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    ATFP8 Ras-related small GTP-binding family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 820345, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ATFP8
    Official Full Name
    Ras-related small GTP-binding family protein
    Primary source
    TAIR:AT3G11730
    Locus tag
    AT3G11730
    See related
    Araport:AT3G11730
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA RAB GTPASE HOMOLOG D1; ATRABD1; RAB GTPASE HOMOLOG D1; RABD1
    Summary
    Encodes a member of the Rab GTPase family of proteins. This protein interacts with the tail region of a myosin XI protein (AT5G43900) in a GTP-dependent manner. It has also been identified as an isoprenylated protein.
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    Genomic context

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    See ATFP8 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    8
    Sequence:
    Chromosome: 3; NC_003074.8 (3709131..3711617, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene lysyl-tRNA synthetase 1 Neighboring gene Polyketide cyclase/dehydrase and lipid transport superfamily protein Neighboring gene LURP-one-like protein (DUF567) Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An isoform of Arabidopsis myosin XI interacts with small GTPases in its C-terminal tail region. Hashimoto K, et al. J Exp Bot, 2008. PMID 18703495, Free PMC Article
    2. Genetic evidence that the higher plant Rab-D1 and Rab-D2 GTPases exhibit distinct but overlapping interactions in the early secretory pathway. Pinheiro H, et al. J Cell Sci, 2009 Oct 15. PMID 19789181, Free PMC Article
    3. A high content in lipid-modified peripheral proteins and integral receptor kinases features in the arabidopsis plasma membrane proteome. Marmagne A, et al. Mol Cell Proteomics, 2007 Nov. PMID 17644812
    4. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    5. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Rab-D1 and Rab-D2 subclasses have overlapping functions.
      Title: Genetic evidence that the higher plant Rab-D1 and Rab-D2 GTPases exhibit distinct but overlapping interactions in the early secretory pathway.
    2. AtRabD1 and AtRabC2a interact with the C-terminal tail region of MYA2.
      Title: An isoform of Arabidopsis myosin XI interacts with small GTPases in its C-terminal tail region.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_112005.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables GTP-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables myosin XI tail binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane HDA PubMed 
    located_in trans-Golgi network membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Ras-related small GTP-binding family protein
    NP_187779.1
    • ATFP8; FUNCTIONS IN: GTP binding, myosin XI tail binding, GTP-dependent protein binding; INVOLVED IN: protein transport, small GTPase mediated signal transduction; LOCATED IN: plasma membrane; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ras GTPase (InterPro:IPR001806), Small GTP-binding protein (InterPro:IPR005225), Small GTPase (InterPro:IPR020851), Ras (InterPro:IPR013753), Ras small GTPase, Rab type (InterPro:IPR003579); BEST Arabidopsis thaliana protein match is: RAB GTPase homolog 1A (TAIR:AT5G47200.1); Has 29795 Blast hits to 29734 proteins in 779 species: Archae - 25; Bacteria - 142; Metazoa - 15645; Fungi - 4180; Plants - 3599; Viruses - 20; Other Eukaryotes - 6184 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      3709131..3711617 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_112005.4 → NP_187779.1  Ras-related small GTP-binding family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_187779.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9ZRE2
      UniProtKB/TrEMBL
      A0A178VII7, A0A5S9XBG2
      Conserved Domains (1) summary
      cd01869
      Location:7 → 172
      Rab1_Ypt1; Rab GTPase family 1 includes the yeast homolog Ypt1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9ZRE2.1

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