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    ARO4 3-deoxy-7-phosphoheptulonate synthase ARO4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852551, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ARO4
    Official Full Name
    3-deoxy-7-phosphoheptulonate synthase ARO4
    Primary source
    SGD:S000000453
    Locus tag
    YBR249C
    See related
    AllianceGenome:SGD:S000000453; FungiDB:YBR249C; VEuPathDB:YBR249C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 3-deoxy-7-phosphoheptulonate synthase activity. Predicted to be involved in aromatic amino acid family biosynthetic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ARO4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (716882..717994, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene snoRNA-binding rRNA-processing protein ENP1 Neighboring gene imidazoleglycerol-phosphate synthase Neighboring gene Spo23p Neighboring gene mitochondrial 37S ribosomal protein MRPS5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Substrate and metal complexes of 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase from Saccharomyces cerevisiae provide new insights into the catalytic mechanism. König V, et al. J Mol Biol, 2004 Mar 26. PMID 15019786
    2. The two 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase isoenzymes from Saccharomyces cerevisiae show different kinetic modes of inhibition. Schnappauf G, et al. Arch Microbiol, 1998 Jun. PMID 9575238
    3. Genetic transformation of industrial yeasts using an amino acid analog resistance gene as a directly selectable marker. Shimura K, et al. Enzyme Microb Technol, 1993 Oct. PMID 7764106
    4. Feedback-insensitive mutants of the gene for the tyrosine-inhibited DAHP synthetase in yeast. Meuris P. Genetics, 1974 Apr. PMID 4599255, Free PMC Article
    5. A mutated ARO4 gene for feedback-resistant DAHP synthase which causes both o-fluoro-DL-phenylalanine resistance and beta-phenethyl-alcohol overproduction in Saccharomyces cerevisiae. Fukuda K, et al. Curr Genet, 1991 Dec. PMID 1723662

    See all (67) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 3-deoxy-7-phosphoheptulonate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3-deoxy-7-phosphoheptulonate synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-deoxy-7-phosphoheptulonate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in amino acid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aromatic amino acid family biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chorismate biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    3-deoxy-7-phosphoheptulonate synthase ARO4
    NP_009808.1
    • 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      716882..717994 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178597.1 → NP_009808.1  TPA: 3-deoxy-7-phosphoheptulonate synthase ARO4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009808.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQP5, P32449
      UniProtKB/TrEMBL
      A6ZLI8, B3LMR3, B5VEJ9, C7GMY2, D3UEZ6, G2W9Q2, N1P8J9
      Conserved Domains (1) summary
      TIGR00034
      Location:21 → 365
      aroFGH; phospho-2-dehydro-3-deoxyheptonate aldolase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32449.2

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