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    FAR4 fatty acid reductase 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 823579, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FAR4
    Official Full Name
    fatty acid reductase 4
    Primary source
    TAIR:AT3G44540
    Locus tag
    AT3G44540
    See related
    Araport:AT3G44540
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    fatty acid reductase 4
    Summary
    Encodes a member of the eight-member gene family encoding alcohol-forming fatty acyl-CoA reductases (FARs) identified in Arabidopsis thaliana. Three of the FARs, FAR1 (At5g22500), FAR4 (At3g44540) and FAR5 (At3g44550), are shown to generate the fatty alcohols found in root, seed coat, and wound-induced leaf tissue.
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    Genomic context

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    See FAR4 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    9
    Sequence:
    Chromosome: 3; NC_003074.8 (16123426..16128030)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene histone chaperone HIRA-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene fatty acid reductase 5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suberin-associated fatty alcohols in Arabidopsis: distributions in roots and contributions to seed coat barrier properties. Vishwanath SJ, et al. Plant Physiol, 2013 Nov. PMID 24019425, Free PMC Article
    2. Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition. Domergue F, et al. Plant Physiol, 2010 Aug. PMID 20571114, Free PMC Article
    3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data indicate that down-regulation of Arabidopsis FATTY ACYL REDUCTASE1 (FAR1), FAR4, and FAR5, which collectively produce the fatty alcohols found in suberin, reduced their levels by 70% to 80%.
      Title: Suberin-associated fatty alcohols in Arabidopsis: distributions in roots and contributions to seed coat barrier properties.
    2. FAR1, FAR4, and FAR5 generate the fatty alcohols found in root, seed coat, and wound-induced leaf tissue.
      Title: Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    NM_001339152.1
    NM_114322.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables long-chain-fatty-acyl-CoA reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to salt stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to wounding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within suberin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    fatty acid reductase 4
    NP_001319682.1
    • fatty acid reductase 4 (FAR4); CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), Male sterility, NAD-binding (InterPro:IPR013120); BEST Arabidopsis thaliana protein match is: fatty acid reductase 1 (TAIR:AT5G22500.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_190040.3
    • fatty acid reductase 4 (FAR4); CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), Male sterility (InterPro:IPR004262), Male sterility, NAD-binding (InterPro:IPR013120); BEST Arabidopsis thaliana protein match is: fatty acid reductase 1 (TAIR:AT5G22500.1); Has 1944 Blast hits to 1910 proteins in 300 species: Archae - 2; Bacteria - 305; Metazoa - 993; Fungi - 183; Plants - 285; Viruses - 0; Other Eukaryotes - 176 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      16123426..16128030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001339153.1 → NP_001327210.1  fatty acid reductase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VJU2, A0A1I9LRL6

    2. NM_114322.5 → NP_190040.3  fatty acid reductase 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_190040.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q2V3Q9, Q9LXN3
      UniProtKB/TrEMBL
      A0A5S9XHR2
      Conserved Domains (3) summary
      cd05236
      Location:12 → 362
      FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
      PLN02996
      Location:1 → 492
      PLN02996; fatty acyl-CoA reductase
      pfam03015
      Location:393 → 492
      Sterile; Male sterility protein

    3. NM_001339152.1 → NP_001319682.1  fatty acid reductase 4 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VJU2, A0A1I9LRL6
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9LXN3.1

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