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    CSN5A COP9 signalosome 5A [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838899, updated on 18-Sep-2024

    Summary

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    Official Symbol
    CSN5A
    Official Full Name
    COP9 signalosome 5A
    Primary source
    TAIR:AT1G22920
    Locus tag
    AT1G22920
    See related
    Araport:AT1G22920
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AJH1; ARABIDOPSIS JAB1 HOMOLOG 1; COP9 signalosome 5A; CSN5; F19G10.12; F19G10_12; JAB1; PUTATIVE JUN KINASE ACTIVATOR
    Summary
    AJH1 encodes a protein similar to JAB1, a specific mammalian coactivator of AP-1 transcription. Encodes a subunit of the COP9 complex that is involved in protein deneddylation. Plants with mutations in CSN5A and CSN5B have a de-etiolated phenotype.
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    Genomic context

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    See CSN5A in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    6
    Sequence:
    Chromosome: 1; NC_003070.9 (8109574..8112061, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Disease resistance-responsive (dirigent-like protein) family protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene T-complex protein 11 Neighboring gene thiamine biosynthesis protein Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. COP9 signalosome subunit 5A affects phenylpropanoid metabolism, trichome formation and transcription of key genes of a regulatory tri-protein complex in Arabidopsis. Wei S, et al. BMC Plant Biol, 2018 Jun 25. PMID 29940863, Free PMC Article
    2. Instability of the Arabidopsis mutant csn5a-2 caused by epigenetic modification of intronic T-DNA. Jia X, et al. Plant Sci, 2015 Sep. PMID 26259174
    3. Loss of the CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome subunit 5 is sufficient to cause the cop/det/fus mutant phenotype in Arabidopsis. Dohmann EM, et al. Plant Cell, 2005 Jul. PMID 15923347, Free PMC Article
    4. Pathogen and circadian controlled 1 (PCC1) protein is anchored to the plasma membrane and interacts with subunit 5 of COP9 signalosome in Arabidopsis. Mir R, et al. PLoS One, 2014. PMID 24475254, Free PMC Article
    5. Arabidopsis homologs of a c-Jun coactivator are present both in monomeric form and in the COP9 complex, and their abundance is differentially affected by the pleiotropic cop/det/fus mutations. Kwok SF, et al. Plant Cell, 1998 Nov. PMID 9811788, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. affects trichome production and the metabolism of a wide range of phenylpropanoid and carotenoid compounds
      Title: COP9 signalosome subunit 5A affects phenylpropanoid metabolism, trichome formation and transcription of key genes of a regulatory tri-protein complex in Arabidopsis.
    2. These findings indicate that the rescue of csn5a-2 resulted from a trans T-DNA-mediated epigenetic effect on the csn5a-2 intronic T-DNA.
      Title: Instability of the Arabidopsis mutant csn5a-2 caused by epigenetic modification of intronic T-DNA.
    3. The organization of a CSN5-containing subcomplex of the COP9 signalosome.
      Title: The organization of a CSN5-containing subcomplex of the COP9 signalosome.
    4. Data suggest that Arabidopsis csn mutants undergo DNA damage, which might be the cause of the delay in G2 cell cycle progression.
      Title: The Arabidopsis COP9 signalosome is essential for G2 phase progression and genomic stability.
    5. unequal role that CSN(CSN5A) and CSN(CSN5B) play in controlling the cellular derubylation of cullins
      Title: The Arabidopsis CSN5A and CSN5B subunits are present in distinct COP9 signalosome complexes, and mutations in their JAMM domains exhibit differential dominant negative effects on development.
    6. Results indicate that although CSN6A and CSN6B retain mostly redundant functions, CSN5A and CSN5B play unequal roles in the regulation of plant development.
      Title: Role of the MPN subunits in COP9 signalosome assembly and activity, and their regulatory interaction with Arabidopsis Cullin3-based E3 ligases.
    7. The cop/det/fus mutant phenotype may be the result of the defects caused by impaired CSN5-dependent deneddylation of cullin-containing E3s.
      Title: Loss of the CONSTITUTIVE PHOTOMORPHOGENIC9 signalosome subunit 5 is sufficient to cause the cop/det/fus mutant phenotype in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102139.2
    NM_202161.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within COP9 signalosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of photomorphogenesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within photomorphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deneddylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of defense response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within specification of floral organ identity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COP9 signalosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    COP9 signalosome 5A
    NP_173705.1
    • COP9 signalosome 5A (CSN5A); CONTAINS InterPro DOMAIN/s: Mov34/MPN/PAD-1 (InterPro:IPR000555); BEST Arabidopsis thaliana protein match is: COP9-signalosome 5B (TAIR:AT1G71230.1); Has 1314 Blast hits to 1313 proteins in 252 species: Archae - 0; Bacteria - 4; Metazoa - 460; Fungi - 400; Plants - 277; Viruses - 0; Other Eukaryotes - 173 (source: NCBI BLink).
    NP_973890.1
    • COP9 signalosome 5A (CSN5A); CONTAINS InterPro DOMAIN/s: Mov34/MPN/PAD-1 (InterPro:IPR000555); BEST Arabidopsis thaliana protein match is: COP9-signalosome 5B (TAIR:AT1G71230.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8109574..8112061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_102139.2 → NP_173705.1  COP9 signalosome 5A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173705.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A1A6G7, F4I325, O23130, O82524, Q84WE7, Q8LAZ7
      UniProtKB/TrEMBL
      A0A178W4F3, A0A5S9VMT5
      Conserved Domains (1) summary
      cd08069
      Location:48 → 321
      MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5

    2. NM_202161.1 → NP_973890.1  COP9 signalosome 5A [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973890.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LAZ7
      Conserved Domains (1) summary
      cd08069
      Location:48 → 321
      MPN_RPN11_CSN5; Mov34/MPN/PAD-1 family: proteasomal regulatory protein Rpn11 and signalosome complex subunit CSN5
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8LAZ7.2

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