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    ndk nucleoside diphosphate kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945611, updated on 19-Sep-2024

    Summary

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    Official Symbol
    ndk
    Official Full Name
    nucleoside diphosphate kinase
    Primary source
    ECOCYC:EG10650
    Locus tag
    b2518
    See related
    ASAP:ABE-0008291
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2514
    Summary
    Binds TrxA (Kumar, 2004). [More information is available at EcoGene: EG10650]. Nucleoside diphosphate kinase catalyzes the reaction in which the terminal phosphate of a nucleoside-triphosphate is transferred to a nucleoside-diphosphate. [More information is available at EcoCyc: EG10650].
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    Genomic context

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    Sequence:
    NC_000913.3 (2644433..2644864, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytoskeleton protein RodZ Neighboring gene 23S rRNA m(2)A2503 methyltransferase/tRNA m(2)A37 methyltransferase Neighboring gene peptidoglycan glycosyltransferase PbpC Neighboring gene alpha2-macroglobulin

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nucleosidediphosphate kinase of Escherichia coli, a periplasmic enzyme. Roisin MP, et al. Biochim Biophys Acta, 1978 Oct 12. PMID 214126
    2. Escherichia coli nucleoside diphosphate kinase does not act as a uracil-processing DNA repair nuclease. Bennett SE, et al. Proc Natl Acad Sci U S A, 2004 Apr 27. PMID 15096615, Free PMC Article
    3. Escherichia coli nucleoside diphosphate kinase is a uracil-processing DNA repair nuclease. Postel EH, et al. Proc Natl Acad Sci U S A, 2003 Nov 11. PMID 14585934, Free PMC Article
    4. Metabolic functions of microbial nucleoside diphosphate kinases. Bernard MA, et al. J Bioenerg Biomembr, 2000 Jun. PMID 11768309
    5. Nucleoside diphosphate kinase from Escherichia coli. Almaula N, et al. J Bacteriol, 1995 May. PMID 7730286, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation rates and dNTP pool changes in ndk mutants
      Title: Mutational consequences of dNTP pool imbalances in E. coli.
    2. SOS induction of Y family polymerases is necessary to prevent mutagenesis in an ndk mutant background.
      Title: Escherichia coli nucleoside diphosphate kinase mutants depend on translesion DNA synthesis to prevent mutagenesis.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Nucleoside diphosphokinase: a functional link between intermediary metabolism and nucleic acid synthesis.
    4. In contrast to the robust uracil excision activity reported for E. coli NDK, the Mycobacterium tuberculosis NDK preparation exhibited very poor excision of uracil from DNA.
      Title: Mycobacterium tuberculosis and Escherichia coli nucleoside diphosphate kinases lack multifunctional activities to process uracil containing DNA.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleoside diphosphate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleoside diphosphate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleoside diphosphate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in CTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in UTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleotide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    nucleoside diphosphate kinase
    NP_417013.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2644433..2644864 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417013.1 nucleoside diphosphate kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417013.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W1ETF0
      Conserved Domains (1) summary
      PRK00668
      Location:3 → 135
      ndk; mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-; Validated
    Nucleotide Protein
    Heading Accession and Version

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