STM KNOX/ELK homeobox transcription factor [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: STM
Official Full Name: KNOX/ELK homeobox transcription factor
Primary source: TAIR:AT1G62360
Locus tag: AT1G62360
See related: Araport:AT1G62360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: BUM; BUM1; BUMBERSHOOT; BUMBERSHOOT 1; F24O1.38; F24O1_38; HOMEOBOX PROTEIN SHOOTMERISTEMLESS; SHL; SHOOT MERISTEMLESS; SHOOTLESS; WALDMEISTER; WALDMEISTER 1; WAM; WAM1
Summary: Class I knotted-like homeodomain protein that is required for shoot apical meristem (SAM) formation during embryogenesis and for SAM function throughout the lifetime of the plant. Functions by preventing incorporation of cells in the meristem center into differentiating organ primordia.
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Genomic context

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See STM in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 4

Sequence:: Chromosome: 1; NC_003070.9 (23058582..23062063, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in Arabidopsis.
Title: Sugar signaling modulates SHOOT MERISTEMLESS expression and meristem function in Arabidopsis.
Condensation of STM is critical for shoot meristem maintenance and salt tolerance in Arabidopsis.
Title: Condensation of STM is critical for shoot meristem maintenance and salt tolerance in Arabidopsis.
A sustained CYCLINB1;1 and STM expression in the neoplastic tissues induced by Rhodococcus fascians on Arabidopsis underlies the persistence of the leafy gall structure.
Title: A sustained CYCLINB1;1 and STM expression in the neoplastic tissues induced by Rhodococcus fascians on Arabidopsis underlies the persistence of the leafy gall structure.
FTIP3/4 prevent intracellular trafficking of a key regulator, SHOOTMERISTEMLESS (STM), to the plasma membrane in cells in the peripheral shoot meristem region.
Title: FTIP-Dependent STM Trafficking Regulates Shoot Meristem Development in Arabidopsis.
The contribution of gene repression to reproductive primordium initiation is poorly understood. Here we show that downregulation of the STM pluripotency gene promotes initiation of flowers and uncover the mechanism for STM silencing.
Title: Auxin Response Factors promote organogenesis by chromatin-mediated repression of the pluripotency gene SHOOTMERISTEMLESS.
STM activates expression of the CUC1-targeting microRNA miR164c combined with mathematical modelling provides a potential solution for this apparent contradiction, demonstrating that these proposed regulatory interactions coupled with STM mobility could be sufficient to provide a mechanism for CUC1 localisation at the meristem-organ boundary.
Title: Coordination of meristem and boundary functions by transcription factors in the SHOOT MERISTEMLESS regulatory network.
These observations suggest that the MYB96-STM module contributes to enhancing plant tolerance to drought stress.
Title: Increased STM expression is associated with drought tolerance in Arabidopsis.
The authors test and demonstrate that STM expression is induced after micromechanical perturbations.
Title: Mechanical stress contributes to the expression of the STM homeobox gene in Arabidopsis shoot meristems.
The ELK domain has a role in the posttranslational regulation of STM by affecting the nuclear localization of STM.
Title: Transcriptional, posttranscriptional, and posttranslational regulation of SHOOT MERISTEMLESS gene expression in Arabidopsis determines gene function in the shoot apex.
In the cambium, KNAT1 and STM, contrary to their function in the shoot apical meristem, promote cell differentiation through repression of BOP genes.
Title: Class I KNOX transcription factors promote differentiation of cambial derivatives into xylem fibers in the Arabidopsis hypocotyl.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_104916.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within carpel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokinin biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within floral meristem determinacy	IGI Inferred from Genetic Interaction more info	PubMed
involved_in plasmodesmata-mediated intercellular transport	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of meristem structural organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stem cell population maintenance	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with cytoplasm	IPI Inferred from Physical Interaction more info	PubMed
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	IDA Inferred from Direct Assay more info	PubMed
located_in plasmodesma	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: KNOX/ELK homeobox transcription factor

NP_176426.1

SHOOT MERISTEMLESS (STM); CONTAINS InterPro DOMAIN/s: KNOX2 (InterPro:IPR005541), ELK (InterPro:IPR005539), Homeobox (InterPro:IPR001356), Homeobox, conserved site (InterPro:IPR017970), KNOX1 (InterPro:IPR005540), Homeodomain-like (InterPro:IPR009057), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: KNOTTED-like from Arabidopsis thaliana (TAIR:AT4G08150.1); Has 6066 Blast hits to 6064 proteins in 384 species: Archae - 0; Bacteria - 0; Metazoa - 1706; Fungi - 298; Plants - 3900; Viruses - 0; Other Eukaryotes - 162 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

23058582..23062063 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104916.4 → NP_176426.1 KNOX/ELK homeobox transcription factor [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176426.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q38874, Q8RXJ1, Q9MAV3

UniProtKB/TrEMBL

A0A178WBW0, A0A5S9WNN4

Conserved Domains (4) summary

pfam03789
Location:262 → 283

ELK; ELK domain

pfam03790
Location:121 → 156

KNOX1; KNOX1 domain

pfam03791
Location:173 → 216

KNOX2; KNOX2 domain

pfam05920
Location:302 → 341

Homeobox_KN; Homeobox KN domain