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    OR6J1 olfactory receptor family 6 subfamily J member 1 [ Homo sapiens (human) ]

    Gene ID: 79549, updated on 2-Nov-2024

    Summary

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    Official Symbol
    OR6J1provided by HGNC
    Official Full Name
    olfactory receptor family 6 subfamily J member 1provided by HGNC
    Primary source
    HGNC:HGNC:14707
    See related
    Ensembl:ENSG00000255804 AllianceGenome:HGNC:14707
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OR6J2; OR6J1P
    Summary
    Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jan 2017]
    Annotation information
    Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
    Orthologs
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    Genomic context

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    See OR6J1 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (22630929..22644352, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (16828656..16842613, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23099834..23113561, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr14:23039191-23039913 Neighboring gene defender against cell death 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:23049159-23049321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23051199-23051700 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23057127-23057768 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23057769-23058410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5587 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8136 Neighboring gene abhydrolase domain containing 4, N-acyl phospholipase B Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23105272-23105983 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8137 Neighboring gene ribosomal protein L26 pseudogene 2 Neighboring gene olfactory receptor family 6 subfamily E member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables olfactory receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detection of chemical stimulus involved in sensory perception of smell IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    olfactory receptor 6J1
    Names
    Olfactory receptor 6J1
    olfactory receptor 6J2
    olfactory receptor, family 6, subfamily J, member 1 pseudogene
    olfactory receptor, family 6, subfamily J, member 2
    seven transmembrane helix receptor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001348233.2 → NP_001335162.1  olfactory receptor 6J1

      Status: VALIDATED

      Source sequence(s)
      AC243945
      Consensus CDS
      CCDS86371.1
      UniProtKB/Swiss-Prot
      Q8NGC5
      UniProtKB/TrEMBL
      A0A126GWP5
      Related
      ENSP00000437629.1, ENST00000540461.2
      Conserved Domains (1) summary
      cd15912
      Location:44 → 293
      7tmA_OR6C-like; olfactory receptor subfamily 6C and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      22630929..22644352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      16828656..16842613 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NG_002274.13: Suppressed sequence

      Description
      NG_002274.13: This RefSeq was removed because it is now thought that this gene does encode a protein.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8NGC5.2 GenPept UniProtKB/Swiss-Prot:Q8NGC5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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