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    Gyc76C Guanylyl cyclase at 76C [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 8674026, updated on 7-Jul-2024

    Summary

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    Official Symbol
    Gyc76Cprovided by FlyBase
    Official Full Name
    Guanylyl cyclase at 76Cprovided by FlyBase
    Primary source
    FLYBASE:FBgn0266136
    Locus tag
    Dmel_CG42636
    See related
    AllianceGenome:FB:FBgn0266136
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG32215; CG42636; CG8742; DGC1; Dmel\CG42636; drgc; DrGC-1; gim; GYC 76C; gyc76C; l(3)76BDl; l(3)L0090
    Old locus tag
    Dmel_CG8742
    Summary
    Enables guanylate cyclase activity; peptide receptor activity; and semaphorin receptor binding activity. Involved in several processes, including axon guidance; larval somatic muscle development; and primary branching, open tracheal system. Is integral component of plasma membrane. Is expressed in several structures, including adult head; digestive system; dorsal closure embryo; germline cell; and muscle system. Human ortholog(s) of this gene implicated in congenital diarrhea 6. Orthologous to human GUCY2C (guanylate cyclase 2C). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Gyc76C in Genome Data Viewer
    Location:
    76C3-76C5; 3-46 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (19750943..19793569, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (19744043..19786669, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Viral tegument-like deubiquitinase Neighboring gene Sterol regulatory element binding protein Neighboring gene uncharacterized protein Neighboring gene mir-33 stem loop Neighboring gene Ionotropic receptor 76a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Molecular characterization of two Drosophila guanylate cyclases expressed in the nervous system. Liu W, et al. J Biol Chem, 1995 May 26. PMID 7759483
    2. Identification, characterization, and developmental regulation of a receptor guanylyl cyclase expressed during early stages of Drosophila development. McNeil L, et al. J Biol Chem, 1995 Mar 31. PMID 7706258
    3. Receptor-Type Guanylyl Cyclase at 76C (Gyc76C) Regulates De Novo Lumen Formation during Drosophila Tracheal Development. Myat MM, et al. PLoS One, 2016. PMID 27642749, Free PMC Article
    4. Genetic, molecular and physiological basis of variation in Drosophila gut immunocompetence. Bou Sleiman MS, et al. Nat Commun, 2015 Jul 27. PMID 26213329, Free PMC Article
    5. Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance. Chak K, et al. Development, 2014 Jan. PMID 24284209, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A Receptor Guanylate Cyclase, Gyc76C, Mediates Humoral, and Cellular Responses in Distinct Ways in Drosophila Immunity.
      Title: A Receptor Guanylate Cyclase, Gyc76C, Mediates Humoral, and Cellular Responses in Distinct Ways in Drosophila Immunity.
    2. These studies show that Gyc76C and downstream protein kinase G-dependent signaling regulate de novo lumen formation in the tracheal Dorsal trunk and terminal cells, most likely by affecting Arl3-mediated luminal secretion.
      Title: Receptor-Type Guanylyl Cyclase at 76C (Gyc76C) Regulates De Novo Lumen Formation during Drosophila Tracheal Development.
    3. We show that Gyc76C and the soluble cGMP-dependent kinase Foraging, likely linked by cGMP, are necessary for normal refinement and maintenance of long-range BMP signaling in the posterior crossvein
      Title: The Gyc76C Receptor Guanylyl Cyclase and the Foraging cGMP-Dependent Kinase Regulate Extracellular Matrix Organization and BMP Signaling in the Developing Wing of Drosophila melanogaster.
    4. Gyc76C genetically interacts with Semaphorin 1a and physically associates with the Sema-1a receptor plexin A.
      Title: Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c19776073-19771346 mobile_element_type = transposon:Doc{}1053

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables guanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables peptide receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables peptide receptor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphorus-oxygen lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables semaphorin receptor binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axon guidance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon midline choice point recognition IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cGMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cyclic nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in extracellular matrix organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in larval somatic muscle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in motor neuron axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in primary branching, open tracheal system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in receptor guanylyl cyclase signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor guanylyl cyclase signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of BMP signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to salt stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in salivary gland morphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in salivary gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    guanylyl cyclase at 76C
    Names
    CG42636-PA
    CG42636-PB
    CG42636-PC
    CG42636-PD
    Gyc76C-PA
    Gyc76C-PB
    Gyc76C-PC
    Gyc76C-PD
    gimli
    l(3)76BDl
    lethal (3) L0090
    receptor-type guanylate cyclase
    NP_001163473.1
    NP_001163474.1
    NP_001163475.1
    NP_001262063.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      19750943..19793569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001170003.2 → NP_001163474.1  guanylyl cyclase at 76C, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163474.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24051, Q7JQ32
      UniProtKB/TrEMBL
      A4V243
      Conserved Domains (6) summary
      cd06370
      Location:26 → 445
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00044
      Location:860 → 1052
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:543 → 827
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:887 → 1074
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:48 → 412
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:835 → 881
      HNOBA; Heme NO binding associated

    2. NM_001170004.2 → NP_001163475.1  guanylyl cyclase at 76C, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163475.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24051, Q7JQ32
      UniProtKB/TrEMBL
      A4V243
      Conserved Domains (6) summary
      cd06370
      Location:26 → 445
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00044
      Location:860 → 1052
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:543 → 827
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:887 → 1074
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:48 → 412
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:835 → 881
      HNOBA; Heme NO binding associated

    3. NM_001275134.1 → NP_001262063.1  guanylyl cyclase at 76C, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262063.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24051, Q7JQ32
      UniProtKB/TrEMBL
      A4V243
      Conserved Domains (6) summary
      cd06370
      Location:26 → 445
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00044
      Location:860 → 1052
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:543 → 827
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:887 → 1074
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:48 → 412
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:835 → 881
      HNOBA; Heme NO binding associated

    4. NM_001170002.1 → NP_001163473.1  guanylyl cyclase at 76C, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001163473.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q24051, Q7JQ32
      UniProtKB/TrEMBL
      A4V243
      Conserved Domains (6) summary
      cd06370
      Location:26 → 445
      PBP1_Speract_GC_like; Ligand-binding domain of membrane bound guanylyl cyclases
      smart00044
      Location:860 → 1052
      CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
      cd14042
      Location:543 → 827
      PK_GC-A_B; Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B
      pfam00211
      Location:887 → 1074
      Guanylate_cyc; Adenylate and Guanylate cyclase catalytic domain
      pfam01094
      Location:48 → 412
      ANF_receptor; Receptor family ligand binding region
      pfam07701
      Location:835 → 881
      HNOBA; Heme NO binding associated
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7JQ32.1 Q7JQ32

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