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    LASVsSgp1 nucleoprotein [ Mammarenavirus lassaense ]

    Gene ID: 956584, updated on 18-Aug-2023

    Summary

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    Gene symbol
    LASVsSgp1
    Gene description
    nucleoprotein
    Locus tag
    LASVsSgp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mammarenavirus lassaense (strain: Josiah)
    Lineage
    Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina; Ellioviricetes; Bunyavirales; Arenaviridae; Mammarenavirus
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    Genomic context

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    Location:
    segment: S
    Sequence:
    NC_004296.1 (101..1810)

    NC_004296.1Genomic Context describing neighboring genes Neighboring gene glycoprotein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004296.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Exonuclease domain of the Lassa virus nucleoprotein is critical to avoid RIG-I signaling and to inhibit the innate immune response. Reynard S, et al. J Virol, 2014 Dec. PMID 25253344, Free PMC Article
    2. The exonuclease domain of Lassa virus nucleoprotein is involved in antigen-presenting-cell-mediated NK cell responses. Russier M, et al. J Virol, 2014 Dec. PMID 25253342, Free PMC Article
    3. The role of oligomerization for the biological functions of the arenavirus nucleoprotein. Lennartz F, et al. Arch Virol, 2013 Sep. PMID 23553456
    4. Studies on the binding modes of Lassa nucleoprotein complexed with m7GpppG and dTTP by molecular dynamic simulations and free energy calculations. Li L, et al. J Biomol Struct Dyn, 2013 Mar. PMID 22871039
    5. Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy. Brunotte L, et al. J Biol Chem, 2011 Nov 4. PMID 21917929, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. These results highlight the key role of nucleoprotein exonuclease domain function in the immune evasion that occurs during Lassa virus infection.
      Title: Exonuclease domain of the Lassa virus nucleoprotein is critical to avoid RIG-I signaling and to inhibit the innate immune response.
    2. Importantly, authors demonstrate for the first time that Lassa virus nucleoprotein is involved in the inhibition of antigen-presenting cell-mediated NK cell responses.
      Title: The exonuclease domain of Lassa virus nucleoprotein is involved in antigen-presenting-cell-mediated NK cell responses.
    3. NP trimerization is essential for transcription and/or replication of the viral genome.
      Title: The role of oligomerization for the biological functions of the arenavirus nucleoprotein.
    4. molecular dynamics (MD) simulations have been carried out to investigate the characters of deoxythymidine triphosphate binding to two forms of nucleoprotein.
      Title: Studies on the binding modes of Lassa nucleoprotein complexed with m7GpppG and dTTP by molecular dynamic simulations and free energy calculations.
    5. Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy
      Title: Structure of the Lassa virus nucleoprotein revealed by X-ray crystallography, small-angle X-ray scattering, and electron microscopy.
    6. Residues D389 and G392 of nucleoprotein were critical for Lassa virus viability, while the D389A/G392A and D389T/392A double mutants were severely altered in the ability to suppress interferon in macrophages and dendritic cells.
      Title: Lassa virus nucleoprotein mutants generated by reverse genetics induce a robust type I interferon response in human dendritic cells and macrophages.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    nucleoprotein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004296.1 Reference assembly

      Range
      101..1810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_694869.1 nucleoprotein [Mammarenavirus lassaense]

      See identical proteins and their annotated locations for NP_694869.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P13699
      UniProtKB/TrEMBL
      A0A097F434, A0A097F435, F1D8L1, Q6GWS1
      Conserved Domains (2) summary
      pfam00843
      Location:4 → 339
      Arena_nucleocap; Arenavirus nucleocapsid N-terminal domain
      pfam17290
      Location:367 → 543
      Arena_ncap_C; Arenavirus nucleocapsid C-terminal domain
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAA46285.1
    AAT49003.1
    ADY11069.1
    ADY11071.1
    AEY85212.1
    APT69591.1
    APT69604.1
    APT69608.1
    APT69663.1
    QST04902.1

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials