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    GOX1 Aldolase-type TIM barrel family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820665, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GOX1
    Official Full Name
    Aldolase-type TIM barrel family protein
    Primary source
    TAIR:AT3G14420
    Locus tag
    AT3G14420
    See related
    Araport:AT3G14420
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    glycolate oxidase 1
    Summary
    Encodes a glycolate oxidase that modulates reactive oxygen species-mediated signal transduction during nonhost resistance.
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    Genomic context

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    See GOX1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    12
    Sequence:
    Chromosome: 3; NC_003074.8 (4821391..4824178)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Nucleotide/sugar transporter family protein Neighboring gene Aldolase-type TIM barrel family protein Neighboring gene GRIP/coiled-coil protein Neighboring gene nine-cis-epoxycarotenoid dioxygenase 3 Neighboring gene CTC-interacting domain 9

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Glycolate oxidase is an alternative source for H2O2 production during plant defense responses and functions independently from NADPH oxidase. Rojas C, et al. Plant Signal Behav, 2012 Jul. PMID 22751316, Free PMC Article
    2. Lack of GLYCOLATE OXIDASE1, but Not GLYCOLATE OXIDASE2, Attenuates the Photorespiratory Phenotype of CATALASE2-Deficient Arabidopsis. Kerchev P, et al. Plant Physiol, 2016 Jul. PMID 27225899, Free PMC Article
    3. Glycolate oxidase modulates reactive oxygen species-mediated signal transduction during nonhost resistance in Nicotiana benthamiana and Arabidopsis. Rojas CM, et al. Plant Cell, 2012 Jan. PMID 22286136, Free PMC Article
    4. Identification of BZR1-interacting proteins as potential components of the brassinosteroid signaling pathway in Arabidopsis through tandem affinity purification. Wang C, et al. Mol Cell Proteomics, 2013 Dec. PMID 24019147, Free PMC Article
    5. Proteome analysis of Arabidopsis leaf peroxisomes reveals novel targeting peptides, metabolic pathways, and defense mechanisms. Reumann S, et al. Plant Cell, 2007 Oct. PMID 17951448, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GOX1 role in photorespiration.
      Title: Lack of GLYCOLATE OXIDASE1, but Not GLYCOLATE OXIDASE2, Attenuates the Photorespiratory Phenotype of CATALASE2-Deficient Arabidopsis.
    2. GOX plays a role in nonhost resistance independent of NADPH oxidase. [GOX1]
      Title: Glycolate oxidase is an alternative source for H2O2 production during plant defense responses and functions independently from NADPH oxidase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_001035617.1
    NM_001084685.1
    NM_001084686.1
    NM_112302.4
    NM_180253.2
    NM_180254.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables (S)-2-hydroxy-acid oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables FMN binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within hydrogen peroxide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in nucleus HDA PubMed 
    located_in peroxisome HDA PubMed 
    located_in plasmodesma HDA PubMed 

    General protein information

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    Preferred Names
    Aldolase-type TIM barrel family protein
    NP_001030694.1
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: cytosolic ribosome, apoplast, chloroplast, peroxisome, membrane; EXPRESSED IN: cotyledon, fruit, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14415.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_001078154.1
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: apoplast, chloroplast, peroxisome, membrane; EXPRESSED IN: cotyledon, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14415.3); Has 11405 Blast hits to 11391 proteins in 1844 species: Archae - 148; Bacteria - 5372; Metazoa - 370; Fungi - 676; Plants - 262; Viruses - 0; Other Eukaryotes - 4577 (source: NCBI BLink).
    NP_001078155.1
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: apoplast, chloroplast, peroxisome, membrane; EXPRESSED IN: cotyledon, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14415.3); Has 11354 Blast hits to 11340 proteins in 1837 species: Archae - 148; Bacteria - 5331; Metazoa - 369; Fungi - 687; Plants - 262; Viruses - 0; Other Eukaryotes - 4557 (source: NCBI BLink).
    NP_188060.1
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: in 7 components; EXPRESSED IN: cotyledon, fruit, guard cell, juvenile leaf, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14415.3); Has 11706 Blast hits to 11682 proteins in 1857 species: Archae - 148; Bacteria - 5438; Metazoa - 369; Fungi - 697; Plants - 266; Viruses - 0; Other Eukaryotes - 4788 (source: NCBI BLink).
    NP_850584.1
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: in 6 components; EXPRESSED IN: cotyledon, fruit, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14415.3); Has 11706 Blast hits to 11682 proteins in 1857 species: Archae - 148; Bacteria - 5438; Metazoa - 369; Fungi - 697; Plants - 266; Viruses - 0; Other Eukaryotes - 4788 (source: NCBI BLink).
    NP_850585.2
    • Aldolase-type TIM barrel family protein; FUNCTIONS IN: glycolate oxidase activity; INVOLVED IN: oxidation reduction, metabolic process; LOCATED IN: in 6 components; EXPRESSED IN: cotyledon, fruit, guard cell, leaf; EXPRESSED DURING: seedling growth; CONTAINS InterPro DOMAIN/s: Aldolase-type TIM barrel (InterPro:IPR013785), FMN-dependent alpha-hydroxy acid dehydrogenase, active site (InterPro:IPR008259), FMN-dependent dehydrogenase (InterPro:IPR000262), Alpha-hydroxy acid dehydrogenase, FMN-dependent (InterPro:IPR012133); BEST Arabidopsis thaliana protein match is: Aldolase-type TIM barrel family protein (TAIR:AT3G14415.3); Has 11172 Blast hits to 11148 proteins in 1832 species: Archae - 138; Bacteria - 5055; Metazoa - 369; Fungi - 680; Plants - 260; Viruses - 0; Other Eukaryotes - 4670 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      4821391..4824178
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112302.4 → NP_188060.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_188060.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHI6, Q8VZA4, Q944K6, Q9LRR9
      UniProtKB/TrEMBL
      A0A178VGT8, A0A654FH32
      Conserved Domains (1) summary
      PLN02493
      Location:1 → 367
      PLN02493; probable peroxisomal (S)-2-hydroxy-acid oxidase

    2. NM_180254.2 → NP_850585.2  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850585.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VGT8, Q2V3V9
      Conserved Domains (2) summary
      PLN02493
      Location:1 → 367
      PLN02493; probable peroxisomal (S)-2-hydroxy-acid oxidase
      cd02809
      Location:8 → 351
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...

    3. NM_001084686.1 → NP_001078155.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078155.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VGT8, B3H4B8
      Conserved Domains (2) summary
      PLN02979
      Location:1 → 366
      PLN02979; glycolate oxidase
      cd02809
      Location:46 → 350
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...

    4. NM_001084685.1 → NP_001078154.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078154.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VGT8, A8MS37
      Conserved Domains (2) summary
      PLN02979
      Location:3 → 360
      PLN02979; glycolate oxidase
      cd02809
      Location:38 → 344
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...

    5. NM_001035617.1 → NP_001030694.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030694.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VGT8
      Conserved Domains (2) summary
      PLN02493
      Location:1 → 348
      PLN02493; probable peroxisomal (S)-2-hydroxy-acid oxidase
      cd02809
      Location:1 → 332
      alpha_hydroxyacid_oxid_FMN; Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate ...

    6. NM_180253.2 → NP_850584.1  Aldolase-type TIM barrel family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850584.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B9DHI6, Q8VZA4, Q944K6, Q9LRR9
      UniProtKB/TrEMBL
      A0A178VGT8, A0A654FH32
      Conserved Domains (1) summary
      PLN02493
      Location:1 → 367
      PLN02493; probable peroxisomal (S)-2-hydroxy-acid oxidase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LRR9.1

    Gene LinkOut

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