Bdkrb1 bradykinin receptor B1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Bdkrb1provided by RGD
Official Full Name: bradykinin receptor B1provided by RGD
Primary source: RGD:620401
See related: EnsemblRapid:ENSRNOG00000004488 AllianceGenome:RGD:620401
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: BKR; Bdkrb; b1bkr
Summary: Enables bradykinin receptor activity and peptide binding activity. Involved in several processes, including negative regulation of protein phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; and response to lipopolysaccharide. Predicted to be active in plasma membrane. Used to study several diseases, including diabetic angiopathy; hypertension; neuropathy (multiple); overactive bladder syndrome; and pleurisy. Biomarker of diabetic retinopathy; hypertension; and myocardial infarction. Human ortholog(s) of this gene implicated in end stage renal disease; hypertension; and pulmonary fibrosis. Orthologous to human BDKRB1 (bradykinin receptor B1). [provided by Alliance of Genome Resources, Oct 2024]
Expression: Biased expression in Uterus (RPKM 5.6), Adrenal (RPKM 1.6) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q32

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (130275631..130284968)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (124510827..124514475)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (129437423..129441553)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome.
Title: The Expression of RAAS Key Receptors, Agtr2 and Bdkrb1, Is Downregulated at an Early Stage in a Rat Model of Wolfram Syndrome.
Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors.
Title: Myocardial angiogenesis induced by exercise training involves a regulatory mechanism mediated by kinin receptors.
Findings show that B1R negatively regulates collagen synthesis in cardiac myofibroblasts involving differents signaling pathways.
Title: TGF-β1 induced up-regulation of B1 kinin receptor promotes antifibrotic activity in rat cardiac myofibroblasts.
Our results support the detrimental role of B1 receptors on endothelial and glial cells in acute and advanced phases of diabetes retinopathy
Title: Expression, distribution and function of kinin B(1) receptor in the rat diabetic retina.
High bradykinin receptor B1 expression is associated with spinal cord ischemia-reperfusion injury.
Title: The expression of bradykinin and its receptors in spinal cord ischemia-reperfusion injury rat model.
The experimental periodontitis in rats can induce systemic inflammation and up-regulate B1 kinin receptors in the rat paw, modifying the inflammatory response at a site distant from oral infection.
Title: Experimental periodontitis in rats potentiates inflammation at a distant site: Role of B(1) kinin receptor.
Hearts of rats overexpressing the B1R exclusively in the endothelium have expanded LV cavities with reduced capacity to generate pressure and shortening, suggesting myocardial depression.
Title: Cardiac morphofunctional characteristics of transgenic rats with overexpression of the bradykinin B1 receptor in the endothelium.
upregulated B1R may contribute to early hemorrhagic transformation after cerebral ischemia/reperfusion in type 1 diabetic rats
Title: Early Increased Bradykinin 1 Receptor Contributes to Hemorrhagic Transformation After Ischemic Stroke in Type 1 Diabetic Rats.
Mas receptor antagonist abolished relaxation while bradykinin receptor antagonist only slightly reduced it, suggesting that bradykinin-induced vasorelaxation is regulated also by other mechanisms than the classical BR1/BR2 pathway.
Title: Bradykinin -induced vasodilatation: Role of age, ACE1-inhibitory peptide, mas- and bradykinin receptors.
data imply in a possible participation of B1R in the short term memory impairment observed in traumatic brain injury, neuroinflammation and neurodegeneration
Title: Kinin B1 receptor mediates memory impairment in the rat hippocampus.

Submit: New GeneRIF Correction See all GeneRIFs (50)

General gene information

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Markers

RH142435 (e-PCR)
- UniSTS:231682

UniSTS:495960 (e-PCR)
- UniSTS:495960

Bdkrb1 (e-PCR), detects polymorphism
- UniSTS:495960

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bradykinin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables bradykinin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables bradykinin receptor activity	ISO Inferred from Sequence Orthology more info
enables peptide binding	IPI Inferred from Physical Interaction more info	PubMed
enables peptide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cyclooxygenase pathway	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of blood pressure	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cell growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in positive regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of release of sequestered calcium ion into cytosol	IDA Inferred from Direct Assay more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to lipopolysaccharide	ISO Inferred from Sequence Orthology more info
involved_in response to mechanical stimulus	IEA Inferred from Electronic Annotation more info
involved_in smooth muscle relaxation of the bladder outlet	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: B1 bradykinin receptor

Names: B1R; BK-1 receptor; KB1; bradykinin B1 receptor; bradykinin receptor, beta 1; kinin B1 receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.