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    SCD1 stomatal cytokinesis defective / SCD1 protein (SCD1) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841327, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SCD1
    Official Full Name
    stomatal cytokinesis defective / SCD1 protein (SCD1)
    Primary source
    TAIR:AT1G49040
    Locus tag
    AT1G49040
    See related
    Araport:AT1G49040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F27J15.17; F27J15_17; STOMATAL CYTOKINESIS-DEFECTIVE 1
    Summary
    Encodes soluble protein containing N-terminal DENN domain and eight C-terminal WD-40 repeats. Involved in cytokinesis of guard mother cells and leaf epidermal cells. The overall growth and development of mutant plants is severely affected, they are smaller than wt, with defects in seedling development, leaf expansion and flower morphology which renders the mutant conditionally sterile.
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    Genomic context

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    See SCD1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    31
    Sequence:
    Chromosome: 1; NC_003070.9 (18139174..18149019, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene tRNA-Asp Neighboring gene PLAC8 family protein Neighboring gene uncharacterized protein Neighboring gene Eukaryotic aspartyl protease family protein Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SCD1 is required for cytokinesis and polarized cell expansion in Arabidopsis thaliana [corrected]. Falbel TG, et al. Development, 2003 Sep. PMID 12874123
    2. Mediation of clathrin-dependent trafficking during cytokinesis and cell expansion by Arabidopsis stomatal cytokinesis defective proteins. McMichael CM, et al. Plant Cell, 2013 Oct. PMID 24179130, Free PMC Article
    3. Novel functions of Stomatal Cytokinesis-Defective 1 (SCD1) in innate immune responses against bacteria. Korasick DA, et al. J Biol Chem, 2010 Jul 23. PMID 20472560, Free PMC Article
    4. Characterization of Arabidopsis and rice DWD proteins and their roles as substrate receptors for CUL4-RING E3 ubiquitin ligases. Lee JH, et al. Plant Cell, 2008 Jan. PMID 18223036, Free PMC Article
    5. Arabidopsis DDB1-CUL4 ASSOCIATED FACTOR1 forms a nuclear E3 ubiquitin ligase with DDB1 and CUL4 that is involved in multiple plant developmental processes. Zhang Y, et al. Plant Cell, 2008 Jun. PMID 18552200, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SCD1 and SCD2 function in clathrin-mediated membrane trafficking essential to both cytokinesis and cell expansion.
      Title: Mediation of clathrin-dependent trafficking during cytokinesis and cell expansion by Arabidopsis stomatal cytokinesis defective proteins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001198248.1
    NM_103797.4
    NM_180628.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cytokinesis by cell plate formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    NOT involved_in guard cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within guard mother cell cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within multidimensional cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of innate immune response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Cul4-RING E3 ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in clathrin-coated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    stomatal cytokinesis defective / SCD1 protein (SCD1)
    NP_001185177.1
    • STOMATAL CYTOKINESIS-DEFECTIVE 1 (SCD1); INVOLVED IN: multidimensional cell growth, guard mother cell cytokinesis, cytokinesis by cell plate formation; LOCATED IN: CUL4 RING ubiquitin ligase complex; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), dDENN (InterPro:IPR005112), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), uDENN (InterPro:IPR005113), WD40 repeat-like-containing domain (InterPro:IPR011046), DENN (InterPro:IPR001194), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: pleiotropic regulatory locus 1 (TAIR:AT4G15900.1).
    NP_175333.3
    • STOMATAL CYTOKINESIS-DEFECTIVE 1 (SCD1); CONTAINS InterPro DOMAIN/s: uDENN (InterPro:IPR005113), DENN (InterPro:IPR001194), dDENN (InterPro:IPR005112); BEST Arabidopsis thaliana protein match is: DENN (AEX-3) domain-containing protein (TAIR:AT5G35560.1); Has 1652 Blast hits to 1649 proteins in 159 species: Archae - 0; Bacteria - 0; Metazoa - 1121; Fungi - 143; Plants - 128; Viruses - 0; Other Eukaryotes - 260 (source: NCBI BLink).
    NP_850959.1
    • STOMATAL CYTOKINESIS-DEFECTIVE 1 (SCD1); CONTAINS InterPro DOMAIN/s: WD40 repeat 2 (InterPro:IPR019782), dDENN (InterPro:IPR005112), WD40 repeat, conserved site (InterPro:IPR019775), WD40 repeat (InterPro:IPR001680), G-protein beta WD-40 repeat, region (InterPro:IPR020472), uDENN (InterPro:IPR005113), WD40 repeat-like-containing domain (InterPro:IPR011046), DENN (InterPro:IPR001194), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: Transducin/WD40 repeat-like superfamily protein (TAIR:AT5G23430.2); Has 71080 Blast hits to 32273 proteins in 828 species: Archae - 56; Bacteria - 8068; Metazoa - 28161; Fungi - 15613; Plants - 9829; Viruses - 0; Other Eukaryotes - 9353 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      18139174..18149019 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333364.1 → NP_001320175.1  stomatal cytokinesis defective / SCD1 protein (SCD1) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I062

    2. NM_180628.4 → NP_850959.1  stomatal cytokinesis defective / SCD1 protein (SCD1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850959.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8RXA7, Q9M9A6, Q9M9A7
      UniProtKB/TrEMBL
      A0A178WQS8, A0A5S9WK86
      Conserved Domains (5) summary
      smart00801
      Location:366 → 430
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:123 → 306
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:1 → 103
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      cd00200
      Location:835 → 1131
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:904 → 937
      7WD40; WD40 repeat [structural motif]

    3. NM_001198248.1 → NP_001185177.1  stomatal cytokinesis defective / SCD1 protein (SCD1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001185177.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9WK86, F4I061
      Conserved Domains (6) summary
      smart00801
      Location:366 → 430
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:123 → 306
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:1 → 103
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      COG2319
      Location:834 → 1030
      WD40; WD40 repeat [General function prediction only]
      cd00200
      Location:835 → 1026
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:902 → 936
      7WD40; WD40 repeat [structural motif]

    4. NM_103797.4 → NP_175333.3  stomatal cytokinesis defective / SCD1 protein (SCD1) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_175333.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4I062
      Conserved Domains (3) summary
      smart00801
      Location:366 → 430
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00799
      Location:123 → 306
      DENN; Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN
      smart00800
      Location:1 → 103
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8RXA7.1

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