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    BES1 Brassinosteroid signaling positive regulator (BZR1) family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838518, updated on 8-Oct-2024

    Summary

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    Official Symbol
    BES1
    Official Full Name
    Brassinosteroid signaling positive regulator (BZR1) family protein
    Primary source
    TAIR:AT1G19350
    Locus tag
    AT1G19350
    See related
    Araport:AT1G19350
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    107 PROTEIN; BRASSINAZOLE-RESISTANT 2; BRI1-EMS-SUPPRESSOR 1; BZR2; F18O14.7; F18O14_7
    Summary
    Encodes brassinosteroid (BR) signalling protein that accumulates in the nucleus as dephosphorylated form in response to BRs. Is phosphorylated by the BIN2 GSK3 kinase. It synergistically interacts with BIM1 to bind to E box sequences (CANNTG). The protein contains a nuclear localization signal (NLS), followed by a highly conserved amino-terminal domain (N) shared by all family members, a BIN2 phosphorylation domain (P), a PEST motif, involved in protein degradation in the absence of BR, and a carboxyl-terminal domain. BES1 can interact with the ELF6 and REF6 Jumonji N/C-domain containing proteins and may direct them to modify histone methylation upstream of some brassinosteroid responsive-genes. Works with BRAVO to regulate QC division in the root.
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    Genomic context

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    See BES1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    4
    Sequence:
    Chromosome: 1; NC_003070.9 (6688463..6691216)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene histone deacetylase complex subunit Neighboring gene Methyltransferase MT-A70 family protein Neighboring gene Nucleotide-diphospho-sugar transferase family protein Neighboring gene uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Wheat Type One Protein Phosphatase Participates in the Brassinosteroid Control of Root Growth via Activation of BES1. Bradai M, et al. Int J Mol Sci, 2021 Sep 27. PMID 34638765, Free PMC Article
    2. A brassinosteroid transcriptional network revealed by genome-wide identification of BESI target genes in Arabidopsis thaliana. Yu X, et al. Plant J, 2011 Feb. PMID 21214652
    3. SINAT E3 Ligases Control the Light-Mediated Stability of the Brassinosteroid-Activated Transcription Factor BES1 in Arabidopsis. Yang M, et al. Dev Cell, 2017 Apr 10. PMID 28399399, Free PMC Article
    4. Regulation of Shoot Branching by Strigolactones and Brassinosteroids: Conserved and Specific Functions of Arabidopsis BES1 and Rice BZR1. Hu J, et al. Mol Plant, 2020 Jun 1. PMID 32222484
    5. Brassinosteroid-Activated BRI1-EMS-SUPPRESSOR 1 Inhibits Flavonoid Biosynthesis and Coordinates Growth and UV-B Stress Responses in Plants. Liang T, et al. Plant Cell, 2020 Oct. PMID 32796123, Free PMC Article

    See all (61) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RACK1 links phyB and BES1 to coordinate brassinosteroid-dependent root meristem development.
      Title: RACK1 links phyB and BES1 to coordinate brassinosteroid-dependent root meristem development.
    2. Brassinosteroid regulates stomatal development in etiolated Arabidopsis cotyledons via transcription factors BZR1 and BES1.
      Title: Brassinosteroid regulates stomatal development in etiolated Arabidopsis cotyledons via transcription factors BZR1 and BES1.
    3. Comparative analysis of BZR1/BES1 family transcription factors in Arabidopsis.
      Title: Comparative analysis of BZR1/BES1 family transcription factors in Arabidopsis.
    4. A conserved brassinosteroid-mediated BES1-CERP-EXPA3 signaling cascade controls plant cell elongation.
      Title: A conserved brassinosteroid-mediated BES1-CERP-EXPA3 signaling cascade controls plant cell elongation.
    5. Brassinosteroid transcription factor BES1 modulates nitrate deficiency by promoting NRT2.1 and NRT2.2 transcription in Arabidopsis.
      Title: Brassinosteroid transcription factor BES1 modulates nitrate deficiency by promoting NRT2.1 and NRT2.2 transcription in Arabidopsis.
    6. Reciprocal inhibition of expression between RAV1 and BES1 modulates plant growth and development in Arabidopsis.
      Title: Reciprocal inhibition of expression between RAV1 and BES1 modulates plant growth and development in Arabidopsis.
    7. Transcriptome Analysis Points to BES1 as a Transducer of Strigolactone Effects on Drought Memory in Arabidopsis thaliana.
      Title: Transcriptome Analysis Points to BES1 as a Transducer of Strigolactone Effects on Drought Memory in Arabidopsis thaliana.
    8. Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants.
      Title: Transcription factor BES1 interacts with HSFA1 to promote heat stress resistance of plants.
    9. The F-box E3 ubiquitin ligase BAF1 mediates the degradation of the brassinosteroid-activated transcription factor BES1 through selective autophagy in Arabidopsis.
      Title: The F-box E3 ubiquitin ligase BAF1 mediates the degradation of the brassinosteroid-activated transcription factor BES1 through selective autophagy in Arabidopsis.
    10. Wheat Type One Protein Phosphatase Participates in the Brassinosteroid Control of Root Growth via Activation of BES1.
      Title: Wheat Type One Protein Phosphatase Participates in the Brassinosteroid Control of Root Growth via Activation of BES1.
    Submit: New GeneRIF Correction See all GeneRIFs (41)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    NM_001084093.1
    NM_101792.4
    NM_202134.1
    NM_202135.3
    NM_202136.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within UV protection IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within brassinosteroid mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in brassinosteroid mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to brassinosteroid stimulus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in quiescent center organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Brassinosteroid signaling positive regulator (BZR1) family protein
    NP_001077562.1
    • BRI1-EMS-SUPPRESSOR 1 (BES1); CONTAINS InterPro DOMAIN/s: BZR1, transcriptional repressor (InterPro:IPR008540); BEST Arabidopsis thaliana protein match is: Brassinosteroid signalling positive regulator (BZR1) family protein (TAIR:AT1G75080.2); Has 2916 Blast hits to 477 proteins in 80 species: Archae - 0; Bacteria - 14; Metazoa - 122; Fungi - 71; Plants - 275; Viruses - 0; Other Eukaryotes - 2434 (source: NCBI BLink).
    NP_564081.1
    • BRI1-EMS-SUPPRESSOR 1 (BES1); CONTAINS InterPro DOMAIN/s: BZR1, transcriptional repressor (InterPro:IPR008540); BEST Arabidopsis thaliana protein match is: Brassinosteroid signalling positive regulator (BZR1) family protein (TAIR:AT1G75080.2); Has 2916 Blast hits to 477 proteins in 80 species: Archae - 0; Bacteria - 14; Metazoa - 122; Fungi - 71; Plants - 275; Viruses - 0; Other Eukaryotes - 2434 (source: NCBI BLink).
    NP_973863.1
    • BRI1-EMS-SUPPRESSOR 1 (BES1); CONTAINS InterPro DOMAIN/s: BZR1, transcriptional repressor (InterPro:IPR008540); BEST Arabidopsis thaliana protein match is: Brassinosteroid signalling positive regulator (BZR1) family protein (TAIR:AT1G75080.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_973864.1
    • BRI1-EMS-SUPPRESSOR 1 (BES1); CONTAINS InterPro DOMAIN/s: BZR1, transcriptional repressor (InterPro:IPR008540); BEST Arabidopsis thaliana protein match is: Brassinosteroid signalling positive regulator (BZR1) family protein (TAIR:AT1G75080.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_973865.1
    • BRI1-EMS-SUPPRESSOR 1 (BES1); CONTAINS InterPro DOMAIN/s: BZR1, transcriptional repressor (InterPro:IPR008540); BEST Arabidopsis thaliana protein match is: Brassinosteroid signalling positive regulator (BZR1) family protein (TAIR:AT1G75080.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6688463..6691216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_202135.3 → NP_973864.1  Brassinosteroid signaling positive regulator (BZR1) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973864.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LCX8, Q94JU1, Q9LN63, Q9SEG5
      UniProtKB/TrEMBL
      A0A178W3G4, A0A5S9V6H0, A0A654ECR7
      Conserved Domains (1) summary
      pfam05687
      Location:21 → 128
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal

    2. NM_202134.1 → NP_973863.1  Brassinosteroid signaling positive regulator (BZR1) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973863.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W3G4, A0A5S9V6H0, F4HP45
      Conserved Domains (1) summary
      pfam05687
      Location:43 → 150
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal

    3. NM_202136.1 → NP_973865.1  Brassinosteroid signaling positive regulator (BZR1) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973865.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LCX8, Q94JU1, Q9LN63, Q9SEG5
      UniProtKB/TrEMBL
      A0A178W3G4, A0A5S9V6H0, A0A654ECR7
      Conserved Domains (1) summary
      pfam05687
      Location:21 → 128
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal

    4. NM_101792.4 → NP_564081.1  Brassinosteroid signaling positive regulator (BZR1) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564081.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LCX8, Q94JU1, Q9LN63, Q9SEG5
      UniProtKB/TrEMBL
      A0A178W3G4, A0A5S9V6H0, A0A654ECR7
      Conserved Domains (1) summary
      pfam05687
      Location:21 → 128
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal

    5. NM_001084093.1 → NP_001077562.1  Brassinosteroid signaling positive regulator (BZR1) family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001077562.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8LCX8, Q94JU1, Q9LN63, Q9SEG5
      UniProtKB/TrEMBL
      A0A178W3G4, A0A5S9V6H0, A0A654ECR7
      Conserved Domains (1) summary
      pfam05687
      Location:21 → 128
      BES1_N; BES1/BZR1 plant transcription factor, N-terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LN63.1

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