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    ZDHHC14 zinc finger DHHC-type palmitoyltransferase 14 [ Homo sapiens (human) ]

    Gene ID: 79683, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZDHHC14provided by HGNC
    Official Full Name
    zinc finger DHHC-type palmitoyltransferase 14provided by HGNC
    Primary source
    HGNC:HGNC:20341
    See related
    Ensembl:ENSG00000175048 MIM:619295; AllianceGenome:HGNC:20341
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NEW1CP
    Summary
    Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 2.5), endometrium (RPKM 2.3) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZDHHC14 in Genome Data Viewer
    Location:
    6q25.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (157381190..157678157)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (158623184..158923532)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (157802222..158099189)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chromosome 18 open reading frame 21 pseudogene Neighboring gene uncharacterized LOC124901446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157800546-157801158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17723 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:157801770-157802381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25331 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr6:157818864-157819364 and GRCh37_chr6:157819365-157819865 Neighboring gene MPRA-validated peak6255 silencer Neighboring gene MPRA-validated peak6257 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:157867979-157868480 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:157868882-157869106 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157876133-157877024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157885378-157885878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157885879-157886379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157887214-157888001 Neighboring gene MPRA-validated peak6259 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157938365-157938888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157938889-157939410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157951781-157952686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157952687-157953591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157954158-157954658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157954659-157955159 Neighboring gene MPRA-validated peak6260 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157973253-157974075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157977751-157978536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157982847-157983820 Neighboring gene microRNA 3692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157993864-157994596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158014227-158014728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158014729-158015228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158037061-158037562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158037563-158038062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158066653-158067153 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:158069048-158070247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158090399-158091006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158091007-158091612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158109923-158110424 Neighboring gene uncharacterized LOC107986663 Neighboring gene NANOG hESC enhancer GRCh37_chr6:158127150-158127715 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:158131630-158132829 Neighboring gene uncharacterized LOC124901555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158134197-158134698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158134699-158135198 Neighboring gene NANOG hESC enhancer GRCh37_chr6:158152966-158153487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158153745-158154270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:158162257-158162797 Neighboring gene Sharpr-MPRA regulatory region 4686 Neighboring gene Sharpr-MPRA regulatory region 7014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:158183852-158185051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25339 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:158251124-158251862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25340 Neighboring gene Sharpr-MPRA regulatory region 12251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17728 Neighboring gene sorting nexin 9 Neighboring gene SNX9 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer. Oo HZ, et al. Oncol Rep, 2014 Jul. PMID 24807047
    2. Identification of ZDHHC14 as a novel human tumour suppressor gene. Yeste-Velasco M, et al. J Pathol, 2014 Apr. PMID 24407904
    3. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. Sanders SS, et al. Elife, 2020 Nov 13. PMID 33185190, Free PMC Article
    4. S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary. Adachi N, et al. J Biol Chem, 2016 Sep 16. PMID 27481942, Free PMC Article
    5. Regulation of RAS palmitoyltransferases by accessory proteins and palmitoylation. Yang A, et al. Nat Struct Mol Biol, 2024 Mar. PMID 38182928

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
      Title: The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
    2. Results indicate that ZDHHC14 is involved in tumor progression in patients with scirrhous type gastric cancer.
      Title: Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer.
    3. Identify ZDHHC14 as a novel tumour suppressor gene that is commonly down-regulated in testicular germ cell tumours and prostate cancer.
      Title: Identification of ZDHHC14 as a novel human tumour suppressor gene.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ20984

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables palmitoyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-cysteine S-palmitoyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-cysteine S-palmitoyltransferase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peptidyl-L-cysteine S-palmitoylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein palmitoylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein targeting to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi cisterna membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    palmitoyltransferase ZDHHC14
    Names
    DHHC domain-containing cysteine-rich protein 14
    DHHC-14
    NEW1 domain-containing protein
    probable palmitoyltransferase ZDHHC14
    zinc finger DHHC domain-containing protein 14
    zinc finger DHHC-type containing 14
    zinc finger, DHHC domain containing 14
    NP_078906.2
    NP_714968.1
    XP_016866797.1
    XP_016866798.1
    XP_016866799.1
    XP_047275322.1
    XP_047275324.1
    XP_054212412.1
    XP_054212413.1
    XP_054212414.1
    XP_054212415.1
    XP_054212416.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024630.3 → NP_078906.2  palmitoyltransferase ZDHHC14 isoform 1

      See identical proteins and their annotated locations for NP_078906.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AF542388, AL117344, AL133510
      Consensus CDS
      CCDS5252.1
      UniProtKB/Swiss-Prot
      A6NDB7, Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q8IZN3, Q9H7F1
      UniProtKB/TrEMBL
      A4FVA9
      Related
      ENSP00000352821.5, ENST00000359775.10
      Conserved Domains (2) summary
      PHA03247
      Location:314 → 485
      PHA03247; large tegument protein UL36; Provisional
      pfam01529
      Location:164 → 287
      DHHC; DHHC palmitoyltransferase

    2. NM_153746.2 → NP_714968.1  palmitoyltransferase ZDHHC14 isoform 2

      See identical proteins and their annotated locations for NP_714968.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AF542389, AL117344
      Consensus CDS
      CCDS47510.1
      UniProtKB/TrEMBL
      A4FVA9
      Related
      ENSP00000410713.2, ENST00000414563.6
      Conserved Domains (2) summary
      PHA03247
      Location:314 → 470
      PHA03247; large tegument protein UL36; Provisional
      pfam01529
      Location:164 → 287
      DHHC; DHHC palmitoyltransferase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      157381190..157678157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419366.1 → XP_047275322.1  palmitoyltransferase ZDHHC14 isoform X3

    2. XM_017011308.2 → XP_016866797.1  palmitoyltransferase ZDHHC14 isoform X1

    3. XM_017011309.2 → XP_016866798.1  palmitoyltransferase ZDHHC14 isoform X2

    4. XM_017011310.2 → XP_016866799.1  palmitoyltransferase ZDHHC14 isoform X4

    5. XM_047419368.1 → XP_047275324.1  palmitoyltransferase ZDHHC14 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      158623184..158923532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356439.1 → XP_054212414.1  palmitoyltransferase ZDHHC14 isoform X3

    2. XM_054356437.1 → XP_054212412.1  palmitoyltransferase ZDHHC14 isoform X1

    3. XM_054356438.1 → XP_054212413.1  palmitoyltransferase ZDHHC14 isoform X2

    4. XM_054356440.1 → XP_054212415.1  palmitoyltransferase ZDHHC14 isoform X4

    5. XM_054356441.1 → XP_054212416.1  palmitoyltransferase ZDHHC14 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IZN3.1 GenPept UniProtKB/Swiss-Prot:Q8IZN3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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