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    BLH4 BEL1-like homeodomain 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816908, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BLH4
    Official Full Name
    BEL1-like homeodomain 4
    Primary source
    TAIR:AT2G23760
    Locus tag
    AT2G23760
    See related
    Araport:AT2G23760
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BEL1-like homeodomain 4; F27L4.6; F27L4_6; SAW2; SAWTOOTH 2
    Summary
    Encodes a member of the BEL family of homeodomain proteins. Plants doubly mutant for saw1/saw2 (blh2/blh4) have serrated leaves. BP is expressed in the serrated leaves, therefore saw2 and saw1 may act redundantly to repress BP in leaves.
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    Genomic context

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    See BLH4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    5
    Sequence:
    Chromosome: 2; NC_003071.7 (10107707..10113327, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene histone-lysine N-methyltransferase SUVR5 Neighboring gene transmembrane family 220 helix protein Neighboring gene protein kinase family protein / peptidoglycan-binding LysM domain-containing protein Neighboring gene RING/U-box superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SAW homeodomain transcription factors regulate initiation of leaf margin serrations. Jeon HW, et al. J Exp Bot, 2021 Feb 27. PMID 33247922
    2. Transcription Factors BLH2 and BLH4 Regulate Demethylesterification of Homogalacturonan in Seed Mucilage. Xu Y, et al. Plant Physiol, 2020 May. PMID 32111623, Free PMC Article
    3. The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act redundantly to regulate KNOX expression spatially in leaf margins. Kumar R, et al. Plant Cell, 2007 Sep. PMID 17873098, Free PMC Article
    4. A central role of Arabidopsis thaliana ovate family proteins in networking and subcellular localization of 3-aa loop extension homeodomain proteins. Hackbusch J, et al. Proc Natl Acad Sci U S A, 2005 Mar 29. PMID 15781858, Free PMC Article
    5. Toward an interaction map of the two-component signaling pathway of Arabidopsis thaliana. Dortay H, et al. J Proteome Res, 2008 Sep. PMID 18642946

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SAW homeodomain transcription factors regulate initiation of leaf margin serrations.
      Title: SAW homeodomain transcription factors regulate initiation of leaf margin serrations.
    2. These data suggest that BLH2/SAW1 and BLH4/SAW2 establish leaf shape by repressing growth in specific subdomains of the leaf at least in part by repressing expression of one or more of the KNOX genes. [SAW2]
      Title: The Arabidopsis BEL1-LIKE HOMEODOMAIN proteins SAW1 and SAW2 act redundantly to regulate KNOX expression spatially in leaf margins.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001036327.2
    NM_001335865.1
    NM_127939.3
    NM_179713.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within leaf morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within mucilage pectin metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    BEL1-like homeodomain 4
    NP_001031404.1
    • BEL1-like homeodomain 4 (BLH4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: leaf morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Homeobox KN domain (InterPro:IPR008422), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 2 (TAIR:AT4G36870.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_179956.1
    • BEL1-like homeodomain 4 (BLH4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: N-terminal protein myristoylation, leaf morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Homeobox KN domain (InterPro:IPR008422), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 2 (TAIR:AT4G36870.2); Has 5634 Blast hits to 5559 proteins in 359 species: Archae - 0; Bacteria - 6; Metazoa - 2382; Fungi - 373; Plants - 2492; Viruses - 0; Other Eukaryotes - 381 (source: NCBI BLink).
    NP_850044.1
    • BEL1-like homeodomain 4 (BLH4); FUNCTIONS IN: DNA binding, sequence-specific DNA binding transcription factor activity; INVOLVED IN: leaf morphogenesis; LOCATED IN: nucleus; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Homeobox KN domain (InterPro:IPR008422), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 2 (TAIR:AT4G36870.2); Has 5635 Blast hits to 5560 proteins in 359 species: Archae - 0; Bacteria - 6; Metazoa - 2382; Fungi - 374; Plants - 2492; Viruses - 0; Other Eukaryotes - 381 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10107707..10113327 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_179713.3 → NP_850044.1  BEL1-like homeodomain 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850044.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64826, Q56WI2, Q94KL5
      UniProtKB/TrEMBL
      A0A5S9X0S1, A0A654EVG8
      Conserved Domains (2) summary
      smart00574
      Location:233 → 370
      POX; domain associated with HOX domains
      pfam05920
      Location:442 → 481
      Homeobox_KN; Homeobox KN domain

    2. NM_001036327.2 → NP_001031404.1  BEL1-like homeodomain 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031404.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64826, Q56WI2, Q94KL5
      UniProtKB/TrEMBL
      A0A5S9X0S1, A0A654EVG8
      Conserved Domains (2) summary
      smart00574
      Location:233 → 370
      POX; domain associated with HOX domains
      pfam05920
      Location:442 → 481
      Homeobox_KN; Homeobox KN domain

    3. NM_127939.3 → NP_179956.1  BEL1-like homeodomain 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179956.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O64826, Q56WI2, Q94KL5
      UniProtKB/TrEMBL
      A0A5S9X0S1, A0A654EVG8
      Conserved Domains (2) summary
      smart00574
      Location:233 → 370
      POX; domain associated with HOX domains
      pfam05920
      Location:442 → 481
      Homeobox_KN; Homeobox KN domain

    4. NM_001335865.1 → NP_001324137.1  BEL1-like homeodomain 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZ70, A0A654EVG8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94KL5.2

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