

NHX-5, an Endosomal Na+/H+ Exchanger, Is Associated with Metformin Action.
Title: NHX-5, an Endosomal Na+/H+ Exchanger, Is Associated with Metformin Action.

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables antiporter activity	IEA Inferred from Electronic Annotation more info
enables potassium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in monoatomic cation transport	IEA Inferred from Electronic Annotation more info
involved_in potassium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of intracellular pH	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of intracellular pH	IEA Inferred from Electronic Annotation more info
involved_in regulation of pH	IEA Inferred from Electronic Annotation more info
involved_in sodium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion transport	IEA Inferred from Electronic Annotation more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in endosome	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in recycling endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info

NP_001024720.1

NP_001359642.1

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The following sections contain reference sequences that belong to a specific genome build. Explain