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    PIF7 phytochrome-interacting factor7 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836248, updated on 23-Sep-2024

    Summary

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    Official Symbol
    PIF7
    Official Full Name
    phytochrome-interacting factor7
    Primary source
    TAIR:AT5G61270
    Locus tag
    AT5G61270
    See related
    Araport:AT5G61270
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MFB13.4; MFB13_4; phytochrome-interacting factor7
    Summary
    Basic helix-loop-helix (bHLH) phytochrome interacting factor. Interacts specifically with the far-red light#Aeiabsorbing Pfr form of phyB through a conserved domain called the active phyB binding motif. Upon light exposure, PIF7 rapidly migrates to intranuclear speckles, where it colocalizes with phyB. Role as negative regulator of phyB-mediated seedling deetiolation.
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    Genomic context

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    See PIF7 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    6
    Sequence:
    Chromosome: 5; NC_003076.8 (24638491..24640765, complement)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene Ankyrin repeat family protein Neighboring gene Leucine-rich repeat (LRR) family protein Neighboring gene glucuronidase 1 Neighboring gene Plant calmodulin-binding protein-like protein Neighboring gene Remorin family protein Neighboring gene Flavin-binding monooxygenase family protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PIF7-mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis. Yang C, et al. EMBO J, 2023 Apr 17. PMID 36912149, Free PMC Article
    2. Phytochrome-imposed inhibition of PIF7 activity shapes photoperiodic growth in Arabidopsis together with PIF1, 3, 4 and 5. Leivar P, et al. Physiol Plant, 2020 Jul. PMID 32412656
    3. An RNA thermoswitch regulates daytime growth in Arabidopsis. Chung BYW, et al. Nat Plants, 2020 May. PMID 32284544, Free PMC Article
    4. Linking photoreceptor excitation to changes in plant architecture. Li L, et al. Genes Dev, 2012 Apr 15. PMID 22508725, Free PMC Article
    5. PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism. Hussain E, et al. Proc Natl Acad Sci U S A, 2022 Feb 1. PMID 35086930, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PHYTOCHROME-INTERACTING FACTOR 7 and RELATIVE OF EARLY FLOWERING 6 act in shade avoidance memory in Arabidopsis.
      Title: PHYTOCHROME-INTERACTING FACTOR 7 and RELATIVE OF EARLY FLOWERING 6 act in shade avoidance memory in Arabidopsis.
    2. PIF7-mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis.
      Title: PIF7-mediated epigenetic reprogramming promotes the transcriptional response to shade in Arabidopsis.
    3. PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism.
      Title: PIF7 controls leaf cell proliferation through an AN3 substitution repression mechanism.
    4. Ubiquitin-specific proteases UBP12 and UBP13 promote shade avoidance response by enhancing PIF7 stability.
      Title: Ubiquitin-specific proteases UBP12 and UBP13 promote shade avoidance response by enhancing PIF7 stability.
    5. PHYTOCHROME INTERACTING FACTOR 7 is important for early responses to elevated temperature in Arabidopsis seedlings.
      Title: PHYTOCHROME INTERACTING FACTOR 7 is important for early responses to elevated temperature in Arabidopsis seedlings.
    6. An RNA thermoswitch regulates daytime growth in Arabidopsis.
      Title: An RNA thermoswitch regulates daytime growth in Arabidopsis.
    7. Phytochrome-imposed inhibition of PIF7 activity shapes photoperiodic growth in Arabidopsis together with PIF1, 3, 4 and 5.
      Title: Phytochrome-imposed inhibition of PIF7 activity shapes photoperiodic growth in Arabidopsis together with PIF1, 3, 4 and 5.
    8. A PIF7-CONSTANS-Centered Molecular Regulatory Network Underlying Shade-Accelerated Flowering
      Title: A PIF7-CONSTANS-Centered Molecular Regulatory Network Underlying Shade-Accelerated Flowering.
    9. Shade-induced nuclear localization of PIF7 is regulated by phosphorylation and 14-3-3 proteins in Arabidopsis.
      Title: Shade-induced nuclear localization of PIF7 is regulated by phosphorylation and 14-3-3 proteins in Arabidopsis.
    10. PIF7 regulates the expression of shade-responsive genes.PIF7 recruits MRG1 and MRG2 that binds H3K4me3/H3K36me3 and brings histone-acetylases to induce histone acetylations to promote expression of shade responsive genes.
      Title: Linking PHYTOCHROME-INTERACTING FACTOR to Histone Modification in Plant Shade Avoidance.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001037040.3
    NM_001345463.1
    NM_125520.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within de-etiolation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    phytochrome-interacting factor7
    NP_001032117.1
    • phytochrome-interacting factor7 (PIF7); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G00050.1); Has 12429 Blast hits to 8555 proteins in 433 species: Archae - 0; Bacteria - 195; Metazoa - 4169; Fungi - 1073; Plants - 3281; Viruses - 14; Other Eukaryotes - 3697 (source: NCBI BLink).
    NP_200935.2
    • phytochrome-interacting factor7 (PIF7); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: basic helix-loop-helix (bHLH) DNA-binding superfamily protein (TAIR:AT4G00050.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      24638491..24640765 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_125520.5 → NP_200935.2  phytochrome-interacting factor7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_200935.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q570R7, Q7XJ93, Q9FLK6
      UniProtKB/TrEMBL
      A0A654GD06, C0SVV2
      Conserved Domains (1) summary
      smart00353
      Location:172 → 220
      HLH; helix loop helix domain

    2. NM_001037040.3 → NP_001032117.1  phytochrome-interacting factor7 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001032117.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UKL9
      Conserved Domains (1) summary
      cl00081
      Location:78 → 141
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

    3. NM_001345463.1 → NP_001331793.1  phytochrome-interacting factor7 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UKL9
      Conserved Domains (1) summary
      cl00081
      Location:78 → 141
      bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q570R7.2

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