SAL1 SAL1 phosphatase-like protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: SAL1
Gene description: SAL1 phosphatase-like protein
Primary source: Araport:AT5G63980
Locus tag: AT5G63980
See related: TAIR:AT5G63980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ALTERED EXPRESSION OF APX2 8; ALX8; AtFRY1; ATSAL1; FIERY1; FRY1; HIGH EXPRESSION OF OSMOTICALLY RESPONSIVE GENES 2; HOS2; MBM17.8; MBM17_8; RON1; ROTUNDA 1; SUPO1; suppressors of PIN1 overexpression 1
Summary: Encodes a bifunctional protein that has 3'(2'),5'-bisphosphate nucleotidase and inositol polyphosphate 1-phosphatase activities and rescues sulfur assimilation mutants in yeast. It is involved in the response to cold, drought (negative regulator of drought tolerance), and ABA. Mutants in this gene exhibit enhanced induction of stress genes in response to cold, ABA, salt and dehydration due to higher accumulation of the second messenger, inositol (1,4,5)- triphosphate (IP(3)). Involved in degradation of small mRNAs. Mutants also affect the accumulation of miRNA target cleavage products. Regulates light-dependent repression of hypocotyl elongation and flowering time via its 3'(2'),5'-bisphosphate nucleotidase activity.
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Genomic context

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See SAL1 in Genome Data Viewer

Location:: chromosome: 5

Exon count:: 7

Sequence:: Chromosome: 5; NC_003076.8 (25610002..25611802)

Chromosome 5 - NC_003076.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003076.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A mutation in Arabidopsis SAL1 alters its in vitro activity against IP3 and delays developmental leaf senescence in association with lower ROS levels.
Title: A mutation in Arabidopsis SAL1 alters its in vitro activity against IP(3) and delays developmental leaf senescence in association with lower ROS levels.
PAP/SAL1 retrograde signaling pathway modulates iron deficiency response in alkaline soils.
Title: PAP/SAL1 retrograde signaling pathway modulates iron deficiency response in alkaline soils.
fiery1, hyl1 and se interact and require miRNA precursor processing in Arabidopsis
Title: Efficiency and precision of microRNA biogenesis modes in plants.
SAL1 expression affects RNA polymerase II termination.
Title: RNA Polymerase II Read-Through Promotes Expression of Neighboring Genes in SAL1-PAP-XRN Retrograde Signaling.
Data indicate that the redox regulation of 3'-phosphoadenosine 5'-phosphate (PAP) phosphatase SAL1 for activation of chloroplast signaling is conserved in the plant kingdom.
Title: Sensing and signaling of oxidative stress in chloroplasts by inactivation of the SAL1 phosphoadenosine phosphatase.
These results identified SAL1 as a new component mediating cadmium (Cd) toxicity and established the role of the endoplasmic reticulum stress response in Cd toxicity.
Title: A SAL1 Loss-of-Function Arabidopsis Mutant Exhibits Enhanced Cadmium Tolerance in Association with Alleviation of Endoplasmic Reticulum Stress.
this study revealed several new phenotypes caused by disruption of FIERY1, the decrease in glucosinolate content and in accumulation of sulfur and potassium.
Title: Effects of fou8/fry1 mutation on sulfur metabolism: is decreased internal sulfate the trigger of sulfate starvation response?
SAL1 regulates its levels by dephosphorylating 3'-phosphoadenosine 5'-phosphate and accumulates in chloroplasts and mitochondria but not in the cytosol
Title: Evidence for a SAL1-PAP chloroplast retrograde pathway that functions in drought and high light signaling in Arabidopsis.
The genetic interaction between HY5 and FRY1 indicates that HY5 and FRY1 may act in overlapping pathways that mediate light signaling and lateral root development.
Title: Genetic interaction of two abscisic acid signaling regulators, HY5 and FIERY1, in mediating lateral root formation.
RNA silencing modulated by FRY1 and XRN4 plays an important role in shaping root architecture.
Title: The bifunctional abiotic stress signalling regulator and endogenous RNA silencing suppressor FIERY1 is required for lateral root formation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_125794.5

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables 3'(2'),5'-bisphosphate nucleotidase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,4-bisphosphate 1-phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,4-bisphosphate 1-phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within detection of oxidative stress	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within miRNA catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within negative regulation of signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within phosphatidylinositol-mediated signaling	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of unidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulation of jasmonic acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to cation stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to freezing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to light stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to light stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sulfur compound metabolic process	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast	HDA more info	PubMed
located_in chloroplast	IDA Inferred from Direct Assay more info	PubMed
located_in chloroplast stroma	HDA more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in intracellular anatomical structure	TAS Traceable Author Statement more info	PubMed
colocalizes_with mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: SAL1 phosphatase-like protein

NP_201203.3

SAL1; FUNCTIONS IN: 3'(2'),5'-bisphosphate nucleotidase activity, nucleotide phosphatase activity, inositol or phosphatidylinositol phosphatase activity; INVOLVED IN: in 15 processes; LOCATED IN: nucleus, chloroplast, chloroplast stroma, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Inositol monophosphatase (InterPro:IPR000760), 3(2),5 -bisphosphate nucleotidase HAL2 (InterPro:IPR006239), Inositol monophosphatase, metal-binding site (InterPro:IPR020583); BEST Arabidopsis thaliana protein match is: Inositol monophosphatase family protein (TAIR:AT5G64000.1); Has 8292 Blast hits to 8290 proteins in 1695 species: Archae - 42; Bacteria - 5356; Metazoa - 208; Fungi - 241; Plants - 302; Viruses - 0; Other Eukaryotes - 2143 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003076.8 Reference assembly

Range

25610002..25611802

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_125794.5 → NP_201203.3 SAL1 phosphatase-like protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4KC73, Q0WTT5, Q42546

UniProtKB/TrEMBL

A0A5S9YGV0, A0A654GDT4