Mlycd malonyl-CoA decarboxylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mlycdprovided by RGD
Official Full Name: malonyl-CoA decarboxylaseprovided by RGD
Primary source: RGD:620234
See related: EnsemblRapid:ENSRNOG00000014522 AllianceGenome:RGD:620234
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mcd
Summary: Enables malonyl-CoA decarboxylase activity. Involved in several processes, including acetyl-CoA biosynthetic process; fatty acid metabolic process; and response to ischemia. Located in mitochondrial matrix and peroxisomal matrix. Biomarker of metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in cardiomyopathy. Orthologous to human MLYCD (malonyl-CoA decarboxylase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 434.6), Muscle (RPKM 258.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 19q12

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	19	NC_086037.1 (64356582..64372447)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	19	NC_051354.1 (47447931..47463794)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	19	NC_005118.4 (52032950..52048773)

Chromosome 19 - NC_086037.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Peroxisomal-proliferator-activated receptor alpha activates transcription of the hepatic malonyl-CoA decarboxylase gene.
Title: Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level.
Mlycd regulation in rat in response to exercise
Title: Coordinate regulation of malonyl-CoA decarboxylase, sn-glycerol-3-phosphate acyltransferase, and acetyl-CoA carboxylase by AMP-activated protein kinase in rat tissues in response to exercise.
substantial amounts of MCD protein and activity were found in the cytosol, mitochondria and peroxisomes, the latter with the highest specific activity
Title: Malonyl-CoA decarboxylase is present in the cytosolic, mitochondrial and peroxisomal compartments of rat hepatocytes.
Increasing myocardial malonyl CoA levels decreases fatty acid oxidation & accelerates glucose oxidation in ex vivo rat hearts This switch in energy substrate preference improves cardiac function during & after ischemia.
Title: Malonyl coenzyme a decarboxylase inhibition protects the ischemic heart by inhibiting fatty acid oxidation and stimulating glucose oxidation.
Genomic organization and characterization of the promoter of teh malonyl-CoA decarboxylase gene
Title: Genomic organization and characterization of the promoter of rat malonyl-CoA decarboxylase gene.
differential regulation of malonyl CoA decarboxylase expression and activity in the mitochondria by AMP kinase may potentially regulate malonyl-CoA levels at sites nearby CPT-I on the mitochondria
Title: Malonyl-CoA decarboxylase (MCD) is differentially regulated in subcellular compartments by 5'AMP-activated protein kinase (AMPK). Studies using H9c2 cells overexpressing MCD and AMPK by adenoviral gene transfer technique.

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General gene information

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Markers

RH144263 (e-PCR)
- UniSTS:233508

AI044337 (e-PCR)
- UniSTS:247965

Mlycd (e-PCR), detects polymorphism
- UniSTS:516513

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables malonyl-CoA decarboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables malonyl-CoA decarboxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables malonyl-CoA decarboxylase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acetyl-CoA biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in acetyl-CoA biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in acetyl-CoA biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fatty acid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in malonyl-CoA catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in malonyl-CoA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in malonyl-CoA catabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of fatty acid oxidation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of fatty acid oxidation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of fatty acid beta-oxidation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of fatty acid oxidation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucose metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of glucose metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to nutrient	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial matrix	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
is_active_in peroxisomal matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in peroxisomal matrix	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed
located_in peroxisome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: malonyl-CoA decarboxylase, mitochondrial

NP_445929.2

EC 4.1.1.9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053477.2 → NP_445929.2 malonyl-CoA decarboxylase, mitochondrial

Status: VALIDATED

Source sequence(s)

JAXUCZ010000019

UniProtKB/Swiss-Prot

Q920F5, Q9WUY2

UniProtKB/TrEMBL

A6IZI5

Related

ENSRNOP00000019923.3, ENSRNOT00000019923.7

Conserved Domains (2) summary

pfam05292
Location:192 → 455

MCD; Malonyl-CoA decarboxylase C-terminal domain

pfam17408
Location:94 → 189

MCD_N; Malonyl-CoA decarboxylase N-terminal domain