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    3BETAHSD/D2 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817166, updated on 18-Sep-2024

    Summary

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    Official Symbol
    3BETAHSD/D2
    Official Full Name
    3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2
    Primary source
    TAIR:AT2G26260
    Locus tag
    AT2G26260
    See related
    Araport:AT2G26260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    3beta-hydroxysteroid- dehydrogenase/decarboxylase isoform 2; 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2; AT3BETAHSD/D; AT3BETAHSD/D2; T1D16.10; T1D16_10
    Summary
    Encodes an enzyme with 3beta-hydroxysteroid dehydrogenase/C4-decarboxylase activity <i>in vitro</i>. The activity of the enzyme was determined using microsomal extracts of yeast overexpressing the <i>Arabidopsis</i> gene. Cytosolic fractions failed to be associated to the activity, leading to the speculation that the enzyme is membrane-bound.
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    Genomic context

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    See 3BETAHSD/D2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    12
    Sequence:
    Chromosome: 2; NC_003071.7 (11178064..11183278)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uricase / urate oxidase / nodulin 35 Neighboring gene Transmembrane proteins 14C Neighboring gene 3-ketoacyl-CoA synthase 10 Neighboring gene BRCT domain DNA repair protein Neighboring gene CTC-interacting domain 7 Neighboring gene root-specific kinase 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RTN20 as well as RTN19 can be considered a specialised subclass of reticulons most likely not directly involved in ER tubulation and structure as shown for other reticulons, but in lipid regulation. [RTN19]
      Title: The odd one out: Arabidopsis reticulon 20 does not bend ER membranes but has a role in lipid regulation.
    2. Arabidopsis 3betaHSD/D genes thus appears to affect auxin transporter activity, possibly by altering sterol composition in the membranes.
      Title: Overexpression of 3β-hydroxysteroid dehydrogenases/C-4 decarboxylases causes growth defects possibly due to abnormal auxin transport in Arabidopsis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036345.1
    NM_128183.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 3-beta-hydroxy-delta5-steroid dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3beta-hydroxysteroid-4alpha-carboxylate 3-dehydrogenase (decarboxylating) [NAD(+)] activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in auxin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plant organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2
    NP_001031422.1
    • 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 (3BETAHSD/D2); FUNCTIONS IN: 3-beta-hydroxy-delta5-steroid dehydrogenase activity, sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; INVOLVED IN: steroid biosynthetic process, metabolic process; LOCATED IN: membrane; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Reticulon (InterPro:IPR003388), 3-beta hydroxysteroid dehydrogenase/isomerase (InterPro:IPR002225), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 (TAIR:AT1G47290.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_180194.2
    • 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 (3BETAHSD/D2); FUNCTIONS IN: 3-beta-hydroxy-delta5-steroid dehydrogenase activity, sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; INVOLVED IN: steroid biosynthetic process, metabolic process; LOCATED IN: membrane; EXPRESSED IN: 12 plant structures; EXPRESSED DURING: 4 anthesis, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: Reticulon (InterPro:IPR003388), NAD(P)-binding domain (InterPro:IPR016040), 3-beta hydroxysteroid dehydrogenase/isomerase (InterPro:IPR002225); BEST Arabidopsis thaliana protein match is: 3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 1 (TAIR:AT1G47290.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      11178064..11183278
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128183.4 → NP_180194.2  3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180194.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64845, Q67ZE1
      UniProtKB/TrEMBL
      A0A178VT10
      Conserved Domains (3) summary
      cd09813
      Location:11 → 358
      3b-HSD-NSDHL-like_SDR_e; human NSDHL (NAD(P)H steroid dehydrogenase-like protein)-like, extended (e) SDRs
      pfam01073
      Location:13 → 288
      3Beta_HSD; 3-beta hydroxysteroid dehydrogenase/isomerase family
      pfam02453
      Location:384 → 539
      Reticulon; Reticulon

    2. NM_001036345.1 → NP_001031422.1  3beta-hydroxysteroid-dehydrogenase/decarboxylase isoform 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031422.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VT10
      Conserved Domains (2) summary
      pfam02453
      Location:293 → 448
      Reticulon; Reticulon
      cl21454
      Location:1 → 267
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q67ZE1.2

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