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    HESO1 Nucleotidyltransferase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818559, updated on 18-Sep-2024

    Summary

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    Official Symbol
    HESO1
    Official Full Name
    Nucleotidyltransferase family protein
    Primary source
    TAIR:AT2G39740
    Locus tag
    AT2G39740
    See related
    Araport:AT2G39740
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    HEN1 suppressor 1; T5I7.4; T5I7_4
    Summary
    Encodes HESO1 (HEN1 suppressor 1), a terminal nucleotidyl transferase that uridylates miRNAs and siRNAs at 3' end. HESO1-mediated 3' uridylation destabilizes small RNAs in hen1.
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    Genomic context

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    See HESO1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (16575752..16579120)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RING-H2 finger C2A Neighboring gene LYR family of Fe/S cluster biogenesis protein Neighboring gene rubisco activase Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene BTB/POZ/MATH-domains containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. HEN1 SUPPRESSOR1 stabilizes polymerase IV RNAs via uridylation in Arabidopsis. Ren Y, et al. Plant Physiol, 2023 Aug 31. PMID 37217838
    2. The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation. Zhao Y, et al. Curr Biol, 2012 Apr 24. PMID 22464194, Free PMC Article
    3. Uridylation of miRNAs by hen1 suppressor1 in Arabidopsis. Ren G, et al. Curr Biol, 2012 Apr 24. PMID 22464191, Free PMC Article
    4. Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis. Tu B, et al. PLoS Genet, 2015 Apr. PMID 25928405, Free PMC Article
    5. Synergistic and independent actions of multiple terminal nucleotidyl transferases in the 3' tailing of small RNAs in Arabidopsis. Wang X, et al. PLoS Genet, 2015 Apr. PMID 25928341, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. HEN1 SUPPRESSOR1 stabilizes polymerase IV RNAs via uridylation in Arabidopsis.
      Title: HEN1 SUPPRESSOR1 stabilizes polymerase IV RNAs via uridylation in Arabidopsis.
    2. URT1 and HESO1 prefer substrates with different 3' end nucleotides in vitro and act cooperatively to tail different forms of the same miRNAs in vivo. Moreover, both HESO1 and URT1 exhibit nucleotidyl transferase activity on AGO1-bound miRNAs
      Title: Distinct and cooperative activities of HESO1 and URT1 nucleotidyl transferases in microRNA turnover in Arabidopsis.
    3. our data not only reveal a synergistic action of HESO1 and URT1 in the 3' uridylation of miRNAs, but also independent activities of multiple terminal nucleotidyl transferases in the 3' tailing of small RNAs
      Title: Synergistic and independent actions of multiple terminal nucleotidyl transferases in the 3' tailing of small RNAs in Arabidopsis.
    4. HESO1 encodes a terminal nucleotidyl transferase that prefers to add untemplated uridine to the 3' end of RNA, which is completely abolished by 2'-O-methylation.[HESO1]
      Title: Uridylation of miRNAs by hen1 suppressor1 in Arabidopsis.
    5. HESO1 gene is responsible for small RNA uridylation and exhibits terminal nucleotidyl transferase activity, prefers uridine as the substrate nucleotide, and is completely inhibited by 2'-O-methylation.[HESO1]
      Title: The Arabidopsis nucleotidyl transferase HESO1 uridylates unmethylated small RNAs to trigger their degradation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001336793.1
    NM_001336794.1
    NM_129532.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA uridylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleotidyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA 3' uridylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within RNA 3' uridylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in miRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Nucleotidyltransferase family protein
    NP_001318386.1
    • Nucleotidyltransferase family protein; BEST Arabidopsis thaliana protein match is: Nucleotidyltransferase family protein (TAIR:AT3G45750.1); Has 1708 Blast hits to 1608 proteins in 227 species: Archae - 0; Bacteria - 13; Metazoa - 799; Fungi - 328; Plants - 255; Viruses - 0; Other Eukaryotes - 313 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16575752..16579120
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336793.1 → NP_001318386.1  Nucleotidyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22284, Q0WSQ3, Q5XET5
      UniProtKB/TrEMBL
      A0A178VNX4, A0A7G2EGU0
      Conserved Domains (1) summary
      COG5260
      Location:11 → 436
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    2. NM_001336794.1 → NP_001324414.1  Nucleotidyltransferase family protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22284, Q0WSQ3, Q5XET5
      UniProtKB/TrEMBL
      A0A178VNX4, A0A7G2EGU0
      Conserved Domains (1) summary
      COG5260
      Location:11 → 436
      TRF4; DNA polymerase sigma [Replication, recombination and repair]

    3. NM_129532.4 → NP_181504.2  Nucleotidyltransferase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181504.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O22284, Q0WSQ3, Q5XET5
      UniProtKB/TrEMBL
      A0A178VNX4, A0A7G2EGU0
      Conserved Domains (1) summary
      COG5260
      Location:11 → 436
      TRF4; DNA polymerase sigma [Replication, recombination and repair]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5XET5.1

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