RPS19BP1 ribosomal protein S19 binding protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPS19BP1provided by HGNC
Official Full Name: ribosomal protein S19 binding protein 1provided by HGNC
Primary source: HGNC:HGNC:28749
See related: Ensembl:ENSG00000187051 MIM:610225; AllianceGenome:HGNC:28749
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AROS; S19BP
Summary: Enables enzyme binding activity. Involved in ribosomal small subunit biogenesis. Located in cytosol; nucleolus; and nucleoplasm. Part of small-subunit processome. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in kidney (RPKM 26.6), prostate (RPKM 24.3) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 22q13.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	22	NC_000022.11 (39529093..39532748, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	22	NC_060946.1 (39999723..40003378, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	22	NC_000022.10 (39925098..39928753, complement)

Chromosome 22 - NC_000022.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein.
Title: Molecular Mechanism of Sirtuin 1 Modulation by the AROS Protein.
Results provide evidence that RomA methylates AROS, a nonhistone target, during infection of human cells.
Title: The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection.
AROS is a significant biomarker for tumor aggressiveness in non-cirrhotic hepatocellular carcinoma.
Title: AROS Is a Significant Biomarker for Tumor Aggressiveness in Non-cirrhotic Hepatocellular Carcinoma.
In vitro SIRT1 activity assays disclose AROS as an inhibitor of SIRT1.
Title: AROS has a context-dependent effect on SIRT1.
study demonstrated a cancer-specific role for AROS in the regulation of survival in a panel of human cell lines; data suggest that AROS, as well as SIRT1, promotes survival in cancer cells while being redundant for viability in non-cancer cells
Title: Active regulator of SIRT1 is required for cancer cell survival but not for SIRT1 activity.
This study analyses Sirt1 modulation by several putative Sirt1 regulators, showing that the regulator protein AROS has an unusual conformation and that the Sirt1 catalytic domain is sufficient for modulation by resveratrol.
Title: Molecular architecture of the human protein deacetylase Sirt1 and its regulation by AROS and resveratrol.
we found that the SIRT1 modulators AROS and DBC1 have an impact on hsp70 transcription, HSF1 acetylation status, and HSF1 recruitment to the hsp70 promoter.
Title: The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response.
Active regulator of SIRT1 (AROS) is the first direct SIRT1 regulator to be identified that modulates p53-mediated growth regulation.
Title: Active regulator of SIRT1 cooperates with SIRT1 and facilitates suppression of p53 activity.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-W60308 (e-PCR)
- UniSTS:73993

RH41880 (e-PCR)
- UniSTS:73836

WI-18448 (e-PCR)
- UniSTS:14496

GDB:335751 (e-PCR)
- UniSTS:156601

RH78005 (e-PCR)
- UniSTS:55266

D11S3316 (e-PCR)
- UniSTS:152558

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables enzyme binding	IBA Inferred from Biological aspect of Ancestor more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in ribosomal small subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: active regulator of SIRT1

Names: 40S ribosomal protein S19-binding protein 1; RPS19-binding protein 1; homolog of mouse S19 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_194326.4 → NP_919307.1 active regulator of SIRT1

See identical proteins and their annotated locations for NP_919307.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript and encodes the functional protein.

Source sequence(s)

BC037573

Consensus CDS

CCDS13997.1

UniProtKB/Swiss-Prot

B0QY96, Q5JZA1, Q86WX3

Related

ENSP00000333948.3, ENST00000334678.8

Conserved Domains (1) summary

pfam15684
Location:24 → 133

AROS; Active regulator of SIRT1, or 40S ribosomal protein S19-binding 1

RNA

NR_130151.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (2) includes an alternate exon, compared to variant 1. This variant is represented as non-coding because use of the supported translation start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

BQ675376, CB142920

Related

ENST00000420879.5