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    ackA acetate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946775, updated on 19-Sep-2024

    Summary

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    Official Symbol
    ackA
    Official Full Name
    acetate kinase
    Primary source
    ECOCYC:EG10027
    Locus tag
    b2296
    See related
    ASAP:ABE-0007579
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2290
    Summary
    N-terminus is blocked (Fox, 86). [More information is available at EcoGene: EG10027]. Regulation has been described . [More information is available at EcoCyc: EG10027].
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    Genomic context

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    Sequence:
    NC_000913.3 (2413470..2414672)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene PF03887 family protein YfbU Neighboring gene PF04217 family membrane protein YfbV Neighboring gene phosphate acetyltransferase Neighboring gene putative transporter YfcC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evaluation of the phosphoryl-enzyme intermediate concept in the acetate kinase and hexokinase reactions from kinetic studies. Purich DL, et al. Arch Biochem Biophys, 1972 Mar. PMID 4552801
    2. Enzymatic phosphorylation of acetate. ROSE IA, et al. J Biol Chem, 1954 Dec. PMID 13221579
    3. Overproduction of acetate kinase activates the phosphate regulon in the absence of the phoR and phoM functions in Escherichia coli. Lee TY, et al. J Bacteriol, 1990 May. PMID 2158965, Free PMC Article
    4. Evidence that acetyl phosphate functions as a global signal during biofilm development. Wolfe AJ, et al. Mol Microbiol, 2003 May. PMID 12753190
    5. [Effect of the redox state of glutathione on acetate kinase activity in E. coli]. Kulis IuIu, et al. Biokhimiia, 1985 Feb. PMID 2985127

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Acetate and glucose fluxes in Escherichia coli are determined by the thermodynamic control of the Pta-AckA pathway.
      Title: Acetate fluxes in Escherichia coli are determined by the thermodynamic control of the Pta-AckA pathway.
    2. Deletion of the E. coli ackA gene (together with deletions of other ferementation disruption genes) increased production of succinate
      Title: Eliminating side products and increasing succinate yields in engineered strains of Escherichia coli C.
    3. pta/ackA recF mutants are viable, suggesting, together with the inviability of pta/ackA recBC mutants, that chromosomal lesions due to the pta/ackA defect are of the double-strand-break type.
      Title: A defect in the acetyl coenzyme A<-->acetate pathway poisons recombinational repair-deficient mutants of Escherichia coli.
    4. essential for anaerobic growth of E. coli on xylose due to energetic constraints
      Title: Pyruvate formate lyase and acetate kinase are essential for anaerobic growth of Escherichia coli on xylose.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables acetate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acetate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acetate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphotransferase activity, carboxyl group as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within acetate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in acetate metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in acetyl-CoA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in organic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within propionate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in single-species biofilm formation on inanimate substrate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 

    General protein information

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    Preferred Names
    acetate kinase
    NP_416799.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2413470..2414672
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416799.1 acetate kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416799.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A377D198, A0A5B9AH93
      Conserved Domains (1) summary
      PRK00180
      Location:4 → 399
      PRK00180; acetate kinase A/propionate kinase 2; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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