U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    mug stationary phase mismatch/uracil DNA glycosylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947560, updated on 2-May-2024

    Summary

    Go to the top of the page Help
    Gene symbol
    mug
    Gene description
    stationary phase mismatch/uracil DNA glycosylase
    Primary source
    ASAP:ABE-0010073
    Locus tag
    b3068
    See related
    ECOCYC:EG12717
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3058; ygjF
    Summary
    Endonuclease IV stimulates Mug activity in vitro by promoting disassociation from the DNA and enzyme turnover. [More information is available at EcoGene: EG12717]. Mug is a glycosylase that acts in DNA repair . [More information is available at EcoCyc: EG12717].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (3214967..3215473, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA primase Neighboring gene RNA polymerase sigma factor RpoD Neighboring gene tRNA-Ile Neighboring gene NADPH-dependent ferric-chelate reductase

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway. Grippon S, et al. Nucleic Acids Res, 2011 Apr. PMID 21112870, Free PMC Article
    2. Identification of Escherichia coli mismatch-specific uracil DNA glycosylase as a robust xanthine DNA glycosylase. Lee HW, et al. J Biol Chem, 2010 Dec 31. PMID 20852254, Free PMC Article
    3. Mechanisms of base selection by the Escherichia coli mispaired uracil glycosylase. Liu P, et al. J Biol Chem, 2008 Apr 4. PMID 18208817, Free PMC Article
    4. Mismatch dependent uracil/thymine-DNA glycosylases excise exocyclic hydroxyethano and hydroxypropano cytosine adducts. Borys-Brzywczy E, et al. Acta Biochim Pol, 2005. PMID 15827614
    5. Role of mismatch-specific uracil-DNA glycosylase in repair of 3,N4-ethenocytosine in vivo. Jurado J, et al. DNA Repair (Amst), 2004 Dec 2. PMID 15474419

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E. coli MUG is able to excise 8oxoA in 8oxoA*T pairs.
      Title: 7,8-Dihydro-8-oxoadenine, a highly mutagenic adduct, is repaired by Escherichia coli and human mismatch-specific uracil/thymine-DNA glycosylases.
    2. Mug glycosylase is engaged in the repair of Etheno-DNA adducts.
      Title: The role of AlkB protein in repair of 1,N⁶-ethenoadenine in Escherichia coli cells.
    3. Mug binds its product cooperatively, and a stoichiometric analysis of DNA binding, catalytic activity and salt-dependence indicates that dimer formation is of functional significance in both catalytic activity and product binding.
      Title: Differential modes of DNA binding by mismatch uracil DNA glycosylase from Escherichia coli: implications for abasic lesion processing and enzyme communication in the base excision repair pathway.
    4. Escherichia coli mismatch-specific uracil DNA glycosylase is a robust xanthine DNA glycosylase
      Title: Identification of Escherichia coli mismatch-specific uracil DNA glycosylase as a robust xanthine DNA glycosylase.
    5. The enzymatic activity of E. coli mismatch-specific uracil-DNA glycosylase (MUG)can be complemented by human thymine-DNA glycosylase (hTDG).
      Title: Role of mismatch-specific uracil-DNA glycosylase in repair of 3,N4-ethenocytosine in vivo.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables G/U mismatch-specific uracil-DNA glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mismatch base pair DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables pyrimidine-specific mismatch base pair DNA N-glycosylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uracil DNA N-glycosylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in base-excision repair, AP site formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within base-excision repair, AP site formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in base-excision repair, AP site formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    stationary phase mismatch/uracil DNA glycosylase
    NP_417540.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3214967..3215473 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417540.1 stationary phase mismatch/uracil DNA glycosylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417540.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6L7CFQ5
      Conserved Domains (2) summary
      PRK10201
      Location:1 → 168
      PRK10201; G/U mismatch-specific DNA glycosylase
      cd10028
      Location:16 → 20
      UDG-F2_TDG_MUG; motif A [structural motif]
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.