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    SCS7 fatty acid alpha-hydroxylase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855315, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SCS7
    Official Full Name
    fatty acid alpha-hydroxylase
    Primary source
    SGD:S000004885
    Locus tag
    YMR272C
    See related
    AllianceGenome:SGD:S000004885; FungiDB:YMR272C; VEuPathDB:YMR272C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FAH1
    Summary
    Enables fatty acid 2-hydroxylase activity and sphingosine hydroxylase activity. Involved in inositol phosphoceramide metabolic process and very long-chain fatty acid metabolic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 35. Orthologous to human FA2H (fatty acid 2-hydroxylase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SCS7 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (809623..810777, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene orotate phosphoribosyltransferase URA10 Neighboring gene tRNA-Gln Neighboring gene uncharacterized protein Neighboring gene Zds1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Levels of SCS7/FA2H-mediated fatty acid 2-hydroxylation determine the sensitivity of cells to antitumor PM02734. Herrero AB, et al. Cancer Res, 2008 Dec 1. PMID 19047157
    2. Mass spectrometry-based profiling of phospholipids and sphingolipids in extracts from Saccharomyces cerevisiae. Guan XL, et al. Yeast, 2006 Apr 30. PMID 16652392
    3. Requirement of sphingolipid alpha-hydroxylation for fungicidal action of syringomycin E. Hama H, et al. FEBS Lett, 2000 Jul 28. PMID 10922463
    4. Synthesis of monohydroxylated inositolphosphorylceramide (IPC-C) in Saccharomyces cerevisiae requires Scs7p, a protein with both a cytochrome b5-like domain and a hydroxylase/desaturase domain. Dunn TM, et al. Yeast, 1998 Mar 15. PMID 9559540
    5. Following the flux of long-chain bases through the sphingolipid pathway in vivo using mass spectrometry. Martínez-Montañés F, et al. J Lipid Res, 2016 May. PMID 26977056, Free PMC Article

    See all (86) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables dihydroceramide fatty acyl 2-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid 2-hydroxylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acid 2-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid 2-hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sphingosine hydroxylase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular lipid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in inositol phosphoceramide metabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in inositol phosphoceramide metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in lipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in very long-chain fatty acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    fatty acid alpha-hydroxylase
    NP_013999.1
    • Sphingolipid alpha-hydroxylase; functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      809623..810777 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182779.1 → NP_013999.1  TPA: fatty acid alpha-hydroxylase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013999.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W098, Q03529
      UniProtKB/TrEMBL
      A6ZMY7, B3LMF9, C7GTM8, C8ZFD7, G2WKY0, N1NXQ7
      Conserved Domains (2) summary
      COG5274
      Location:31 → 224
      CYB5; Cytochrome b involved in lipid metabolism [Energy production and conversion, Lipid transport and metabolism]
      cl01132
      Location:149 → 380
      FA_hydroxylase; Fatty acid hydroxylase superfamily
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03529.1

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