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    Pex3 peroxisomal biogenesis factor 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 83519, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Pex3provided by RGD
    Official Full Name
    peroxisomal biogenesis factor 3provided by RGD
    Primary source
    RGD:621636
    See related
    EnsemblRapid:ENSRNOG00000015660 AllianceGenome:RGD:621636
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable lipid binding activity and protein-macromolecule adaptor activity. Involved in peroxisome membrane biogenesis. Located in cytosol and peroxisomal membrane. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 10A. Orthologous to human PEX3 (peroxisomal biogenesis factor 3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 102.6), Heart (RPKM 92.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    1p13
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (9732641..9774479, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (7912508..7954474, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (7685209..7726238, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene phosphatase and actin regulator 2 Neighboring gene alpha-L-fucosidase 2 Neighboring gene adenosine deaminase, tRNA-specific 2 Neighboring gene uncharacterized LOC120098785

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Defective peroxisome membrane synthesis due to mutations in human PEX3 causes Zellweger syndrome, complementation group G. Muntau AC, et al. Am J Hum Genet, 2000 Oct. PMID 10958759, Free PMC Article
    2. The peroxin pex3p initiates membrane assembly in peroxisome biogenesis. Ghaedi K, et al. Mol Biol Cell, 2000 Jun. PMID 10848631, Free PMC Article
    3. Alkaline density gradient floatation of membranes: polypeptide composition of the mammalian peroxisomal membrane. Gouveia AM, et al. Anal Biochem, 1999 Oct 15. PMID 10527525
    4. Identification and characterization of the human peroxin PEX3. Soukupova M, et al. Eur J Cell Biol, 1999 Jun. PMID 10430017
    5. Cloning and characterization of the gene encoding the human peroxisomal assembly protein Pex3p. Kammerer S, et al. FEBS Lett, 1998 Jun 5. PMID 9657383

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in peroxisome membrane biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in peroxisome organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in peroxisome organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into peroxisome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein import into peroxisome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in peroxisomal membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisomal membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in peroxisomal membrane TAS
    Traceable Author Statement
    more info
    		  
    located_in peroxisome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-lipid complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-lipid complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    peroxisomal biogenesis factor 3
    Names
    peroxin-3
    peroxisomal assembly protein PEX3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031350.2 → NP_112640.1  peroxisomal biogenesis factor 3

      See identical proteins and their annotated locations for NP_112640.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q9JJK4
      UniProtKB/TrEMBL
      A0A8I6AUP3, A6JP61
      Conserved Domains (1) summary
      pfam04882
      Location:11 → 361
      Peroxin-3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      9732641..9774479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039092495.2 → XP_038948423.1  peroxisomal biogenesis factor 3 isoform X2

      UniProtKB/TrEMBL
      A0A8I6AUP3, A0A8L2QAW4
      Conserved Domains (1) summary
      pfam04882
      Location:11 → 359
      Peroxin-3

    2. XM_039092487.2 → XP_038948415.1  peroxisomal biogenesis factor 3 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AUP3
      Related
      ENSRNOP00000021524.4, ENSRNOT00000021524.6
      Conserved Domains (1) summary
      pfam04882
      Location:11 → 347
      Peroxin-3
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9JJK4.1 GenPept UniProtKB/Swiss-Prot:Q9JJK4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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