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    Zfp423 zinc finger protein 423 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 94188, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Zfp423provided by RGD
    Official Full Name
    zinc finger protein 423provided by RGD
    Primary source
    RGD:621664
    See related
    EnsemblRapid:ENSRNOG00000014658 AllianceGenome:RGD:621664
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Roaz; Znf423
    Summary
    Enables identical protein binding activity and sequence-specific DNA binding activity. Involved in negative regulation of DNA-templated transcription. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in nephronophthisis 14. Orthologous to human ZNF423 (zinc finger protein 423). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 52.6), Brain (RPKM 50.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp423 in Genome Data Viewer
    Location:
    19p11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (35282149..35580775)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (19111213..19407373)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (20147201..20405999)

    Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108348906 Neighboring gene CTD nuclear envelope phosphatase 1 regulatory subunit 1 Neighboring gene mRNA turnover 4, ribosome maturation factor, pseudogene 7 Neighboring gene basic proline-rich protein-like Neighboring gene uncharacterized LOC134483302 Neighboring gene uncharacterized LOC134483301 Neighboring gene uncharacterized LOC120098541

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of DNA recognition sequences and protein interaction domains of the multiple-Zn-finger protein Roaz. Tsai RY, et al. Mol Cell Biol, 1998 Nov. PMID 9774661, Free PMC Article
    2. Zfp423 Maintains White Adipocyte Identity through Suppression of the Beige Cell Thermogenic Gene Program. Shao M, et al. Cell Metab, 2016 Jun 14. PMID 27238639, Free PMC Article
    3. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Hata A, et al. Cell, 2000 Jan 21. PMID 10660046
    4. Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development. Tsai RY, et al. J Neurosci, 1997 Jun 1. PMID 9151733, Free PMC Article
    5. ZFP423 coordinates Notch and bone morphogenetic protein signaling, selectively up-regulating Hes5 gene expression. Masserdotti G, et al. J Biol Chem, 2010 Oct 1. PMID 20547764, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein-containing complex binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Notch signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Notch signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in brown fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in brown fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cerebellar granule cell precursor proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cerebellar granule cell precursor proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of BMP signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of BMP signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of BMP signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein localization to cilium IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein localization to cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in white fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in white fat cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 423
    Names
    Olf-1/EBF associated Zn finger protein Roaz
    olf1/EBF-associated zinc finger protein
    smad- and Olf-interacting zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001393718.1 → NP_001380647.1  zinc finger protein 423

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000019
      UniProtKB/Swiss-Prot
      O08961, Q63681
      UniProtKB/TrEMBL
      A0A8I5ZY81
      Related
      ENSRNOP00000085196.2, ENSRNOT00000101895.2
      Conserved Domains (2) summary
      COG5048
      Location:202 → 603
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:148 → 168
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086037.1 Reference GRCr8

      Range
      35282149..35580775
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063278334.1 → XP_063134404.1  zinc finger protein 423 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A1R1, A6KDA7
      Related
      ENSRNOP00000107589.1, ENSRNOT00000153975.1

    2. XM_063278328.1 → XP_063134398.1  zinc finger protein 423 isoform X1

    3. XM_063278329.1 → XP_063134399.1  zinc finger protein 423 isoform X2

    4. XM_063278333.1 → XP_063134403.1  zinc finger protein 423 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A1R1, A6KDA7

    5. XM_063278330.1 → XP_063134400.1  zinc finger protein 423 isoform X2

    6. XM_063278332.1 → XP_063134402.1  zinc finger protein 423 isoform X2

    7. XM_063278331.1 → XP_063134401.1  zinc finger protein 423 isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_053583.2: Suppressed sequence

      Description
      NM_053583.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O08961.2 GenPept UniProtKB/Swiss-Prot:O08961

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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