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    CAM8 calmodulin 8 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827114, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CAM8
    Official Full Name
    calmodulin 8
    Primary source
    TAIR:AT4G14640
    Locus tag
    AT4G14640
    See related
    Araport:AT4G14640
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtCML8; calmodulin 8; CALMODULIN 8; calmodulin-like 8; CML8; DL3360W; FCAALL.157
    Summary
    encodes a divergent member of calmodulin, which is an EF-hand family of Ca2+-binding proteins. This gene is expressed in leaves, flowers and siliques. The gene functionally complements yeast calmodulin 1 (CAM1). Also the protein does not form formed a complex with a basic amphiphilic helical peptide in the presence of Ca2+ in vitro. Authors suggest that this gene may represent a Ca2+-binding sensor protein that interacts with a more limited set of target proteins than do more conventional CaM isoforms.
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    Genomic context

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    See CAM8 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Sequence:
    Chromosome: 4; NC_003075.7 (8397693..8400226)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene hypothetical protein (DUF506) Neighboring gene germin-like protein 9 Neighboring gene uncharacterized protein Neighboring gene RNA polymerase Rpb7-like, N-terminal domain-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Same against Many: AtCML8, a Ca(2+) Sensor Acting as a Positive Regulator of Defense Responses against Several Plant Pathogens. Zhu X, et al. Int J Mol Sci, 2021 Sep 28. PMID 34638807, Free PMC Article
    2. AtCML8, a calmodulin-like protein, differentially activating CaM-dependent enzymes in Arabidopsis thaliana. Park HC, et al. Plant Cell Rep, 2010 Nov. PMID 20820784
    3. Respective contribution of CML8 and CML9, two arabidopsis calmodulin-like proteins, to plant stress responses. Zhu X, et al. Plant Signal Behav, 2017 May 4. PMID 28471263, Free PMC Article
    4. Characterization of three new members of the Arabidopsis thaliana calmodulin gene family: conserved and highly diverged members of the gene family functionally complement a yeast calmodulin null. Zielinski RE. Planta, 2002 Jan. PMID 11855649
    5. The Arabidopsis Receptor Kinase ZAR1 Is Required for Zygote Asymmetric Division and Its Daughter Cell Fate. Yu TY, et al. PLoS Genet, 2016 Mar. PMID 27014878, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Same against Many: AtCML8, a Ca(2+) Sensor Acting as a Positive Regulator of Defense Responses against Several Plant Pathogens.
      Title: The Same against Many: AtCML8, a Ca(2+) Sensor Acting as a Positive Regulator of Defense Responses against Several Plant Pathogens.
    2. Data showed that CML8, an Arabidopsis calcium sensor belonging to the calmodulin-like (CML) protein family, promotes plant immunity against the phytopathogenic bacteria Pseudomonas syringae pv tomato (strain DC3000). Interestingly, other CML proteins such as CML9 were also reported to contribute to plant immunity using the same pathosystem
      Title: Respective contribution of CML8 and CML9, two arabidopsis calmodulin-like proteins, to plant stress responses.
    3. AtCML8 acts as a calmodulin-like protein that resembles GmCaM4 with respect to antigenicity and CaM-dependent enzyme activation.
      Title: AtCML8, a calmodulin-like protein, differentially activating CaM-dependent enzymes in Arabidopsis thaliana.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001340951.1
    NM_117546.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within calcium-mediated signaling IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within detection of calcium ion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in response to bacterium IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    calmodulin 8
    NP_193200.1
    • calmodulin 8 (CAM8); FUNCTIONS IN: calcium ion binding; INVOLVED IN: detection of calcium ion, calcium-mediated signaling; LOCATED IN: cellular_component unknown; EXPRESSED IN: fruit, flower, root, leaf; CONTAINS InterPro DOMAIN/s: EF-Hand 1, calcium-binding site (InterPro:IPR018247), EF-HAND 2 (InterPro:IPR018249), EF-hand-like domain (InterPro:IPR011992), Calcium-binding EF-hand (InterPro:IPR002048), EF-hand (InterPro:IPR018248); BEST Arabidopsis thaliana protein match is: calmodulin-like 11 (TAIR:AT3G22930.1); Has 33710 Blast hits to 22755 proteins in 1732 species: Archae - 3; Bacteria - 155; Metazoa - 13848; Fungi - 7315; Plants - 7405; Viruses - 2; Other Eukaryotes - 4982 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      8397693..8400226
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001340950.1 → NP_001329798.1  calmodulin 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8U5

    2. NM_117546.4 → NP_193200.1  calmodulin 8 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193200.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O23320, Q29Q68
      UniProtKB/TrEMBL
      A0A178UTX1, A0A5S9XT20
      Conserved Domains (1) summary
      PTZ00184
      Location:6 → 148
      PTZ00184; calmodulin; Provisional

    3. NM_001340951.1 → NP_001329799.1  calmodulin 8 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8T8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O23320.1

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