U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    Gstm7 glutathione S-transferase, mu 7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81869, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Gstm7provided by RGD
    Official Full Name
    glutathione S-transferase, mu 7provided by RGD
    Primary source
    RGD:621287
    See related
    EnsemblRapid:ENSRNOG00000018937 AllianceGenome:RGD:621287
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gstm3
    Summary
    Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process. Predicted to be located in cytosol; intercellular bridge; and sarcoplasmic reticulum. Orthologous to human GSTM2 (glutathione S-transferase mu 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 416.8), Liver (RPKM 282.6) and 9 other tissues See more
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Gstm7 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (198254872..198260365, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (195566701..195572149, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (210720719..210726179, complement)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase, mu 5 Neighboring gene glutathione S-transferase, mu 5-like Neighboring gene uncharacterized LOC120100916 Neighboring gene glutathione S-transferase, mu 6 Neighboring gene glutathione S-transferase mu 3 like 1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Brain and testis selective expression of the glutathione S-transferase Yb3 subunit is governed by tandem direct repeat octamer motifs in the 5'-flanking region of its gene. Abramovitz M, et al. Brain Res Mol Brain Res, 1995 Jan. PMID 7707876
    2. Selective expression of a unique glutathione S-transferase Yb3 gene in rat brain. Abramovitz M, et al. J Biol Chem, 1987 Jun 5. PMID 3584141
    3. Glutathione S-transferase: genetics and role in toxicology. Strange RC, et al. Toxicol Lett, 2000 Mar 15. PMID 10720752
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

    Go to the top of the page

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables fatty acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione peroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glutathione transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glutathione transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables signaling receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification of nitrogen compound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to caffeine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glutathione metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutathione metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hepoxilin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in linoleic acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ryanodine-sensitive calcium-release channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nitrobenzene metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ryanodine-sensitive calcium-release channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xenobiotic catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in sarcoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    glutathione S-transferase Mu 7
    Names
    GST Yb3
    GST class-mu 3
    chain 4
    glutathione S-transferase Yb-3
    glutathione S-transferase, mu type 3 (Yb3)
    NP_112416.1
    XP_063138704.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031154.2 → NP_112416.1  glutathione S-transferase Mu 7

      See identical proteins and their annotated locations for NP_112416.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/Swiss-Prot
      P08009
      UniProtKB/TrEMBL
      A0A0G2K4U2, A6HUW1
      Related
      ENSRNOP00000025689.2, ENSRNOT00000025689.6
      Conserved Domains (3) summary
      cd03209
      Location:92 → 212
      GST_C_Mu; C-terminal, alpha helical domain of Class Mu Glutathione S-transferases
      COG0625
      Location:3 → 189
      GstA; Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]
      cd03075
      Location:3 → 84
      GST_N_Mu; GST_N family, Class Mu subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      198254872..198260365 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063282634.1 → XP_063138704.1  glutathione S-transferase Mu 7 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08009.2 GenPept UniProtKB/Swiss-Prot:P08009

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous