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    VP40 matrix protein [ Zaire ebolavirus ]

    Gene ID: 911825, updated on 18-Aug-2023

    Summary

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    Gene symbol
    VP40
    Gene description
    matrix protein
    Locus tag
    ZEBOVgp3
    Gene type
    protein coding
    RNA name
    VP40
    RefSeq status
    PROVISIONAL
    Organism
    Zaire ebolavirus (isolate: Ebola virus/H.sapiens-tc/COD/1976/Yambuku-Mayinga)
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Mononegavirales; Filoviridae; Ebolavirus
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    Genomic context

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    Sequence:
    NC_002549.1 (4390..5894)

    NC_002549.1Genomic Context describing neighboring genes Neighboring gene nucleoprotein Neighboring gene polymerase complex protein Neighboring gene second secreted glycoprotein;small secreted glycoprotein;spike glycoprotein Neighboring gene minor nucleoprotein Neighboring gene membrane-associated protein Neighboring gene RNA-dependent RNA polymerase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_002549.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cysteine Mutations in the Ebolavirus Matrix Protein VP40 Promote Phosphatidylserine Binding by Increasing the Flexibility of a Lipid-Binding Loop. Johnson KA, et al. Viruses, 2021 Jul 15. PMID 34372582, Free PMC Article
    2. Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form. Landeras-Bueno S, et al. Cell Rep, 2021 Apr 13. PMID 33852858, Free PMC Article
    3. Roles of YIGL sequence of Ebola virus VP40 on genome replication and particle production. Urata S, et al. J Gen Virol, 2019 Jul. PMID 31184566
    4. Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments. Gc JB, et al. Biochem Biophys Res Commun, 2017 Nov 4. PMID 28917841, Free PMC Article
    5. Label free checkerboard assay to determine overlapping epitopes of Ebola virus VP-40 antibodies using surface plasmon resonance. Anderson GP, et al. J Immunol Methods, 2017 Mar. PMID 28109682

    See all (62) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form.
      Title: Cellular mRNA triggers structural transformation of Ebola virus matrix protein VP40 to its essential regulatory form.
    2. Cysteine Mutations in the Ebolavirus Matrix Protein VP40 Promote Phosphatidylserine Binding by Increasing the Flexibility of a Lipid-Binding Loop.
      Title: Cysteine Mutations in the Ebolavirus Matrix Protein VP40 Promote Phosphatidylserine Binding by Increasing the Flexibility of a Lipid-Binding Loop.
    3. Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs.
      Title: Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs.
    4. Proximity proteomics identifies novel function of Rab14 in trafficking of Ebola virus matrix protein VP40.
      Title: Proximity proteomics identifies novel function of Rab14 in trafficking of Ebola virus matrix protein VP40.
    5. VP40 YIGL sequence regulates viral replication, virus particle production and genome replication/transcription.
      Title: Roles of YIGL sequence of Ebola virus VP40 on genome replication and particle production.
    6. Data show that the recombinant Ebolavirus nucleoprotein (NP) and the viral matrix protein VP40, which binds with NP, were acetylated by human histone acetyltransferases.
      Title: Acetylation of lysine residues in the recombinant nucleoprotein and VP40 matrix protein of Zaire Ebolavirus by eukaryotic histone acetyltransferases.
    7. Modulation of the VP40-SUMO (SUMOylation) interaction may represent a novel target for the therapy of Ebola virus infection.
      Title: Regulation of Ebola virus VP40 matrix protein by SUMO.
    8. This VP40 hexamer-hexamer interface is crucial in forming the Ebola viral matrix and disruption of this interface may provide a method to use graphene or similar nanoparticle based solutions as a disinfectant that can significantly reduce the spread of the disease and prevent an Ebola epidemic.
      Title: Graphene-VP40 interactions and potential disruption of the Ebola virus matrix filaments.
    9. Interdomain salt-bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization.
      Title: Interdomain salt-bridges in the Ebola virus protein VP40 and their role in domain association and plasma membrane localization.
    10. Analysis of binding utilizing surface plasmon resonance for several mAbs and sdAb specific for VP40 from Ebola virus.
      Title: Label free checkerboard assay to determine overlapping epitopes of Ebola virus VP-40 antibodies using surface plasmon resonance.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    General gene information

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    Homology

    regulatory

    • Loc: 4390-4401 regulatory_class = other
    • Loc: 4397-4407 regulatory_class = polyA_signal_sequence
    • Loc: 5883-5894 regulatory_class = polyA_signal_sequence

    General protein information

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    Preferred Names
    matrix protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_002549.1 Reference assembly

      Range
      4390..5894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_066245.1 matrix protein [Zaire ebolavirus]

      See identical proteins and their annotated locations for NP_066245.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q05128, Q77DJ6
      UniProtKB/TrEMBL
      A0A096YGW8, A0A0E3KN52, A0A0U2JQR9, A0A1L7B8D9, A0A2Z2FH29, A9QPL8, L7QHU6, L7QHW4, L7QI94
      Conserved Domains (1) summary
      pfam07447
      Location:27 → 295
      VP40; Matrix protein VP40
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAD14583.1

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