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    SMF1 divalent metal ion transporter SMF1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854027, updated on 2-Nov-2024

    Summary

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    Official Symbol
    SMF1
    Official Full Name
    divalent metal ion transporter SMF1
    Primary source
    SGD:S000005482
    Locus tag
    YOL122C
    See related
    AllianceGenome:SGD:S000005482; FungiDB:YOL122C; VEuPathDB:YOL122C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SBS1
    Summary
    Enables solute:proton symporter activity. Involved in intracellular monoatomic cation homeostasis and transition metal ion transport. Located in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including anemia (multiple); autoimmune disease (multiple); inflammatory bowel disease (multiple); leishmaniasis (multiple); and tuberculosis (multiple). Orthologous to human SLC11A1 (solute carrier family 11 member 1) and SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SMF1 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (89692..91419, complement)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene tRNA (guanine-N2-)-methyltransferase Neighboring gene Hrp1p Neighboring gene ribosomal 40S subunit protein S19A Neighboring gene ribosomal 60S subunit protein L18A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The first external loop of the metal ion transporter DCT1 is involved in metal ion binding and specificity. Cohen A, et al. Proc Natl Acad Sci U S A, 2003 Sep 16. PMID 12954986, Free PMC Article
    2. Mutational analysis of Saccharomyces cerevisiae Smf1p, a member of the Nramp family of metal transporters. Liu XF, et al. J Mol Biol, 1999 Jun 18. PMID 10369769
    3. Divalent metal transport in the green microalga Chlamydomonas reinhardtii is mediated by a protein similar to prokaryotic Nramp homologues. Rosakis A, et al. Biometals, 2005 Feb. PMID 15865416
    4. Properties of the mammalian and yeast metal-ion transporters DCT1 and Smf1p expressed in Xenopus laevis oocytes. Sacher A, et al. J Exp Biol, 2001 Mar. PMID 11222124
    5. Yeast SMF1 mediates H(+)-coupled iron uptake with concomitant uncoupled cation currents. Chen XZ, et al. J Biol Chem, 1999 Dec 3. PMID 10574989

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cadmium ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic cation transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables solute:proton symporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cadmium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cadmium ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in copper ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular copper ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in intracellular manganese ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular manganese ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in iron ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in iron ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in manganese ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in manganese ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in manganese ion transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in metal ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in fungal-type vacuole HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    divalent metal ion transporter SMF1
    NP_014519.1
    • Divalent metal ion transporter; broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      89692..91419 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183376.1 → NP_014519.1  TPA: divalent metal ion transporter SMF1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014519.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1U6, P38925
      UniProtKB/TrEMBL
      G2WMB5, N1NXC6
      Conserved Domains (1) summary
      TIGR01197
      Location:74 → 490
      nramp; NRAMP (natural resistance-associated macrophage protein) metal ion transporters
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38925.2

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