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    X X protein [ Hepatitis B virus ]

    Gene ID: 944566, updated on 28-Oct-2024

    Summary

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    Gene symbol
    X
    Gene description
    X protein
    Locus tag
    HBVgp3
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Hepatitis B virus (strain: ayw)
    Lineage
    Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes; Blubervirales; Hepadnaviridae; Orthohepadnavirus
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    Genomic context

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    Sequence:
    NC_003977.2 (1376..1840)

    NC_003977.2Genomic Context describing neighboring genes Neighboring gene large envelope protein;middle envelope protein;small envelope protein Neighboring gene polymerase Neighboring gene capsid protein;pre-capsid protein Neighboring gene polymerase Neighboring gene large envelope protein;middle envelope protein;small envelope protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003977.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination and degradation of HBx in hepatocellular carcinoma.
      Title: SIAH2 suppresses c-JUN pathway by promoting the polyubiquitination and degradation of HBx in hepatocellular carcinoma.
    2. JNK/c-Jun pathway activation is essential for HBx-induced IL-35 elevation to promote persistent HBV infection.
      Title: JNK/c-Jun pathway activation is essential for HBx-induced IL-35 elevation to promote persistent HBV infection.
    3. Hepatitis B Virus X Protein Inhibits the Expression of Barrier To Autointegration factor1 via Upregulating miR-203 Expression in Hepatic Cells.
      Title: Hepatitis B Virus X Protein Inhibits the Expression of Barrier To Autointegration factor1 via Upregulating miR-203 Expression in Hepatic Cells.
    4. Identification of critical residues in the regulatory protein HBx for Smc5/6 interaction and hepatitis B virus production.
      Title: Identification of critical residues in the regulatory protein HBx for Smc5/6 interaction and hepatitis B virus production.
    5. HBV X Protein Induces Degradation of UBXN7, a Novel Negative Regulator of NF-kappaB Signaling, to Promote HBV Replication.
      Title: HBV X Protein Induces Degradation of UBXN7, a Novel Negative Regulator of NF-κB Signaling, to Promote HBV Replication.
    6. Spatiotemporal modulation of SMAD4 by HBx is required for cellular proliferation in hepatitis B-related liver cancer.
      Title: Spatiotemporal modulation of SMAD4 by HBx is required for cellular proliferation in hepatitis B-related liver cancer.
    7. Hepatitis B virus X protein mediated epigenetic alterations in the pathogenesis of hepatocellular carcinoma.
      Title: Hepatitis B virus X protein mediated epigenetic alterations in the pathogenesis of hepatocellular carcinoma.
    8. Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA.
      Title: Hepatitis B virus X protein counteracts high mobility group box 1 protein-mediated epigenetic silencing of covalently closed circular DNA.
    9. HBX suppresses PTEN to promote the malignant progression of hepatocellular carcinoma through mi-R155 activation.
      Title: HBX suppresses PTEN to promote the malignant progression of hepatocellular carcinoma through mi-R155 activation.
    10. Novel X gene point mutations in chronic hepatitis B and HBV related cirrhotic patients.
      Title: Novel X gene point mutations in chronic hepatitis B and HBV related cirrhotic patients.
    Submit: New GeneRIF Correction See all GeneRIFs (431)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    regulatory

    • Loc: 1592-1602
    • Loc: 1775-1794
    • Loc: 1826-1836
    • Loc: 1834-1839

    General protein information

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    Preferred Names
    X protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003977.2 Reference assembly

      Range
      1376..1840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_009173867.1 X protein [Hepatitis B virus]

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A075T2U3, A0A075T2U6, A0A075T5M0, A0A075T610, A0A075T6T5, A0A075TD39, A0A0S3CUJ6, A0A1B2G2S2, A0A286QXD6, A0A2P1E6D4, C9WDD5, G9G967, G9I645, H6UMZ1, H6UN39, I1Z8G1, Q2F514, Q80IS1
    Nucleotide Protein
    Heading Accession and Version

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