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    ADGRE3 adhesion G protein-coupled receptor E3 [ Homo sapiens (human) ]

    Gene ID: 84658, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ADGRE3provided by HGNC
    Official Full Name
    adhesion G protein-coupled receptor E3provided by HGNC
    Primary source
    HGNC:HGNC:23647
    See related
    Ensembl:ENSG00000131355 MIM:606101; AllianceGenome:HGNC:23647
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EMR3
    Summary
    This gene encodes a member of the class B seven-span transmembrane (TM7) receptor family expressed predominantly by cells of the immune system. Family members are characterized by an extended extracellular region with a variable number of N-terminal epidermal growth factor (EGF)-like domains coupled to a TM7 domain via a mucin-like spacer domain. This gene is closely linked to the gene encoding egf-like molecule containing mucin-like hormone receptor 2 on chromosome 19. This protein may play a role in myeloid-myeloid interactions during immune and inflammatory responses. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
    Expression
    Biased expression in appendix (RPKM 3.7), spleen (RPKM 2.5) and 12 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ADGRE3 in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (14600117..14674844, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (14728189..14801146, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (14729929..14785656, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14176 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14177 Neighboring gene RNA, 7SL, cytoplasmic 337, pseudogene Neighboring gene C-type lectin domain containing 17A Neighboring gene RNA, 7SL, cytoplasmic 842, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14178 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10261 Neighboring gene small nucleolar RNA, H/ACA box 104 Neighboring gene integrin subunit beta 1 pseudogene 1 Neighboring gene YPEL5 pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10262 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10263 Neighboring gene zinc finger protein 333 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr19:14841378-14842577 Neighboring gene adhesion G protein-coupled receptor E2 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14869525-14870048 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:14870049-14870574 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:14884311-14884812 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14179 Neighboring gene CRISPRi-validated cis-regulatory element chr19.2424 Neighboring gene TMEM167A pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. [Peripheral blood EMR3 gene methylation level is correlated with breast cancer in Chinese women]. Zhou X, et al. Nan Fang Yi Ke Da Xue Xue Bao, 2021 Oct 20. PMID 34755660, Free PMC Article
    2. EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target. Kane AJ, et al. Neuroreport, 2010 Nov 17. PMID 20827226, Free PMC Article
    3. The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes. Matmati M, et al. J Leukoc Biol, 2007 Feb. PMID 17108056
    4. Human epidermal growth factor (EGF) module-containing mucin-like hormone receptor 3 is a new member of the EGF-TM7 family that recognizes a ligand on human macrophages and activated neutrophils. Stacey M, et al. J Biol Chem, 2001 Jun 1. PMID 11279179
    5. Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis. Plager DA, et al. PLoS One, 2010 Jul 6. PMID 20625511, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. [Peripheral blood EMR3 gene methylation level is correlated with breast cancer in Chinese women].
      Title: [Peripheral blood EMR3 gene methylation level is correlated with breast cancer in Chinese women].
    2. Given the poor survival associated with high levels of EMR-3 expression in glioma patients, impetus is provided to explore EMR-3 as a potential therapeutic target.
      Title: EMR-3: a potential mediator of invasive phenotypic variation in glioblastoma and novel therapeutic target.
    3. Additional transcription changes likely associated with Th2-like eosinophilic inflammation were prominent and included increased EMR1&3.
      Title: Gene transcription changes in asthmatic chronic rhinosinusitis with nasal polyps and comparison to those in atopic dermatitis.
    4. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    5. The expression of EGF-TM7 receptors on myeloid cells is differentially regulated. EMR3 is the first family member found mainly on granulocytes.
      Title: The human EGF-TM7 receptor EMR3 is a marker for mature granulocytes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of egf-like module containing, mucin-like, hormone receptor-like 3 (EMR3) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell surface receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ficolin-1-rich granule membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in membrane TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in secretory granule membrane TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    adhesion G protein-coupled receptor E3
    Names
    EGF-like module receptor 3
    EGF-like module-containing mucin-like hormone receptor-like 3
    egf-like module containing, mucin-like, hormone receptor-like 3
    egf-like module-containing mucin-like receptor 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289158.2 → NP_001276087.1  adhesion G protein-coupled receptor E3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001276087.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AF239764, AK298653, AL832663, AY358817, BC128053
      Consensus CDS
      CCDS74297.1
      UniProtKB/TrEMBL
      A8K4E4
      Related
      ENSP00000340758.4, ENST00000344373.8
      Conserved Domains (2) summary
      pfam01825
      Location:252 → 292
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:301 → 542
      7tm_4; Olfactory receptor

    2. NM_001289159.2 → NP_001276088.1  adhesion G protein-coupled receptor E3 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks three alternate in-frame exons in the 5' coding region, compared to variant 1. This results in a shorter isoform (3), compared to isoform 1.
      Source sequence(s)
      AF239764, AK298653, BC128053
      Consensus CDS
      CCDS74296.1
      UniProtKB/TrEMBL
      B7Z5A1, E7EW83
      Related
      ENSP00000396208.2, ENST00000443157.6
      Conserved Domains (2) summary
      pfam01825
      Location:178 → 218
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:227 → 468
      7tm_4; Olfactory receptor

    3. NM_032571.5 → NP_115960.2  adhesion G protein-coupled receptor E3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_115960.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AF239764, AK298653, AL832663, BC121130, BC128053
      Consensus CDS
      CCDS12315.1
      UniProtKB/Swiss-Prot
      Q9BY15
      UniProtKB/TrEMBL
      A8K4E4
      Related
      ENSP00000253673.4, ENST00000253673.6
      Conserved Domains (3) summary
      cd00054
      Location:67 → 104
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01825
      Location:304 → 344
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:353 → 594
      7tm_4; Olfactory receptor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      14600117..14674844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011528374.3 → XP_011526676.1  adhesion G protein-coupled receptor E3 isoform X1

      UniProtKB/TrEMBL
      A8K4E4
      Conserved Domains (3) summary
      cd00054
      Location:50 → 87
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam01825
      Location:287 → 327
      GPS; GPCR proteolysis site, GPS, motif
      cl21561
      Location:336 → 577
      7tm_4; Olfactory receptor

    2. XM_047439546.1 → XP_047295502.1  adhesion G protein-coupled receptor E3 isoform X2

    RNA

    1. XR_001753772.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      14728189..14801146 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054322398.1 → XP_054178373.1  adhesion G protein-coupled receptor E3 isoform X1

    2. XM_054322399.1 → XP_054178374.1  adhesion G protein-coupled receptor E3 isoform X2

    RNA

    1. XR_008485210.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_152939.1: Suppressed sequence

      Description
      NM_152939.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BY15.2 GenPept UniProtKB/Swiss-Prot:Q9BY15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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