DAL1 E3 Ubiquitin ligase family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: DAL1
Official Full Name: E3 Ubiquitin ligase family protein
Primary source: TAIR:AT1G63900
Locus tag: AT1G63900
See related: Araport:AT1G63900
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AT1G63890; DIAP1-like protein 1; SP1; SUPPRESSOR OF PPI1 locus 1; T12P18.8; T12P18_8
Summary: Encodes a RING-type ubiquitin E3 ligase of the chloroplast outer membrane that associates with TOC complexes and mediated ubiquitination of TOC components, promoting their degradation.
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Genomic context

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See DAL1 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 10

Sequence:: Chromosome: 1; NC_003070.9 (23716643..23719337)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MORF2-MORF9 heterodimer is a core member of editosomes in Arabidopsis chloroplasts. [MORF2]
Title: MORF2 tightly associates with MORF9 to regulate chloroplast RNA editing in Arabidopsis.
In this study, we identified the Arabidopsis RING-type E3 ubiquitin ligase SP1 as a peroxisome membrane protein that regulates peroxisome biogenesis.
Title: E3 ubiquitin ligase SP1 regulates peroxisome biogenesis in Arabidopsis.
SP1 protein (At1g63900) associated with TOC (translocon at the outer envelope of chloroplasts) complexes and mediated ubiquitination of TOC components, promoting degradation; mutant sp1 plants performed developmental transitions involving plastid proteome changes inefficiently, indicating requirement for reorganization of TOC machinery
Title: Chloroplast biogenesis is regulated by direct action of the ubiquitin-proteasome system.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_105064.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chloroplast organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of fatty acid beta-oxidation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of fatty acid beta-oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organelle organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein destabilization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein import into chloroplast stroma	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein import into peroxisome matrix	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in regulation of protein import into chloroplast stroma	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast envelope	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast outer membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in peroxisomal membrane	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: E3 Ubiquitin ligase family protein

NP_001319312.1

E3 Ubiquitin ligase family protein; FUNCTIONS IN: zinc ion binding; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), E3 Ubiquitin ligase (InterPro:IPR022170); BEST Arabidopsis thaliana protein match is: E3 Ubiquitin ligase family protein (TAIR:AT1G59560.1).

NP_176574.2

E3 Ubiquitin ligase family protein; FUNCTIONS IN: zinc ion binding; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), E3 Ubiquitin ligase (InterPro:IPR022170); BEST Arabidopsis thaliana protein match is: E3 Ubiquitin ligase family protein (TAIR:AT1G59560.1); Has 3444 Blast hits to 3338 proteins in 260 species: Archae - 0; Bacteria - 10; Metazoa - 1891; Fungi - 50; Plants - 799; Viruses - 222; Other Eukaryotes - 472 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

23716643..23719337

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001334139.1 → NP_001319312.1 E3 Ubiquitin ligase family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

F4I570
NM_105064.4 → NP_176574.2 E3 Ubiquitin ligase family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176574.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8L7N4, Q9CAK2, Q9CAK3

UniProtKB/TrEMBL

A0A178WJL1, A0A5S9WS89

Conserved Domains (2) summary

cd16515
Location:295 → 334

RING-HC_LRSAM1; RING finger, HC subclass, found in leucine-rich repeat and sterile alpha motif-containing protein 1 (LRSAM1) and similar proteins

pfam12483
Location:86 → 235

GIDE; E3 Ubiquitin ligase