SCH9 serine/threonine protein kinase SCH9 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: SCH9
Official Full Name: serine/threonine protein kinase SCH9
Primary source: SGD:S000001248
Locus tag: YHR205W
See related: AllianceGenome:SGD:S000001248; FungiDB:YHR205W; VEuPathDB:YHR205W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: HRM2; KOM1
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including positive regulation of DNA-templated transcription; regulation of sphingolipid biosynthetic process; and regulation of sulfur metabolic process. Located in chromatin; fungal-type vacuole membrane; and nucleus. Human ortholog(s) of this gene implicated in several diseases, including breast cancer (multiple); colorectal cancer (multiple); glucose metabolism disease (multiple); pancreatic cancer (multiple); and reproductive organ cancer (multiple). Orthologous to several human genes including AKT1 (AKT serine/threonine kinase 1); AKT2 (AKT serine/threonine kinase 2); and AKT3 (AKT serine/threonine kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See SCH9 in Genome Data Viewer

Location:: chromosome: VIII

Exon count:: 1

Sequence:: Chromosome: VIII; NC_001140.6 (509363..511837)

Chromosome VIII - NC_001140.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sch9[S6K] controls DNA repair and DNA damage response efficiency in aging cells.
Title: Sch9(S6K) controls DNA repair and DNA damage response efficiency in aging cells.
Vacuolar Localization via the N-terminal Domain of Sch9 is Required for TORC1-dependent Phosphorylation and Downstream Signal Transduction.
Title: Vacuolar Localization via the N-terminal Domain of Sch9 is Required for TORC1-dependent Phosphorylation and Downstream Signal Transduction.
Nutrient transceptors physically interact with the yeast S6/protein kinase B homolog, Sch9, a TOR kinase target.
Title: Nutrient transceptors physically interact with the yeast S6/protein kinase B homolog, Sch9, a TOR kinase target.
Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response.
Title: Histone H3 threonine 11 phosphorylation by Sch9 and CK2 regulates chronological lifespan by controlling the nutritional stress response.
The Sch9 branch integrates the intrinsic activity of TORC1 kinase and vacuolar status, which is monitored by the phospholipids of the vacuolar membrane, into the regulation of macromolecular synthesis.
Title: Vacuole-mediated selective regulation of TORC1-Sch9 signaling following oxidative stress.
results suggest that Sch9p pathways modulate acetic acid-induced cell death, through the regulation of Isc1p cellular distribution, thus affecting the sphingolipid balance that regulates cell fate.
Title: Acetic acid induces Sch9p-dependent translocation of Isc1p from the endoplasmic reticulum into mitochondria.
Findings demonstrate the ability of the Sch9 protein to form specific intracellular structures, at least some of which possess amyloid-like properties. In addition, Sch9 overproduction was found to cause cell elongation, and this effect was determined by its C-terminal region containing kinase domains.
Title: Overproduction of Sch9 leads to its aggregation and cell elongation in Saccharomyces cerevisiae.
Data show that the absence of either Ssb1/2 or Sch9 causes enhanced ribosome aggregation.
Title: The Hsp70 homolog Ssb affects ribosome biogenesis via the TORC1-Sch9 signaling pathway.
We also show that Tor1p vacuolar localization and TORC1 anabolic functions, including growth promotion and phosphorylation of its direct substrate Sch9, are compromised in s-hhy mutants. Thus, an intact trans-Golgi and late endosome interface is a requisite for efficient Tor1 vacuolar localization and TORC1 function.
Title: Hygromycin B hypersensitive (hhy) mutants implicate an intact trans-Golgi and late endosome interface in efficient Tor1 vacuolar localization and TORC1 function.
SCH9 deletion causes the upregulation of many amino acid biosynthesis pathways and increases glycerol during fermentation. When Gcn4p was overexpressed during winemaking, increased glycerol production was also observed.
Title: Sch9p kinase and the Gcn4p transcription factor regulate glycerol production during winemaking.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hydrogen sulfide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ribosomal protein gene transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase I	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase III	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription by RNA polymerase III	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell size	HMP more info	PubMed
involved_in regulation of cysteine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sphingolipid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chromatin	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
located_in fungal-type vacuole membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: serine/threonine protein kinase SCH9

NP_012075.1

EC 2.7.11.1

AGC family protein kinase; functional ortholog of mammalian S6 kinase; phosphorylated by Tor1p and required for TORC1-mediated regulation of ribosome biogenesis, translation initiation, and entry into G0 phase; involved in transactivation of osmostress-responsive genes; regulates G1 progression, cAPK activity and nitrogen activation of the FGM pathway; integrates nutrient signals and stress signals from sphingolipids to regulate lifespan

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001140.6 Reference assembly

Range

509363..511837

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001179336.1 → NP_012075.1 TPA: serine/threonine protein kinase SCH9 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012075.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D3DLF4, P11792

UniProtKB/TrEMBL

A6ZTB2, B3LSW6, C8ZA06, N1P1D0

Conserved Domains (2) summary

cd11651
Location:181 → 407

YPK1_N_like; Fungal protein kinase domain similar to the N-terminus of YPK1

cd05586
Location:418 → 738

STKc_Sck1_like; Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases