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    PF3D7_0206800 merozoite surface protein 2 [ Plasmodium falciparum 3D7 ]

    Gene ID: 812660, updated on 17-May-2024

    Summary

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    Gene symbol
    PF3D7_0206800
    Gene description
    merozoite surface protein 2
    Primary source
    PlasmoDB:PF3D7_0206800
    Locus tag
    PF3D7_0206800
    See related
    VEuPathDB:PF3D7_0206800
    Gene type
    protein coding
    RNA name
    merozoite surface protein 2
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_0206800 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    1
    Sequence:
    Chromosome: 2; NC_037280.1 (273689..274507, complement)

    Chromosome 2 - NC_037280.1Genomic Context describing neighboring genes Neighboring gene DNA-directed RNA polymerase III subunit RPC10, putative Neighboring gene adenylosuccinate lyase Neighboring gene merozoite surface protein 5 Neighboring gene merozoite surface protein 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037280.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic polymorphisms of Plasmodium falciparum isolates from Melka-Werer, North East Ethiopia based on the merozoite surface protein-2 (msp-2) gene as a molecular marker. Mohammed H, et al. Malar J, 2021 Feb 12. PMID 33579293, Free PMC Article
    2. Immunization with merozoite surface protein 2 fused to a Plasmodium-specific carrier protein elicits strain-specific and strain-transcending, opsonizing antibody. Eacret JS, et al. Sci Rep, 2019 Jun 21. PMID 31227760, Free PMC Article
    3. Interaction of merozoite surface protein 2 with lipid membranes. Lu C, et al. FEBS Lett, 2019 Feb. PMID 30588612
    4. Genetic polymorphism of Merozoite Surface Protein-2 (MSP-2) in Plasmodium falciparum isolates from Pawe District, North West Ethiopia. Mohammed H, et al. PLoS One, 2017. PMID 28542247, Free PMC Article
    5. Reduction of multiplicity of infections but no change in msp2 genetic diversity in Plasmodium falciparum isolates from Congolese children after introduction of artemisinin-combination therapy. Ibara-Okabande R, et al. Malar J, 2012 Dec 7. PMID 23217196, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Low genetic diversity of Plasmodium falciparum merozoite surface protein 1 and 2 and multiplicity of infections in western Ethiopia following effective malaria interventions.
      Title: Low genetic diversity of Plasmodium falciparum merozoite surface protein 1 and 2 and multiplicity of infections in western Ethiopia following effective malaria interventions.
    2. Plasmodium falciparum msp1 and msp2 genetic diversity in parasites isolated from symptomatic and asymptomatic malaria subjects in the South of Benin.
      Title: Plasmodium falciparum msp1 and msp2 genetic diversity in parasites isolated from symptomatic and asymptomatic malaria subjects in the South of Benin.
    3. Genetic polymorphisms of Plasmodium falciparum isolates from Melka-Werer, North East Ethiopia based on the merozoite surface protein-2 (msp-2) gene as a molecular marker.
      Title: Genetic polymorphisms of Plasmodium falciparum isolates from Melka-Werer, North East Ethiopia based on the merozoite surface protein-2 (msp-2) gene as a molecular marker.
    4. Immunization with merozoite surface protein 2 fused to a Plasmodium-specific carrier protein elicits strain-specific and strain-transcending, opsonizing antibody.
      Title: Immunization with merozoite surface protein 2 fused to a Plasmodium-specific carrier protein elicits strain-specific and strain-transcending, opsonizing antibody.
    5. Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes and multiplicity of Plasmodium falciparum infection across various endemic areas in Senegal.
      Title: Genetic polymorphism of Merozoite Surface Protein 1 (msp1) and 2 (msp2) genes and multiplicity of Plasmodium falciparum infection across various endemic areas in Senegal.
    6. Interaction of merozoite surface protein 2 with lipid membranes.
      Title: Interaction of merozoite surface protein 2 with lipid membranes.
    7. Genetic polymorphism of Merozoite Surface Protein-2 (MSP-2) in Plasmodium falciparum isolates from Pawe District, North West Ethiopia
      Title: Genetic polymorphism of Merozoite Surface Protein-2 (MSP-2) in Plasmodium falciparum isolates from Pawe District, North West Ethiopia.
    8. msp2 genetic profiles iof solates collected from successive malaria episodes in ten children who had four or more clinical episodes during follow up
      Title: Reduction of multiplicity of infections but no change in msp2 genetic diversity in Plasmodium falciparum isolates from Congolese children after introduction of artemisinin-combination therapy.
    9. MSP2 Antigenic differences characterized via epitope mapping; results show that there are significant conformational differences between the two forms of MSP2
      Title: Antigenic characterization of an intrinsically unstructured protein, Plasmodium falciparum merozoite surface protein 2.
    10. Allele typing of the msp2 gene detected 55% and 45% of 3D7 and FC27 allelic families in Plasmodium falciparum field isolates from Congolese children with asymptomatic infections.
      Title: Genetic polymorphism of merozoite surface protein 2 and prevalence of K76T pfcrt mutation in Plasmodium falciparum field isolates from Congolese children with asymptomatic infections.
    Submit: New GeneRIF Correction See all GeneRIFs (22)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    merozoite surface protein 2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_037280.1 Reference assembly

      Range
      273689..274507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001349542.1 → XP_001349578.1  merozoite surface protein 2 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001349578.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      A0A143ZX41, P50498, Q9TY97
      UniProtKB/TrEMBL
      Q25862, W7KN63
      Conserved Domains (1) summary
      pfam00985
      Location:102 → 272
      MSA_2; Merozoite Surface Antigen 2 (MSA-2) family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50498.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials