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    RERG RAS like estrogen regulated growth inhibitor [ Homo sapiens (human) ]

    Gene ID: 85004, updated on 28-Oct-2024

    Summary

    Official Symbol
    RERGprovided by HGNC
    Official Full Name
    RAS like estrogen regulated growth inhibitorprovided by HGNC
    Primary source
    HGNC:HGNC:15980
    See related
    Ensembl:ENSG00000134533 MIM:612664; AllianceGenome:HGNC:15980
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    RERG, a member of the RAS superfamily of GTPases, inhibits cell proliferation and tumor formation (Finlin et al., 2001 [PubMed 11533059]).[supplied by OMIM, Mar 2009]
    Expression
    Broad expression in endometrium (RPKM 41.3), adrenal (RPKM 21.0) and 16 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RERG in Genome Data Viewer
    Location:
    12p12.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (15107783..15221417, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (14985067..15098688, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (15260717..15374351, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6065 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4277 Neighboring gene long intergenic non-protein coding RNA 1489 Neighboring gene phosphodiesterase 6H Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:15191267-15191767 Neighboring gene RERG intronic transcript 1 Neighboring gene uncharacterized LOC124902887 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:15332809-15332980 Neighboring gene RERG antisense RNA 1 Neighboring gene uncharacterized LOC124902886 Neighboring gene uncharacterized LOC105369673 Neighboring gene methyltransferase like 8 pseudogene 1 Neighboring gene protein tyrosine phosphatase receptor type O

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC15754

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nuclear estrogen receptor binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    ras-related and estrogen-regulated growth inhibitor
    NP_001177655.1
    NP_116307.1
    XP_047285753.1
    XP_047285754.1
    XP_054229660.1
    XP_054229661.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001190726.2NP_001177655.1  ras-related and estrogen-regulated growth inhibitor isoform 2

      See identical proteins and their annotated locations for NP_001177655.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AK295343, BC007997
      Consensus CDS
      CCDS53753.1
      UniProtKB/Swiss-Prot
      Q96A58
      Related
      ENSP00000444485.1, ENST00000546331.5
      Conserved Domains (1) summary
      cl38936
      Location:8150
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
    2. NM_032918.3NP_116307.1  ras-related and estrogen-regulated growth inhibitor isoform 1

      See identical proteins and their annotated locations for NP_116307.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      BC007997, DC331754
      Consensus CDS
      CCDS8673.1
      UniProtKB/Swiss-Prot
      B2R9R0, B4DI02, Q96A58
      Related
      ENSP00000256953.2, ENST00000256953.6
      Conserved Domains (1) summary
      cd04146
      Location:8169
      RERG_RasL11_like; Ras-related and Estrogen-Regulated Growth inhibitor (RERG) and Ras-like 11 (RasL11)-like families

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      15107783..15221417 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429797.1XP_047285753.1  ras-related and estrogen-regulated growth inhibitor isoform X1

    2. XM_047429798.1XP_047285754.1  ras-related and estrogen-regulated growth inhibitor isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      14985067..15098688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054373685.1XP_054229660.1  ras-related and estrogen-regulated growth inhibitor isoform X1

    2. XM_054373686.1XP_054229661.1  ras-related and estrogen-regulated growth inhibitor isoform X2