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    PER1 Per1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850411, updated on 3-Nov-2024

    Summary

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    Official Symbol
    PER1
    Official Full Name
    Per1p
    Primary source
    SGD:S000000640
    Locus tag
    YCR044C
    See related
    AllianceGenome:SGD:S000000640; FungiDB:YCR044C; VEuPathDB:YCR044C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    COS16
    Summary
    Predicted to enable hydrolase activity, acting on ester bonds. Involved in GPI anchor biosynthetic process and intracellular manganese ion homeostasis. Located in endoplasmic reticulum and fungal-type vacuole membrane. Human ortholog(s) of this gene implicated in hyperphosphatasia with impaired intellectual development syndrome 4. Orthologous to human PGAP3 (post-GPI attachment to proteins phospholipase 3). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See PER1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (206877..207950, complement)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene Rrt12p Neighboring gene mitochondrial 54S ribosomal protein IMG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Haploinsufficiency and the sex chromosomes from yeasts to humans. de Clare M, et al. BMC Biol, 2011 Feb 28. PMID 21356089, Free PMC Article
    2. PER1 is required for GPI-phospholipase A2 activity and involved in lipid remodeling of GPI-anchored proteins. Fujita M, et al. Mol Biol Cell, 2006 Dec. PMID 17021251, Free PMC Article
    3. Determination and physiological roles of the glycosylphosphatidylinositol lipid remodelling pathway in yeast. Yoko-O T, et al. Mol Microbiol, 2013 Apr. PMID 23421703
    4. Cdc1p is an endoplasmic reticulum-localized putative lipid phosphatase that affects Golgi inheritance and actin polarization by activating Ca2+ signaling. Losev E, et al. Mol Cell Biol, 2008 May. PMID 18332110, Free PMC Article
    5. The natural anticancer agent cantharidin alters GPI-anchored protein sorting by targeting Cdc1-mediated remodeling in endoplasmic reticulum. Sahu PK, et al. J Biol Chem, 2019 Mar 15. PMID 30659098, Free PMC Article

    See all (57) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydrolase activity, acting on ester bonds IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in GPI anchor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in GPI anchor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in GPI anchor biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular manganese ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type vacuole membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Per1p
    NP_009973.1
    • Protein of the endoplasmic reticulum; required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      206877..207950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178758.1 → NP_009973.1  TPA: Per1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009973.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VR53, P25625
      UniProtKB/TrEMBL
      A6ZTM5, B3LUA9, C8Z4D4, G2WA61, N1P6B9
      Conserved Domains (1) summary
      COG5237
      Location:1 → 357
      PER1; Predicted membrane protein [Function unknown]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25625.1

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