Jup junction plakoglobin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Jupprovided by RGD
Official Full Name: junction plakoglobinprovided by RGD
Primary source: RGD:620412
See related: EnsemblRapid:ENSRNOG00000015380 AllianceGenome:RGD:620412
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables protein tyrosine kinase binding activity. Predicted to be involved in several processes, including cellular response to indole-3-methanol; regulation of DNA-templated transcription; and regulation of heart contraction. Predicted to act upstream of or within cell adhesion; desmosome assembly; and skin development. Located in several cellular components, including apicolateral plasma membrane; fascia adherens; and lateral plasma membrane. Human ortholog(s) of this gene implicated in cardiomyopathy (multiple); palmoplantar keratosis (multiple); renal cell carcinoma; and reproductive organ cancer (multiple). Orthologous to human JUP (junction plakoglobin). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 426.5), Heart (RPKM 313.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (85800812..85827881, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85300438..85327378, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88280517..88307451, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gamma-Catenin regulates expression of HDAC4, but not HDAC1 and HDAC2 in Rat-K-Ras cells.
Title: Identification of HDAC4 as a target of γ-catenin that regulates the oncogenic K-Ras-mediated malignant phenotype of Rat2 cells.
Results provide marker proteins Gap-43 and newly identified candidate neuronal growth-associated proteins MAP1B, CRMP5, crmp5 and catenins.
Title: Identification of functional marker proteins in the mammalian growth cone.
plakophilin-2 is indeed of obvious importance for myocardial architecture and cell-cell coupling of rat cardiomyocytes growing in culture.
Title: The area composita of adhering junctions connecting heart muscle cells of vertebrates. V. The importance of plakophilin-2 demonstrated by small interference RNA-mediated knockdown in cultured rat cardiomyocytes.
downregulated in liver epithelial cells after TCCD exposure
Title: TCDD-dependent downregulation of gamma-catenin in rat liver epithelial cells (WB-F344).

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Jup (e-PCR), detects polymorphism
- UniSTS:143648

RH128545 (e-PCR)
- UniSTS:211853

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables alpha-catenin binding	IBA Inferred from Biological aspect of Ancestor more info
enables alpha-catenin binding	IEA Inferred from Electronic Annotation more info
enables alpha-catenin binding	ISO Inferred from Sequence Orthology more info
enables cadherin binding	IBA Inferred from Biological aspect of Ancestor more info
enables cadherin binding	IEA Inferred from Electronic Annotation more info
enables cadherin binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables cytoskeletal protein-membrane anchor activity	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein-membrane anchor activity	ISO Inferred from Sequence Orthology more info
enables nuclear receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein phosphatase binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription coactivator activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication	IEA Inferred from Electronic Annotation more info
involved_in bundle of His cell-Purkinje myocyte adhesion involved in cell communication	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to indole-3-methanol	IEA Inferred from Electronic Annotation more info
involved_in cellular response to indole-3-methanol	ISO Inferred from Sequence Orthology more info
involved_in desmosome assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within desmosome assembly	ISO Inferred from Sequence Orthology more info
involved_in desmosome assembly	ISO Inferred from Sequence Orthology more info
involved_in detection of mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in detection of mechanical stimulus	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of blood vessel endothelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood vessel endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell-matrix adhesion	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate by cardiac conduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of heart rate by cardiac conduction	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell action potential	IEA Inferred from Electronic Annotation more info
involved_in regulation of ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in skin development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Z disc	IEA Inferred from Electronic Annotation more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in adherens junction	IEA Inferred from Electronic Annotation more info
located_in adherens junction	ISO Inferred from Sequence Orthology more info
located_in apicolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of catenin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of catenin complex	IEA Inferred from Electronic Annotation more info
part_of catenin complex	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IDA Inferred from Direct Assay more info	PubMed
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cornified envelope	IEA Inferred from Electronic Annotation more info
is_active_in cornified envelope	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in desmosome	IDA Inferred from Direct Assay more info	PubMed
located_in desmosome	IEA Inferred from Electronic Annotation more info
located_in desmosome	ISO Inferred from Sequence Orthology more info
located_in fascia adherens	IDA Inferred from Direct Assay more info	PubMed
part_of gamma-catenin-TCF7L2 complex	IEA Inferred from Electronic Annotation more info
part_of gamma-catenin-TCF7L2 complex	ISO Inferred from Sequence Orthology more info
located_in intercalated disc	IEA Inferred from Electronic Annotation more info
located_in intercalated disc	ISO Inferred from Sequence Orthology more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info
located_in intermediate filament	ISO Inferred from Sequence Orthology more info
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
part_of protein-DNA complex	IEA Inferred from Electronic Annotation more info
part_of protein-DNA complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: junction plakoglobin

Names: gamma-catenin (plakoglobin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031047.2 → NP_112309.2 junction plakoglobin

See identical proteins and their annotated locations for NP_112309.2

Status: PROVISIONAL

Source sequence(s)

BC065580

UniProtKB/Swiss-Prot

Q6P0K8

UniProtKB/TrEMBL

A6HJ29, P70565

Related

ENSRNOP00000043950.2, ENSRNOT00000040845.4

Conserved Domains (4) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

PLN03200
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

pfam00514
Location:221 → 253

Arm; Armadillo/beta-catenin-like repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

85800812..85827881 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247430.5 → XP_006247492.1 junction plakoglobin isoform X1

See identical proteins and their annotated locations for XP_006247492.1

UniProtKB/Swiss-Prot

Q6P0K8

UniProtKB/TrEMBL

A6HJ29, P70565

Conserved Domains (4) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

PLN03200
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

pfam00514
Location:221 → 253

Arm; Armadillo/beta-catenin-like repeat
XM_006247429.4 → XP_006247491.1 junction plakoglobin isoform X1

See identical proteins and their annotated locations for XP_006247491.1

UniProtKB/Swiss-Prot

Q6P0K8

UniProtKB/TrEMBL

A6HJ29, P70565

Conserved Domains (4) summary

smart00185
Location:341 → 381

ARM; Armadillo/beta-catenin-like repeats

PLN03200
Location:328 → 658

PLN03200; cellulose synthase-interactive protein; Provisional

sd00043
Location:393 → 418

ARM; armadillo repeat [structural motif]

pfam00514
Location:221 → 253

Arm; Armadillo/beta-catenin-like repeat
XM_063269944.1 → XP_063126014.1 junction plakoglobin isoform X1

UniProtKB/Swiss-Prot

Q6P0K8

UniProtKB/TrEMBL

A6HJ29
XM_063269946.1 → XP_063126016.1 junction plakoglobin isoform X1

UniProtKB/Swiss-Prot

Q6P0K8

UniProtKB/TrEMBL

A6HJ29
XM_063269945.1 → XP_063126015.1 junction plakoglobin isoform X1

UniProtKB/Swiss-Prot

Q6P0K8

UniProtKB/TrEMBL

A6HJ29