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    SMT3 SUMO family protein SMT3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852122, updated on 3-Nov-2024

    Summary

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    Official Symbol
    SMT3
    Official Full Name
    SUMO family protein SMT3
    Primary source
    SGD:S000002918
    Locus tag
    YDR510W
    See related
    AllianceGenome:SGD:S000002918; FungiDB:YDR510W; VEuPathDB:YDR510W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables protein tag activity. Involved in protein sumoylation. Located in condensed nuclear chromosome and septin ring. Used to study cancer. Human ortholog(s) of this gene implicated in orofacial cleft 10. Orthologous to several human genes including SUMO1P1 (SUMO1 pseudogene 1) and SUMO1 (small ubiquitin like modifier 1). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See SMT3 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (1469400..1469705)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene protein kinase GIN4 Neighboring gene glutamine permease GNP1 Neighboring gene Sdh7p Neighboring gene Emi1p Neighboring gene dithiol glutaredoxin GRX2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of SUMO conjugation sites in the budding yeast proteome. Esteras M, et al. Microb Cell, 2017 Oct 2. PMID 29082231, Free PMC Article
    2. Deficient sumoylation of yeast 2-micron plasmid proteins Rep1 and Rep2 associated with their loss from the plasmid-partitioning locus and impaired plasmid inheritance. Pinder JB, et al. PLoS One, 2013. PMID 23555963, Free PMC Article
    3. Improved identification of SUMO attachment sites using C-terminal SUMO mutants and tailored protease digestion strategies. Wohlschlegel JA, et al. J Proteome Res, 2006 Apr. PMID 16602682, Free PMC Article
    4. High-affinity single-domain binding proteins with a binary-code interface. Koide A, et al. Proc Natl Acad Sci U S A, 2007 Apr 17. PMID 17420456, Free PMC Article
    5. A high throughput mutagenic analysis of yeast sumo structure and function. Newman HA, et al. PLoS Genet, 2017 Feb. PMID 28166236, Free PMC Article

    See all (204) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the library of Smt3 mutants represents a valuable resource for further exploring the functions of sumoylation in cellular stress response and other SUMO-dependent pathways.
      Title: A high throughput mutagenic analysis of yeast sumo structure and function.
    2. Ulp2 controls the dynamic range of SUMO chain lengths by trimming them from the distal ends
      Title: In Vitro Studies Reveal a Sequential Mode of Chain Processing by the Yeast SUMO (Small Ubiquitin-related Modifier)-specific Protease Ulp2.
    3. Cdk1 and SUMO (Smt3) regulate Swe1 stability
      Title: Cdk1 and SUMO regulate Swe1 stability.
    4. the Zn(2+) motif of E1 has a role in SUMO adenylation
      Title: Role of the Zn(2+) motif of E1 in SUMO adenylation.
    5. A model is proposed for the positive control of the centromeric pool of Top2p, required for high minichromosome segregation fidelity, by Smt3p modification.
      Title: SIZ1/SIZ2 control of chromosome transmission fidelity is mediated by the sumoylation of topoisomerase II.
    6. there are a broad array of cellular processes regulated by SUMO conjugation
      Title: Defining the SUMO-modified proteome by multiple approaches in Saccharomyces cerevisiae.
    7. analysis of a SUMO-binding-motif mimic bound to Smt3p-Ubc9p
      Title: Structure of a SUMO-binding-motif mimic bound to Smt3p-Ubc9p: conservation of a non-covalent ubiquitin-like protein-E2 complex as a platform for selective interactions within a SUMO pathway.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tag activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ubiquitin-like protein ligase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein sumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein sumoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in septin ring IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    SUMO family protein SMT3
    NP_010798.1
    • Ubiquitin-like protein of the SUMO family; conjugated to lysine residues of target proteins; associates with transcriptionally active genes; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; human homolog SUMO1 can complement yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      1469400..1469705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180818.1 → NP_010798.1  TPA: SUMO family protein SMT3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010798.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTD1, Q12306
      UniProtKB/TrEMBL
      A6ZZ98, B3LFF9, C7GKU4, C8Z666, G2WBN7, N1P5U8
      Conserved Domains (1) summary
      COG5227
      Location:1 → 101
      SMT3; Ubiquitin-like protein (sentrin) [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12306.1

    Gene LinkOut

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