Trpc1 transient receptor potential cation channel, subfamily C, member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Trpc1provided by RGD
Full Name: transient receptor potential cation channel, subfamily C, member 1provided by RGD
Primary source: RGD:619783
See related: EnsemblRapid:ENSRNOG00000054902 AllianceGenome:RGD:619783
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Trrp1
Summary: Predicted to enable several functions, including ATPase binding activity; inositol 1,4,5 trisphosphate binding activity; and store-operated calcium channel activity. Involved in cellular response to hypoxia and modulation of chemical synaptic transmission. Is active in postsynaptic membrane and presynaptic membrane. Biomarker of type 2 diabetes mellitus. Orthologous to human TRPC1 (transient receptor potential cation channel subfamily C member 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 76.3), Heart (RPKM 61.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (105142931..105193842, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (96263322..96314220, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (103503982..103554905, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Robust expression of the TRPC1 channel associated with photoreceptor loss in the rat retina.
Title: Robust expression of the TRPC1 channel associated with photoreceptor loss in the rat retina.
Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels.
Title: Cardiac hypertrophy caused by hyperthyroidism in rats: the role of ATF-6 and TRPC1 channels.
TRPC1-mediated Ca(2+) signaling enhances intestinal epithelial restitution by increasing alpha4 association with PP2Ac after wounding.
Title: TRPC1-mediated Ca(2+) signaling enhances intestinal epithelial restitution by increasing α4 association with PP2Ac after wounding.
TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons.
Title: TRPC1 mediates slow excitatory synaptic transmission in hippocampal oriens/alveus interneurons.
Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.
Title: Location and function of transient receptor potential canonical channel 1 in ventricular myocytes.
Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes.
Title: Specific Upregulation of TRPC1 and TRPC5 Channels by Mineralocorticoid Pathway in Adult Rat Ventricular Cardiomyocytes.
STIM1L/Orai1/TRPC1/C4-dependent Ca(2+) current participates in Ca(2+) remodeling in right ventricular hypertrophy secondary to pulmonary hypertension.
Title: Ca(2+) handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.
In the trigeminal ganglion (TG), 56.1, 84.1, and 68.3% of sensory neurons were immunoreactive (IR) for TRPC1, TRPC3, and TRPC4, respectively.
Title: TRPC1, TRPC3, and TRPC4 in Rat Orofacial Structures.
1) TRPC1/4 exert protective effects against SAH-induecd EBI, including cortical cell death and degenerating; 2) TRPC1/4 positively regulated the activity of calcineurin. 3) TRPC1/4 promoted the dephosphorylation of NMDAR via calcineurin.
Title: Transient receptor potential channel 1/4 reduces subarachnoid hemorrhage-induced early brain injury in rats via calcineurin-mediated NMDAR and NFAT dephosphorylation.
the altered expressions of PPARgamma, TRPC1 and TRPC6 in the pulmonary artery located in the lungs of newborn rats with Persistent pulmonary hypertension of the newborn (PPHN) suggested that these proteins may be important mediators of PPHN.
Title: Altered expression of PPAR‑γ and TRPC in neonatal rats with persistent pulmonary hypertension.

Submit: New GeneRIF Correction See all GeneRIFs (62)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH134083 (e-PCR)
- UniSTS:217365

Trpc1 (e-PCR), detects polymorphism
- UniSTS:531238

RH144273 (e-PCR)
- UniSTS:233518

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

UniSTS:236220 (e-PCR)
- UniSTS:236220

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase binding	IEA Inferred from Electronic Annotation more info
enables ATPase binding	ISO Inferred from Sequence Orthology more info
enables calcium channel activity	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables inositol 1,4,5 trisphosphate binding	IEA Inferred from Electronic Annotation more info
enables inositol 1,4,5 trisphosphate binding	ISO Inferred from Sequence Orthology more info
enables monoatomic cation channel activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables store-operated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables store-operated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables transmembrane transporter binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in melanin biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in regulation of cytosolic calcium ion concentration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytosolic calcium ion concentration	IEA Inferred from Electronic Annotation more info
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in relaxation of vascular associated smooth muscle	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	IEA Inferred from Electronic Annotation more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within saliva secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
part_of cation channel complex	IBA Inferred from Biological aspect of Ancestor more info
located_in costamere	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of receptor complex	IEA Inferred from Electronic Annotation more info
part_of receptor complex	ISO Inferred from Sequence Orthology more info
located_in sarcomere	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: short transient receptor potential channel 1

Names: TRP-1; short transient receptor potential channel 1-like; transient receptor protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001413355.1 → NP_001400284.1 short transient receptor potential channel 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A0A0G2K7J3

Related

ENSRNOP00000074229.3, ENSRNOT00000089833.3
NM_001429254.1 → NP_001416183.1 short transient receptor potential channel 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/TrEMBL

A6I264
NM_053558.3 → NP_446010.2 short transient receptor potential channel 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

Q9QX01

Related

ENSRNOP00000072139.2, ENSRNOT00000079965.3

Conserved Domains (2) summary

TIGR00870
Location:48 → 740

trp; transient-receptor-potential calcium channel protein

sd00045
Location:83 → 117

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

105142931..105193842 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039082220.2 → XP_038938148.1 short transient receptor potential channel 1 isoform X5

UniProtKB/Swiss-Prot

Q9QX01

Conserved Domains (1) summary

TIGR00870
Location:25 → 661

trp; transient-receptor-potential calcium channel protein
XM_063266254.1 → XP_063122324.1 short transient receptor potential channel 1 isoform X2
XM_063266253.1 → XP_063122323.1 short transient receptor potential channel 1 isoform X1
XM_063266255.1 → XP_063122325.1 short transient receptor potential channel 1 isoform X6
XM_039082218.2 → XP_038938146.1 short transient receptor potential channel 1 isoform X3

UniProtKB/TrEMBL

Q0PG39

Conserved Domains (1) summary

TIGR00870
Location:14 → 695

trp; transient-receptor-potential calcium channel protein
XM_039082219.2 → XP_038938147.1 short transient receptor potential channel 1 isoform X4

UniProtKB/Swiss-Prot

Q9QX01

Conserved Domains (1) summary

TIGR00870
Location:48 → 684

trp; transient-receptor-potential calcium channel protein