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    EMB1586 P-loop containing nucleoside triphosphate hydrolases superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837833, updated on 18-Sep-2024

    Summary

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    Official Symbol
    EMB1586
    Official Full Name
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    Primary source
    TAIR:AT1G12770
    Locus tag
    AT1G12770
    See related
    Araport:AT1G12770
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    embryo defective 1586; INCREASED SIZE EXCLUSION LIMIT 1; ISE1
    Summary
    Encodes a DEAD-box RNA helicase that localizes to mitochondria and is essential for regulating cell-to-cell transport via plasmodesmata.
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    Genomic context

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    See EMB1586 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (4351019..4353797)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene RHOMBOID-like protein 6 Neighboring gene Zinc finger, C3HC4 type (RING finger) family protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene UDP-D-glucose/UDP-D-galactose 4-epimerase 1 Neighboring gene DNA ligase-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Loss of the plant DEAD-box protein ISE1 leads to defective mitochondria and increased cell-to-cell transport via plasmodesmata. Stonebloom S, et al. Proc Natl Acad Sci U S A, 2009 Oct 6. PMID 19805190, Free PMC Article
    2. Identification of a developmental transition in plasmodesmatal function during embryogenesis in Arabidopsis thaliana. Kim I, et al. Development, 2002 Mar. PMID 11874921
    3. Discovering the RNA-Binding Proteome of Plant Leaves with an Improved RNA Interactome Capture Method. Bach-Pages M, et al. Biomolecules, 2020 Apr 24. PMID 32344669, Free PMC Article
    4. Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana. Theologis A, et al. Nature, 2000 Dec 14. PMID 11130712

    GeneRIFs: Gene References Into Functions

    General gene information

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    NM_101147.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA helicase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy NAS
    Non-traceable Author Statement
    more info
    		  
    acts_upstream_of_or_within plasmodesma organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within plasmodesmata-mediated intercellular transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    P-loop containing nucleoside triphosphate hydrolases superfamily protein
    NP_172737.2
    • embryo defective 1586 (EMB1586); FUNCTIONS IN: RNA helicase activity; INVOLVED IN: plasmodesma organization, plasmodesmata-mediated intercellular transport, embryo development ending in seed dormancy; LOCATED IN: mitochondrion; EXPRESSED IN: embryo, root, flower, shoot meristem; CONTAINS InterPro DOMAIN/s: RNA helicase, DEAD-box type, Q motif (InterPro:IPR014014), DNA/RNA helicase, DEAD/DEAH box type, N-terminal (InterPro:IPR011545), DEAD-like helicase, N-terminal (InterPro:IPR014001), DNA/RNA helicase, C-terminal (InterPro:IPR001650), Helicase, superfamily 1/2, ATP-binding domain (InterPro:IPR014021); BEST Arabidopsis thaliana protein match is: DEA(D/H)-box RNA helicase family protein (TAIR:AT5G60990.1); Has 38833 Blast hits to 38121 proteins in 2993 species: Archae - 753; Bacteria - 18819; Metazoa - 5837; Fungi - 4441; Plants - 2445; Viruses - 12; Other Eukaryotes - 6526 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      4351019..4353797
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001332052.1 → NP_001322468.1  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WLV2, Q8W4E1, Q9LN70, Q9LPX3
      UniProtKB/TrEMBL
      A0A5S9U4J8, A0A654E957
      Conserved Domains (3) summary
      smart00487
      Location:125 → 349
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:384 → 510
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:112 → 340
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    2. NM_101147.3 → NP_172737.2  P-loop containing nucleoside triphosphate hydrolases superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172737.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WLV2, Q8W4E1, Q9LN70, Q9LPX3
      UniProtKB/TrEMBL
      A0A5S9U4J8, A0A654E957
      Conserved Domains (3) summary
      smart00487
      Location:125 → 349
      DEXDc; DEAD-like helicases superfamily
      cd00079
      Location:384 → 510
      HELICc; Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may ...
      cl21455
      Location:112 → 340
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8W4E1.2

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