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    CLPP3 CLP protease proteolytic subunit 3 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 842985, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CLPP3
    Official Full Name
    CLP protease proteolytic subunit 3
    Primary source
    TAIR:AT1G66670
    Locus tag
    AT1G66670
    See related
    Araport:AT1G66670
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    CLP protease proteolytic subunit 3; F4N21.19; F4N21_19; NCLPP3
    Summary
    One of several nuclear-encoded ClpPs (caseinolytic protease). Contains a highly conserved catalytic triad of Ser-type proteases (Ser-His-Asp). The name reflects nomenclature described in Adam et. al (2001).
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    Genomic context

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    See CLPP3 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (24863734..24865848, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Protein with RING/U-box and TRAF-like domain Neighboring gene Protein with RING/U-box and TRAF-like domain Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The E3 ligase AtCHIP positively regulates Clp proteolytic subunit homeostasis. Wei J, et al. J Exp Bot, 2015 Sep. PMID 26085677
    2. Modified Clp protease complex in the ClpP3 null mutant and consequences for chloroplast development and function in Arabidopsis. Kim J, et al. Plant Physiol, 2013 May. PMID 23548781, Free PMC Article
    3. Subunit stoichiometry, evolution, and functional implications of an asymmetric plant plastid ClpP/R protease complex in Arabidopsis. Olinares PD, et al. Plant Cell, 2011 Jun. PMID 21712416, Free PMC Article
    4. Identification of a 350-kDa ClpP protease complex with 10 different Clp isoforms in chloroplasts of Arabidopsis thaliana. Peltier JB, et al. J Biol Chem, 2001 May 11. PMID 11278690
    5. Structures, Functions, and Interactions of ClpT1 and ClpT2 in the Clp Protease System of Arabidopsis Chloroplasts. Kim J, et al. Plant Cell, 2015 May. PMID 25921872, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Comparison of the proteomics phenotype of clpp3-1 with the clpr2-1 and clpr4-1 phenotypes indicated very similar metabolic and protein homeostasis defects for these Clp core mutants.
      Title: Modified Clp protease complex in the ClpP3 null mutant and consequences for chloroplast development and function in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_105338.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ATP-dependent peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast thylakoid IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of chloroplastic endopeptidase Clp complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plastid stroma IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    CLP protease proteolytic subunit 3
    NP_564880.1
    • CLP protease proteolytic subunit 3 (CLPP3); FUNCTIONS IN: serine-type endopeptidase activity; INVOLVED IN: proteolysis; LOCATED IN: in 6 components; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase S14, ClpP, active site (InterPro:IPR018215), Peptidase S14, ClpP (InterPro:IPR001907); BEST Arabidopsis thaliana protein match is: CLP protease P4 (TAIR:AT5G45390.1); Has 13369 Blast hits to 13367 proteins in 2989 species: Archae - 6; Bacteria - 8381; Metazoa - 147; Fungi - 79; Plants - 1070; Viruses - 92; Other Eukaryotes - 3594 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      24863734..24865848 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_105338.4 → NP_564880.1  CLP protease proteolytic subunit 3 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564880.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O82421, Q94JY6, Q9SXJ6
      UniProtKB/TrEMBL
      A0A178WG76, A0A5S9WSB7
      Conserved Domains (1) summary
      pfam00574
      Location:85 → 257
      CLP_protease; Clp protease
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SXJ6.1

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