Nde1 nudE neurodevelopment protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Nde1provided by RGD
Full Name: nudE neurodevelopment protein 1provided by RGD
Primary source: RGD:620038
See related: EnsemblRapid:ENSRNOG00000058007 AllianceGenome:RGD:620038
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Nude
Summary: Enables protein domain specific binding activity. Predicted to be involved in several processes, including microtubule cytoskeleton organization; nervous system development; and vesicle transport along microtubule. Predicted to act upstream of or within forebrain development and neuroblast proliferation. Predicted to be located in spindle pole centrosome and synapse. Predicted to be part of kinesin complex. Predicted to be active in centrosome and kinetochore. Human ortholog(s) of this gene implicated in lissencephaly 4. Orthologous to human NDE1 (nudE neurodevelopment protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 143.9), Heart (RPKM 107.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q11

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (1347010..1391167, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (839788..883946, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (860513..904624, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the severity of NDE1-associated microcephaly results not from defects in mitosis, but rather the inability of neural progenitors to ever reach this stage
Title: Severe NDE1-mediated microcephaly results from neural progenitor cell cycle arrests at multiple specific stages.
Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin.
Title: Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin.
Together, these results indicate that DISC1 regulates the localization of NUDEL/LIS1/14-3-3epsilon complex into the axons as a cargo receptor for axon elongation.
Title: DISC1 regulates the transport of the NUDEL/LIS1/14-3-3epsilon complex through kinesin-1.

Submit: New GeneRIF Correction

General gene information

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Markers

AU049328 (e-PCR)
- UniSTS:145776

D0S2247 (e-PCR)
- UniSTS:148113

RH131713 (e-PCR)
- UniSTS:214996

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in centrosome duplication	IEA Inferred from Electronic Annotation more info
involved_in centrosome duplication	ISO Inferred from Sequence Orthology more info
involved_in centrosome duplication	ISS Inferred from Sequence or Structural Similarity more info
involved_in centrosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in cerebral cortex development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	ISO Inferred from Sequence Orthology more info
involved_in cerebral cortex development	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of chromosome localization	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of chromosome localization	IEA Inferred from Electronic Annotation more info
involved_in establishment of chromosome localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of mitotic spindle orientation	IBA Inferred from Biological aspect of Ancestor more info
involved_in establishment of mitotic spindle orientation	IEA Inferred from Electronic Annotation more info
involved_in establishment of mitotic spindle orientation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain development	ISO Inferred from Sequence Orthology more info
involved_in microtubule nucleation	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule nucleation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule nucleation	ISO Inferred from Sequence Orthology more info
involved_in microtubule organizing center organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic centrosome separation	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IEA Inferred from Electronic Annotation more info
involved_in neuroblast proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in neuron migration	IEA Inferred from Electronic Annotation more info
involved_in neuron migration	ISO Inferred from Sequence Orthology more info
involved_in vesicle transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle transport along microtubule	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in cleavage furrow	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in spindle	IEA Inferred from Electronic Annotation more info
located_in spindle	ISO Inferred from Sequence Orthology more info
located_in spindle pole centrosome	IEA Inferred from Electronic Annotation more info
located_in spindle pole centrosome	ISO Inferred from Sequence Orthology more info
located_in spindle pole centrosome	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: nuclear distribution protein nudE homolog 1

Names: LIS1-interacting protein NUDE1; nuclear distribution gene E homolog 1; nuclear distribution protein nudE homolog 1-like; nudE nuclear distribution E homolog 1; nudE nuclear distribution gene E homolog 1; rNudE

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053347.2 → NP_445799.1 nuclear distribution protein nudE homolog 1

See identical proteins and their annotated locations for NP_445799.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q642F3, Q9ES39

UniProtKB/TrEMBL

A0A8I6AC74, A6KU37

Related

ENSRNOP00000073786.3, ENSRNOT00000086392.3

Conserved Domains (2) summary

COG1196
Location:27 → 186

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam04880
Location:134 → 309

NUDE_C; NUDE protein, C-terminal conserved region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

1347010..1391167 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006245851.3 → XP_006245913.1 nuclear distribution protein nudE homolog 1 isoform X2

See identical proteins and their annotated locations for XP_006245913.1

UniProtKB/Swiss-Prot

Q642F3, Q9ES39

UniProtKB/TrEMBL

A0A8I6AC74, A6KU37

Conserved Domains (2) summary

COG1196
Location:27 → 186

Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

pfam04880
Location:134 → 309

NUDE_C; NUDE protein, C-terminal conserved region
XM_063269977.1 → XP_063126047.1 nuclear distribution protein nudE homolog 1 isoform X3
XM_006245849.5 → XP_006245911.1 nuclear distribution protein nudE homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006245911.1

UniProtKB/TrEMBL

A0A8I6AC74

Conserved Domains (3) summary

PRK14160
Location:1 → 185

PRK14160; heat shock protein GrpE; Provisional

pfam04880
Location:134 → 309

NUDE_C; NUDE protein, C-terminal conserved region

cl03075
Location:34 → 127

GrpE; nucleotide exchange factor GrpE
XM_006245850.5 → XP_006245912.1 nuclear distribution protein nudE homolog 1 isoform X1

See identical proteins and their annotated locations for XP_006245912.1

UniProtKB/TrEMBL

A0A8I6AC74

Conserved Domains (3) summary

PRK14160
Location:1 → 185

PRK14160; heat shock protein GrpE; Provisional

pfam04880
Location:134 → 309

NUDE_C; NUDE protein, C-terminal conserved region

cl03075
Location:34 → 127

GrpE; nucleotide exchange factor GrpE
XM_063269978.1 → XP_063126048.1 nuclear distribution protein nudE homolog 1 isoform X3