MYC2 Basic helix-loop-helix (bHLH) DNA-binding family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MYC2
Official Full Name: Basic helix-loop-helix (bHLH) DNA-binding family protein
Primary source: TAIR:AT1G32640
Locus tag: AT1G32640
See related: Araport:AT1G32640
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATMYC2; F6N18.4; F6N18_4; JAI1; JASMONATE INSENSITIVE 1; JIN1; RD22BP1; ZBF1
Summary: Encodes a MYC-related transcriptional activator with a typical DNA binding domain of a basic helix-loop-helix leucine zipper motif. Binds to an extended G-Box promoter motif and interacts with Jasmonate ZIM-domain proteins. Its transcription is induced by dehydration stress and ABA treatment. Negative regulator of blue light#Aeimediated photomorphogenic growth and blue and far-red-light#Aeiregulated gene expression. Positive regulator of lateral root formation. Regulates diverse JA-dependent functions. Negatively regulates Trp metabolism and biosynthesis of Trp-derived secondary metabolites. Positively regulates flavonoid biosynthesis, resistance to insects, and response to oxidative stress. Regulates other transcription factors, and negatively regulates its own expression.
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Genomic context

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See MYC2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 1

Sequence:: Chromosome: 1; NC_003070.9 (11798119..11801407, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis thaliana MYC2 and MYC3 Are Involved in Ethylene-Regulated Hypocotyl Growth as Negative Regulators.
Title: Arabidopsis thaliana MYC2 and MYC3 Are Involved in Ethylene-Regulated Hypocotyl Growth as Negative Regulators.
PHOSPHATE STARVATION RESPONSE1 (PHR1) interacts with JASMONATE ZIM-DOMAIN (JAZ) and MYC2 to modulate phosphate deficiency-induced jasmonate signaling in Arabidopsis.
Title: PHOSPHATE STARVATION RESPONSE1 (PHR1) interacts with JASMONATE ZIM-DOMAIN (JAZ) and MYC2 to modulate phosphate deficiency-induced jasmonate signaling in Arabidopsis.
CK2 promotes jasmonic acid signaling response by phosphorylating MYC2 in Arabidopsis.
Title: CK2 promotes jasmonic acid signaling response by phosphorylating MYC2 in Arabidopsis.
MYC2 influences salicylic acid biosynthesis and defense against bacterial pathogens in Arabidopsis thaliana.
Title: MYC2 influences salicylic acid biosynthesis and defense against bacterial pathogens in Arabidopsis thaliana.
MYB21 interacts with MYC2 to control the expression of terpene synthase genes in flowers of Freesia hybrida and Arabidopsis thaliana.
Title: MYB21 interacts with MYC2 to control the expression of terpene synthase genes in flowers of Freesia hybrida and Arabidopsis thaliana.
A bHLH transcription factor, MYC2, imparts salt intolerance by regulating proline biosynthesis in Arabidopsis.
Title: A bHLH transcription factor, MYC2, imparts salt intolerance by regulating proline biosynthesis in Arabidopsis.
MYC2, MYC3, and MYC4 function additively in wounding-induced jasmonic acid biosynthesis and catabolism.
Title: MYC2, MYC3, and MYC4 function additively in wounding-induced jasmonic acid biosynthesis and catabolism.
Jasmonic acid promotes leaf senescence through MYC2-mediated repression of CATALASE2 expression in Arabidopsis.
Title: Jasmonic acid promotes leaf senescence through MYC2-mediated repression of CATALASE2 expression in Arabidopsis.
The JA-pathway MYC transcription factors regulate photomorphogenic responses by targeting HY5 gene expression.
Title: The JA-pathway MYC transcription factors regulate photomorphogenic responses by targeting HY5 gene expression.
Integrated multi-omics framework of the plant response to jasmonic acid.
Title: Integrated multi-omics framework of the plant response to jasmonic acid.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_102998.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription cis-regulatory region binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within extracellular ATP signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_negative_effect indole glucosinolate biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_negative_effect indole glucosinolate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within jasmonic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of flavonoid biosynthetic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein homotetramerization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of defense response to insect	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of secondary cell wall biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of tryptophan metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to desiccation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to jasmonic acid	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to wounding	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to wounding	TAS Traceable Author Statement more info	PubMed
involved_in root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal complex development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_negative_effect tryptophan metabolic process	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Basic helix-loop-helix (bHLH) DNA-binding family protein

NP_174541.1

MYC2; FUNCTIONS IN: DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: in 13 processes; LOCATED IN: nucleus; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092), Helix-loop-helix DNA-binding (InterPro:IPR011598); BEST Arabidopsis thaliana protein match is: Basic helix-loop-helix (bHLH) DNA-binding family protein (TAIR:AT4G17880.1); Has 4078 Blast hits to 3762 proteins in 672 species: Archae - 2; Bacteria - 2; Metazoa - 761; Fungi - 108; Plants - 3150; Viruses - 25; Other Eukaryotes - 30 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

11798119..11801407 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_102998.4 → NP_174541.1 Basic helix-loop-helix (bHLH) DNA-binding family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_174541.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O48644, Q39204, Q5K1L7, Q8W2F4, Q9LPJ8

UniProtKB/TrEMBL

A0A178W7C3, A0A5S9WL92

Conserved Domains (2) summary

cd11449
Location:445 → 521

bHLH_AtAIB_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein ABA-INDUCIBLE bHLH-TYPE (AIB) and similar proteins

pfam14215
Location:68 → 252

bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal