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    Fez2 fasciculation and elongation protein zeta 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94269, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Fez2provided by RGD
    Official Full Name
    fasciculation and elongation protein zeta 2provided by RGD
    Primary source
    RGD:619709
    See related
    EnsemblRapid:ENSRNOG00000004577 AllianceGenome:RGD:619709
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Zrp
    Summary
    Predicted to be involved in negative regulation of autophagosome assembly. Predicted to be active in axon and cytoplasm. Orthologous to human FEZ2 (fasciculation and elongation protein zeta 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 121.3), Muscle (RPKM 117.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fez2 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (22406685..22446745)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (16654572..16694628)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (963903..1003955, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene striatin Neighboring gene vitrin Neighboring gene U2 spliceosomal RNA Neighboring gene cysteine rich transmembrane BMP regulator 1 Neighboring gene uncharacterized LOC120103478 Neighboring gene NSA2 ribosome biogenesis factor, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. mRNA expression of membrane-fusion-related proteins in rat parotid gland. Imai A, et al. Arch Oral Biol, 2001 Oct. PMID 11451410
    2. Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1. Fujita T, et al. Biochem Biophys Res Commun, 2004 Jan 16. PMID 14697253
    3. RAB3GAP1 and RAB3GAP2 modulate basal and rapamycin-induced autophagy. Spang N, et al. Autophagy, 2014. PMID 25495476, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FEZ2 plays an important role in the morphological changes of various cells by associating with PKCzeta in a tissue-non-specific manner
      Title: Identification of a tissue-non-specific homologue of axonal fasciculation and elongation protein zeta-1.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112579

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of autophagosome assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of autophagosome assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    fasciculation and elongation protein zeta-2
    Names
    synaptotagmin interacting protein zyginII
    zygin II
    zygin-2
    zygin-related protein types I/II

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001414905.1 → NP_001401834.1  fasciculation and elongation protein zeta-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      Q498V3

    2. NM_053600.3 → NP_446052.2  fasciculation and elongation protein zeta-2 isoform 1

      See identical proteins and their annotated locations for NP_446052.2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P97578, Q76LN1, Q9JJ35, Q9JJ36
      UniProtKB/TrEMBL
      A6H9W4
      Related
      ENSRNOP00000075253.3, ENSRNOT00000082071.3
      Conserved Domains (1) summary
      pfam07763
      Location:42 → 265
      FEZ; FEZ-like protein

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      22406685..22446745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262567.1 → XP_063118637.1  fasciculation and elongation protein zeta-2 isoform X2

    2. XM_006239639.5 → XP_006239701.3  fasciculation and elongation protein zeta-2 isoform X1

      UniProtKB/TrEMBL
      F7EYQ2
      Conserved Domains (1) summary
      pfam07763
      Location:66 → 289
      FEZ; FEZ-like protein

    RNA

    1. XR_010052153.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P97578.2 GenPept UniProtKB/Swiss-Prot:P97578

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials